Results 51 to 60 of about 401,073 (266)
Journal of Clinical Endocrinology and Metabolism, 2019 OBJECTIVE The objective is to formulate clinical practice guidelines for the pharmacological management of osteoporosis in postmenopausal women. CONCLUSIONS Evidence from clinical trials and insights from clinical experience with pharmacologic ...
R. Eastell +6 more
semanticscholar +1 more source
Endocrine reviews, 2021 Osteoporosis is a global public health problem, with fractures contributing to significant morbidity and mortality. Although post-menopausal osteoporosis is most common, up to 30% of post-menopausal women, >50% of premenopausal women, and between 50-80 ...
P. Ebeling +5 more
semanticscholar +1 more source
BMC News and views, 1996 Hip fractures in men account for one third of all hip fractures and have a higher mortality than in women. The public health burden will increase as the increase in the numbers of elderly men in the community increases. In addition, the age-specific incidence of hip fractures may be increasing in some, but not all, countries. Vertebral fractures may be
openaire +5 more sources
Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis
New England Journal of Medicine, 2017 BACKGROUND Romosozumab is a monoclonal antibody that binds to and inhibits sclerostin, increases bone formation, and decreases bone resorption. METHODS We enrolled 4093 postmenopausal women with osteoporosis and a fragility fracture and randomly assigned
K. Saag +9 more
semanticscholar +1 more source
Opportunistic Screening of Osteoporosis Using Plain Film Chest X-ray [PDF]
arXiv, 2021 Osteoporosis is a common chronic metabolic bone disease that is often under-diagnosed and under-treated due to the limited access to bone mineral density (BMD) examinations, Dual-energy X-ray Absorptiometry (DXA). In this paper, we propose a method to predict BMD from Chest X-ray (CXR), one of the most common, accessible, and low-cost medical image ...
arxiv
Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics
International Journal of Molecular Sciences, 2021 Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone homeostasis, which is maintained by an intricate balance between bone formation and bone resorption, undergoes deregulation.
Abhishek Chandra, J. Rajawat
semanticscholar +1 more source
The role of the P2X7 receptor on bone loss in a mouse model of inflammation-mediated osteoporosis
Bone Reports, 2017 In inflammatory autoimmune diseases, bone loss is frequent. In most cases, secondary osteoporosis is caused by treatment with systemic glucocorticoid. However, the pathogenesis behind the bone loss is presumed multifactorial.
T.M. Kvist +5 more
doaj +1 more source
Cells, 2021 There are numerous studies that investigate the effects of static magnetic fields (SMFs) on osteoblasts and osteoclasts. However, although osteocytes are the most abundant cell type in bone tissue, there are few studies on the biological effects of ...
Jiancheng Yang +6 more
doaj +1 more source
Denosumab for prevention of fractures in postmenopausal women with osteoporosis.
New England Journal of Medicine, 2009 BACKGROUND Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor-kappaB ligand (RANKL) that blocks its binding to RANK, inhibiting the development and activity of osteoclasts, decreasing bone resorption, and ...
S. Cummings +15 more
semanticscholar +1 more source
Romosozumab Treatment in Postmenopausal Women with Osteoporosis.
New England Journal of Medicine, 2016 BACKGROUND Romosozumab, a monoclonal antibody that binds sclerostin, increases bone formation and decreases bone resorption. METHODS We enrolled 7180 postmenopausal women who had a T score of -2.5 to -3.5 at the total hip or femoral neck. Patients were
F. Cosman +16 more
semanticscholar +1 more source