Results 181 to 190 of about 266,825 (311)

Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies

ChemMedChem, EarlyView.
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean‐François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Targeted Gene Sequencing in a Male Adult Diagnosed With X-Linked Osteoporosis Due to a Novel p.(Arg398Profs*2) <i>PLS3</i> Variant. [PDF]

JCEM Case Rep
Ye S, Taylor-Miller T, Grill V, Ebeling PR, Nguyen HH.   +4 more
europepmc   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. [PDF]

, 1983
A. M. Parfitt, Catharina H. E. Mathews, A. R. Villanueva, Michael Kleerekoper, Boy Frame, D. Srinivasa Rao   +5 more
openalex   +1 more source

Impact of anti-osteoporotic treatments on hyperlipidemia risk in osteoporosis patients: evidence from a population-based retrospective cohort study. [PDF]

Eur J Med Res
Hsieh HH, Tien N, Lin CL, Wong WH, Lee WY, Chen CH, Tsai FJ, You BJ, Fang YJ, Lim YP.   +9 more
europepmc   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

Vitamin D Metabolism and the Response to 1,25-Dihydroxycholecalciferol in Osteoporosis

, 1977
Michael Davies, E.B. Mawer, P. H. Adams
openalex   +1 more source

Multi-omics Mendelian randomization integrating RNA-seq, eQTL and pQTL data revealed CPXM1 as a potential drug target for osteoporosis. [PDF]

Hereditas
Lian J, Zhang X, Shi S, Li X, Wang Z, Pang H, Wang T, Gao W, Liu X.   +8 more
europepmc   +1 more source

Assessing Severity in Anorexia Nervosa Using Alternative Criteria to the DSM‐5 in a Cross‐Sectional Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study compared overvaluation of weight and shape (OWS), drive for thinness (DT), and their combination (OWS‐DT) as alternative severity classifications for anorexia nervosa (AN) to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5) severity classification.
Esther Henriet, Joanna Norton, Maude Seneque, Laurent Maimoun, Philippe Courtet, Sébastien Guillaume   +5 more
wiley   +1 more source

Pain in the knee associated with osteoporosis of the patella.

, 1977
M Corbett, JEAN R. COLSTON, Alan Tucker
openalex   +1 more source