Results 61 to 70 of about 482,563 (236)

Mutational spectrum and linkage disequilibrium patterns at the ornithine transcarbamylase gene (OTC)

, 2006
Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a hepatic enzyme involved in ammonia elimination via the urea cycle. Since the sequence of the OTC gene was reported many types of mutations continue to be found in OTC deficiency patients, continuing to ...
Diogo, L, Cenni, B, Soares, P A, Teles, E L, Wermuth, B, Azevedo, L, Martins, E, Vilarinho, L, Amorim, A, Quental, R, Garcia, P   +10 more
core   +1 more source

The Moral Manager in the Market: How CFOs' Ethical Intelligence Drives ESG Investment in Emerging Economies' Dual Markets

Business Strategy and the Environment, EarlyView.
ABSTRACT What propels a CFO in an emerging economy to champion ESG investments when formal regulations are weak? Moving beyond structural explanations, we provide a behavioural account arguing that a manager's internal ethical compass—moral intelligence (MI)—is a key driver.
AmirHossein ArminKia, Davood Askarany, Seyed Hamed Fahimifard, Seyedeh Kimia Shafahi Moghadam, Seyed Shayan Alavi   +4 more
wiley   +1 more source

Effizienz der Gentherapie mit adenoviralen Vektoren bei Ornithintranscarbamylse defizienten Mäusen in Abhängigkeit von OTC-Leadersequenz [PDF]

, 2003
Die Effizienz einer somatischen Gentherapie des Ornithintranscarbamylase-Mangels mit adenoviralen Vektoren wird am Modell der spfash-Maus untersucht. Spfash-Mäuse werden mit Vektoren transfiziert, die das komplette OTC-Transgen der Maus, des Menschen ...
Bendiks, M. (Meike)
core   +2 more sources

CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations

Molecular Therapy: Nucleic Acids, 2020
CRISPR-Cas9-mediated gene knockout and base-editing-associated induction of STOP codons (iSTOP) have been widely used to exterminate the function of a coding gene, while they have been reported to exhibit side effects.
Siyu Chen, Wanhua Xie, Zhiquan Liu, Huanhuan Shan, Mao Chen, Yuning Song, Hao Yu, Liangxue Lai, Zhanjun Li   +8 more
doaj   +1 more source

Intrabiliary infusion of naked DNA vectors targets periportal hepatocytes in mice

Molecular Therapy: Methods & Clinical Development, 2022
Hydrodynamic tail vein injection (HTV) is the “gold standard” for delivering naked DNA vectors to mouse liver, thereby transfecting predominately perivenous hepatocytes.
Sereina Deplazes, Andrea Schlegel, Zhuolun Song, Gabriella Allegri, Nicole Rimann, Tanja Scherer, Melanie Willimann, Lennart Opitz, Sharon C. Cunningham, Ian E. Alexander, Anja Kipar, Johannes Häberle, Beat Thöny, Hiu Man Grisch-Chan   +13 more
doaj   +1 more source

Ornithine transcarbamylase deficiency: A possible risk factor for thrombosis

, 2009
Ornithine transcarbamylase (OTC) deficiency is the most common urea cycle defect. Thromboembolic complications have not heretofore been linked with this diagnosis.
Lakshmi Venkateswaran, Scaglia, Fernando, Shchelochkov, Oleg A., Karpen, Saul, Hertel, Paula, Mahoney, Donald Jr, Oleg A. Shchelochkov, Donald L. Yee, Mclin, Valérie Anne, Saul Karpen, Fernando Scaglia, Paula Hertel, Donald Mahoney, Valerie McLin, Yee, Donald L., Venkateswaran, Lakshmi   +15 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

JHEP Reports, 2020
Background & Aims: Genome editing technology has immense therapeutic potential and is likely to rapidly supplant contemporary gene addition approaches.
Samantha L. Ginn, Anais K. Amaya, Sophia H.Y. Liao, Erhua Zhu, Sharon C. Cunningham, Michael Lee, Claus V. Hallwirth, Grant J. Logan, Szun S. Tay, Anthony J. Cesare, Hilda A. Pickett, Markus Grompe, Kimberley Dilworth, Leszek Lisowski, Ian E. Alexander   +14 more
doaj   +1 more source

Market formation and governance in international financial markets: The case of OTC derivatives [PDF]

, 2008
How are markets developed and governed? The article reviews four perspectives on the formation and development of markets and market governance — the political perspective (Fligstein), the network perspective (White), the framing perspective (Callon ...
Morgan, Glenn, Glenn Morgan
core   +1 more source

Ambient technology in epilepsy clinical practice

Epilepsia Open, EarlyView.
Abstract The utilization of large language model‐based artificial intelligence (AI) in the field of neurology has gained attention as a viable tool to enhance and assist providers with processes ranging from scheduling patients to providing preliminary interpretations of testing results, pending orders, and documenting encounters. Epileptologists could
Haania Kakwan, Justin F. Rousseau, Lidia M. Moura, Irfan S. Sheikh   +3 more
wiley   +1 more source