Results 11 to 20 of about 116,442 (313)
Frontiers in Oncology, 2022 Osteosarcoma is a kind of aggressive human malignancy, and the prognosis of the patients with osteosarcoma remains low. Studies have demonstrated that the tumor microenvironment plays a key role in regulating osteosarcoma progression. Recent studies have
Weidong Liu +4 more
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Signal Transduction and Targeted Therapy, 2021 Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Although activator of HSP90 ATPase activity 1 (AHA1) is reported to be a potential oncogene, its role in osteosarcoma progression remains largely unclear ...
Diwei Zheng +13 more
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SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1
Stem Cells International, 2021 SOX12 plays a role in promoting the growth of some tumors; however, its role in osteosarcoma remains unclear. From gene expression omnibus (GEO) and tumor alterations relevant for genomics-driven therapy (TARGET) databases, Kaplan–Meier analyses were ...
Weifei Zhang +8 more
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miR-26a Reverses Multidrug Resistance in Osteosarcoma by Targeting MCL1
Frontiers in Cell and Developmental Biology, 2021 The multidrug resistance (MDR) acquired in human osteosarcoma is a huge obstacle for effective chemotherapy. Recently, microRNA-26a (miR-26a) has been associated with the pathogenesis and progression of osteosarcoma.
Ming Li, Wei Ma
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TMED3/RPS15A Axis promotes the development and progression of osteosarcoma
Cancer Cell International, 2021 Background Osteosarcoma is a primary malignant tumor that mainly affects children and young adults. Transmembrane emp24 trafficking protein 3 (TMED3) may be involved in the regulation of malignant cancer behaviors.
Wei Xu +6 more
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Longitudinal Latent Overall Toxicity (LOTox) profiles in osteosarcoma: a new taxonomy based on latent Markov models [PDF]
Statistical Methods and Applications (2024), 2021 Due to the presence of multiple types of adverse events with different levels of severity, the analysis of longitudinal toxicity data is a difficult task in cancer studies. In this work, a novel approach based on latent Markov models and compositional data techniques is proposed.
arxiv +1 more source
Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis
Journal of Translational Medicine, 2021 Background Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence,
Pengxu Shi, Yueting Li, Qingsheng Guo
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CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway
Frontiers in Oncology, 2022 Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the progression and metastasis of
Jun Cheng +9 more
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Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment [PDF]
Acta Biomaterialia. 65, 393-404 (2018), 2021 A novel multifunctional nanodevice based in doxorubicin (DOX)- loaded mesoporous silica nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has been developed for bone cancer treatment. These building blocks consists of: i) a polyacrylic acid (PAA) capping layer grafted to MSNs via an acid-cleavable acetal linker, to ...
arxiv +1 more source
Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia [PDF]
Mater. Sci. Eng. C. 91, 340-348 (2018), 2021 Nanographene oxide (nGO)-mediated hyperthermia has been increasingly investigated as a localised, minimally invasive anticancer therapeutic approach. Near InfraRed (NIR) light irradiation for inducing hyperthermia is particularly attractive, because biological systems mostly lack chromophores that absorb in this spectral window, facilitating the ...
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