Results 41 to 50 of about 21,209 (213)

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Circulating levels of osteoprotegerin and sRANKL and the effect of methotrexate in patients with rheumatoid arthritis

Indian Journal of Rheumatology, 2018
Background: Receptor activator of nuclear factor κβ ligand (RANKL) and osteoprotegerin (OPG) are pivotal molecules involved in osteoclast activation and resorption.
Aadhaar Dhooria, Narendhiran Pandurangan, Karthik Vinay Mahesh, Suchet Sachdev, Aman Sharma, Shefali Sharma, Nidhi Gupta, Varun Dhir   +7 more
doaj   +1 more source

Pangasius djambal gelatin increases osteoprotegerin, decreases RANK and RANKL after tooth extraction in vivo

Dental Journal, 2023
Background: Osteoprotegerin (OPG) plays a role in preventing osteoclast formation and osteoclastic bone resorption by inhibiting the receptor activator nuclear factor-β and its ligand (RANK–RANKL) interaction that causes bone resorption.
Fredy Mardiyantoro, Nenny Prasetyaningrum, Lukman H. Hidayat, Uswatun Khasanah, Virginia C. Roring, Ahida Muizun, Varellia A. W. Kardikadewi   +6 more
doaj   +1 more source

Higher Bone Mineral Density in Obesity Masks Impaired Bone Remodeling and Disproportionate Musculoskeletal Adaptation in Young Women. [PDF]

FASEB J
Women with obesity exhibited higher total and site‐specific BMD and greater lean mass than lean controls. However, reduced BMD‐to‐fat and lean‐to‐fat mass ratios, increased CTX1 and RANK‐L/OPG, and decreased P1NP and osteocalcin indicated impaired bone remodeling, suggesting that increased BMD masks altered bone turnover and compromised skeletal health.
Forte YS, Andrade-Santos C, Pantoja-Marinho C, González-Joaquim L, Penna-De-Carvalho A, Leal PRF, Lopes KG, Kraemer-Aguiar LG, Barja-Fidalgo C.   +8 more
europepmc   +2 more sources

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

Arthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source

Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study

Selcuk Dental Journal, 2019
Background:The aim of this study was to investigate levels of bone morphogenetic protein-2 (BMP-2), BMP-7, soluble receptor activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) in the peri-implant crevicular fluid (PICF) of  implants ...
Mehmet Sağlam, Doğan Dolanmaz, Emrah Koçak, Burcu Poyraz, Özgür İnan, Niyazi Dündar, Sema Hakkı   +6 more
doaj   +1 more source

Pathogenetic and diagnostic role of osteoprotegerin in the combined course of osteoarthritis and obesity

Journal of Education, Health and Sport, 2022
In recent years, it has been proven that the formation of OA can occur against the background of impaired bone metabolism. Bone remodeling is considered as a continuous complex process aimed at eliminating microdamages and updating the bone matrix. A
A. Litvynova, L. Pasiieshvili
doaj   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

Serum osteoprotegerin and renal osteodystrophy [PDF]

Nephrology Dialysis Transplantation, 2002
Numerous growth factors and cytokines are known to modulate bone turnover. An important, recently discovered complex involved in osteoclastogenesis is the osteoprotegerin/osteoprotegerin-ligand (OPG/OPGL) cytokine complex, which is produced by osteoblasts.
Coen, Giorgio, Ballanti, Paola, Balducci, Alessandro, Calabria, Santo, Fischer, Maria Stephanie, Jankovic, Ljiljana, Manni, Micaela, Morosetti, Massimo, Moscaritolo, Eleonora, Sardella, Daniela, Bonucci, Ermanno   +10 more
openaire   +3 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source