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Nature Reviews Disease Primers, 2022 Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in males. The key pathophysiological mechanism involves several possible genetic drivers of disease linked to bone formation, causing malignant progression and metastasis.
Hannah C. Beird +9 more
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Osteosarcoma and Metastasis [PDF]
Frontiers in Oncology, 2021 Osteosarcoma is the most common primary bone malignancy in adolescents. Its high propensity to metastasize is the leading cause for treatment failure and poor prognosis.
Gaohong Sheng +3 more
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Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Bone Research, 2023 Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival rate has only shown limited improvement, suggesting that existing ...
Hailong Tian +6 more
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Journal of Bone and Mineral Research, 2010 Abstract It has been difficult to identify the molecular features central to the pathogenesis of osteosarcoma owing to a lack of understanding of the cell or origin, the absence of identifiable precursor lesions, and its marked genetic complexity at the time of presentation.
Richard, Gorlick, Chand, Khanna
openaire +4 more sources
Osteosarcoma: A Surveillance, Epidemiology, and End Results program‐based analysis from 1975 to 2017
Cancer, 2022 Osteosarcoma is the most common primary bone malignancy. As a rare cancer, population‐based studies remain small with limited information on finer demographic categories.
S. Cole +3 more
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Recent and Ongoing Research into Metastatic Osteosarcoma Treatments
International Journal of Molecular Sciences, 2022 The survival rate for metastatic osteosarcoma has not improved for several decades, since the introduction and refinement of chemotherapy as a treatment in addition to surgery.
Michael A. Harris, C. Hawkins
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2021 Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Although activator of HSP90 ATPase activity 1 (AHA1) is reported to be a potential oncogene, its role in osteosarcoma progression remains largely unclear ...
Diwei Zheng +13 more
doaj +1 more source
Frontiers in Oncology, 2022 Osteosarcoma is a kind of aggressive human malignancy, and the prognosis of the patients with osteosarcoma remains low. Studies have demonstrated that the tumor microenvironment plays a key role in regulating osteosarcoma progression. Recent studies have
Weidong Liu +4 more
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