Results 51 to 60 of about 462,772 (320)

Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis

Advancement of science
Ferroptosis is a necrotic form of iron‐dependent regulatory cell death. Estrogen withdrawal can interfere with iron metabolism, which is responsible for the pathogenesis of postmenopausal osteoporosis (PMOP).
Zeng-Xin Jiang, Guobin Qi, Xue-Cheng He, Yifan Yu, Yuting Cao, Chang-Qing Zhang, Weiguo Zou, Heng-Feng Yuan   +7 more
semanticscholar   +1 more source

Treatment of postmenopausal osteoporosis [PDF]

BMJ, 2005
Has improved owing to the availability of many drugs that prevent fractures Osteoporosis is characterised by bone fragility due to low bone mass and modifications of the internal bone structure, with alterations of its microarchitecture. Of various fragility fractures that represent the major complication of the disease, vertebral and hip fractures ...
openaire   +4 more sources

The Impact of Vertebral Fractures on Quality of Life in Postmenopausal Osteoporosis

, 2011
Aim: The aim of this study was to investigate the impact of vertebral fractures on quality of life in postmenopausal osteoporosis. Material and Methods: 158 postmenopausal women were included in this study.
Hakan Nur, N. Füsun Toraman
core   +1 more source

Assessment and Treatment of Postmenopausal Osteoporosis: An Appraisal of International Guidelines

Journal of Clinical Rheumatology and Immunology, 2022
Recently, several updates in the assessment and treatment of postmenopausal osteoporosis guidelines were published. This review discusses international guidelines, including the algorithm for management of patients at risk of osteoporotic fracture from ...
Sumapa Chaiamnuay
doaj   +1 more source

Bone targeting antioxidative nano-iron oxide for treating postmenopausal osteoporosis

Bioactive Materials, 2021
Osteoporosis is the most common degenerative orthopedic disease in the elderly. Recently, the therapeutic methods for osteoporosis have shifted towards the regulation of local immunity in bone tissues, which could provide a suitable environment for the ...
Li-Ming Zheng, Zai-Kai Zhuang, Yi-Xuan Li, T. Shi, Kai Fu, Wen-Jin Yan, Lei Zhang, Peng Wang, Lan Li, Qing Jiang   +9 more
semanticscholar   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

When, where and how osteoporosis-associated fractures occur: An analysis from the global longitudinal study of osteoporosis in women (GLOW) [PDF]

, 2013
Objective: To examine when, where and how fractures occur in postmenopausal women. Methods: We analyzed data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), including women aged ≥55 years from the United States of America, Canada ...
Anderson, Frederick A, Adachi, JD, Stephen H Gehlbach, Universitat Autònoma de Barcelona. Departament de Medicina, Adachi, Jonathan D., Chapurlat, Roland D., Frederick H Hooven, Díez Pérez, Adolfo, Nelson B Watts, Adachi, Jonathan D, Nieves, JW, Netelenbos, J.C., Lyn March, Boonen, S, Saag, Kenneth G., Compston, Juliet E., Roux, Christian, Pfeilschifter, Johannes, Rossini, Maurizio, Boonen, Steven, Pfeilschifter J, Ethel S Siris, Boonen S, Siris, E.S., Anderson, F.A., LaCroix, Andrea Z., Siris, Ethel S., Adami, Silvano, Adami, S., Watts NB, Jeri W Nieves, Lacroix, A.Z., Watts, NB, Gehlbach SH, Roux, C., Maurizio Rossini, Compston, JE, Gehlbach, S.H., Costa AG, Pfeilschifter, J., Rossini, M., Christian Roux, Boonen, S., Greenspan SL, Susan L Greenspan, Watts, N.B., Compston JE, Costa, Aline G. [UNIFESP], Greenspan, Susan L., Gehlbach, SH, March, L., Adami, S, Saag KG, Roux, C, Adachi JD, Saag, KG, Anderson, Frederick A., Greenspan, SL, Compston, Juliet E, Anderson FA Jr, Saag, Kenneth G, Hooven, Frederick H., Netelenbos JC, Cooper, C., March, Lyn, Díez Pérez A, Nieves, Jeri W., Cooper, C, Adachi, J.D., March, L, Nieves, Jeri W, Hooven, F.H., Andrea Z LaCroix, Silverman S, LaCroix, Andrea Z, Kenneth G Saag, Watts, Nelson B, Adolfo Díez-Pérez, Chapurlat, RD, Saag, K.G., Aline G Costa, Silverman, Stuart, Rossini, M, Juliet E Compston, Compston, J.E., Diez-Perez, A., Diez-Perez, Adolfo, Wyman, Allison, Stuart Silverman, Chapurlat, Roland D, Anderson Jr, Frederick A., Nieves JW, Silverman, S., Netelenbos, J. Coen, Jonathan D Adachi, Roux C, Cyrus Cooper, Gehlbach, Stephen H., Siris, Ethel S, Netelenbos, J Coen, Roland D Chapurlat, Siris, ES, Frederick A Anderson, March L, Pfeilschifter, J, Costa, A.G., Hooven, FH, Allison Wyman, LaCroix, AZ, Gehlbach, Stephen H, Lacroix AZ, Chapurlat, Roland, Wyman, A., Chapurlat, R.D., Greenspan, Susan L, Díez-Pérez, A, Silvano Adami, Anderson, FA, Cooper, Cyrus, Costa, Aline G, Chapurlat RD, Wyman, A, J Coen Netelenbos, Hooven, Frederick H, Hooven FH, Siris ES, Steven Boonen, Wyman A, Silverman, S, Costa, Aline G., Greenspan, S.L., Watts, Nelson B., Johannes Pfeilschifter, Netelenbos, JC, Nieves, J.W., Costa, AG, Cooper C, Nieves Jeri W., Adami Silvano, Anderson Frederick A., Siris Ethel S., Cooper Cyrus, Adachi Jonathan D., Netelenbos J. Coen, Gehlbach Stephen H., Watts Nelson B., Díez-Pérez Adolfo, Silverman Stuart, Greenspan Susan L., Compston Juliet E., LaCroix Andrea Z., Saag Kenneth G., Rossini Maurizio, Wyman Allison, Boonen Steven, March Lyn, Hooven Frederick H., Pfeilschifter Johannes, Roux Christian, Chapurlat Roland D., Costa Aline G.   +160 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Similarities in Acquired Factors Related to Postmenopausal Osteoporosis and Sarcopenia

Journal of Osteoporosis, 2011
Postmenopausal population is at increased risk of musculoskeletal impairments. Sarcopenia and osteoporosis are associated with significant morbidity and social and health-care costs.
Joonas Sirola, Heikki Kröger
doaj   +1 more source

Osteoporosis knowledge and beliefs among postmenopausal women: A cross-sectional study from a teaching hospital in southern India

Journal of Family Medicine and Primary Care, 2019
Objectives: Osteoporosis continues to be underrecognized in many parts of India. This study was undertaken to assess the level of knowledge of osteoporosis among postmenopausal women referred for a dual-energy X-ray absorptiometry (DXA) scan in a ...
Manickavasagam Senthilraja, Kripa Elizabeth Cherian, Felix K Jebasingh, Nitin Kapoor, Thomas Vizhalil Paul, Hesarghatta Shyamasunder Asha   +5 more
doaj   +1 more source