Results 71 to 80 of about 482,563 (236)

Adeno-Associated Virus(AAV)-Mediated Expression of Ornithine Transcarbamylase (OTC) in OTC Deficient spf-ash mMice [PDF]

Pediatric Research, 1999
Adeno-Associated Virus(AAV)-Mediated Expression of Ornithine Transcarbamylase (OTC) in OTC Deficient spf-ash ...
Xuehai Ye, Jeffrey Sachar, Elin Lisska, Weidong Xiao, Michael B Robinson, James M Wilson, Mark L Batshaw   +6 more
openaire   +1 more source

Urea Cycle Defects: Early-Onset Disease Associated with A208T Mutation in OTC Gene—Expanding the Clinical Phenotype

Case Reports in Genetics, 2017
Ornithine transcarbamylase deficiency (OMIM: 311250) is the most common disorder of urea cycle disorders, accounting for nearly 50% of all cases. We report a case of a two-month- old male patient, who attends our medical genetics consultation because of ...
Ana Isabel Sánchez, Alejandra Rincón, Mary García, Fernando Suárez-Obando   +3 more
doaj   +1 more source

Reduced citrulline availability by OTC deficiency in mice is related to reduced nitric oxide production.

, 2008
The amino acid arginine is the sole precursor for nitric oxide (NO) synthesis. We recently demonstrated that an acute reduction of circulating arginine does not compromise basal or lipopolysaccharide (LPS)-inducible NO production in mice.
Marcella M. Hallemeesch, Wouter J. de Jonge, Hallemeesch, M.M., Cornelis H. C. Dejong, Marcel C. van de Poll, Lamers, W.H., de Jonge, W.J., Luiking, Y.C., Wouter H. Lamers, van de Poll, M.C., Nicolaas E. P. Deutz, Deutz, N.E., Yvette C. Luiking, Dejong, C.H.   +13 more
core   +1 more source

The Sector Liquidity Timing Ability of Bond Mutual Funds

International Journal of Finance &Economics, EarlyView.
ABSTRACT We investigate whether bond mutual fund managers exhibit market liquidity timing skills in the U.S. corporate bond market. At the portfolio level, we find only weak evidence that bond funds adjust their overall market exposure in anticipation of changes in corporate bond market liquidity.
Zhengnan Yin, Niall O'Sullivan, Meadhbh Sherman, Yuting Chen   +3 more
wiley   +1 more source

Late-onset ornithine transcarbamylase deficiency: An under recognized cause of metabolic encephalopathy

SAGE Open Medical Case Reports, 2014
Introduction: Ornithine transcarbamylase deficiency is the most common inherited disorder of the urea cycle, has a variable phenotype, and is caused by mutations in the OTC gene.
Eric T Rush, Julianne E Hartmann, Jill C Skrabal, William B Rizzo   +3 more
doaj   +1 more source

Exchange Rates and Sovereign Risk: A Nonlinear Approach Based on Local Gaussian Correlations

International Journal of Finance &Economics, EarlyView.
ABSTRACT We empirically assess the interlinkages between sovereign risk, measured in terms of CDS spreads, and exchange rates for a sample of emerging markets. Our period of analysis includes episodes of severe stress, such as the Global Financial Crisis, the COVID‐19 pandemic, and the Ukrainian War.
Reinhold Heinlein, Gabriella D. Legrenzi, Scott M. R. Mahadeo   +2 more
wiley   +1 more source

オルニチン・トランスカルバミラーゼ (OTC) ケッソン (spf-ash) マウス エノ OTC イデンシ ドウニュウ [PDF]

, 1991
The sparse fur with abnormal skin and hair (spf-ash) mouse is a model for the human X linked hereditary disease， ornithine transcarbamylase (OTC) deficiency. It is characterized by hyperammonemia， orotic aciduria， lower serum citrulline and arginine， and
Shimada, Tokihiko, シマダ, トキヒコ, 島田, 辰彦, 125197   +3 more
core   +1 more source

Risk Forecasting in Shipping Exchange‐Traded‐Fund (ETF) Markets

International Journal of Finance &Economics, EarlyView.
ABSTRACT This article examines the risk properties of freight‐derivative‐based exchange‐traded funds (ETFs), focusing on the Breakwave Dry Bulk Shipping ETF (BDRY), and evaluates the accuracy of Value‐at‐Risk (VaR) and Expected Shortfall (ES) forecasts across a range of econometric models.
Christos Katris, Manolis G. Kavussanos, Stergiani (Stella) A. Moysiadou   +2 more
wiley   +1 more source

Mutation Spectrum and Genotype–Phenotype Correlation in a Cohort of Argentine Patients with Ornithine Transcarbamylase Deficiency: A Single-Center Experience

Journal of Inborn Errors of Metabolism and Screening, 2018
X-linked ornithine transcarbamylase deficiency (OTCD) is the most common urea cycle disorder. Hemizygous males with complete deficiency manifest neonatal acute hyperammonemia, while those with partial deficiency have a late presentation.
Laura E. Laróvere BSc, PhD, Silene M. Silvera Ruiz BSc, PhD, José A. Arranz MD, PhD, Raquel Dodelson de Kremer MD, PhD   +3 more
doaj   +1 more source

From cancer prevention to survivorship: Comprehensive menopause management after risk‐reducing salpingo‐oophorectomy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Risk‐reducing salpingo‐oophorectomy (RRSO) is the cornerstone of ovarian cancer prevention for women with hereditary cancer predisposition syndromes. When performed before natural menopause, however, RRSO induces immediate surgical menopause, with vasomotor symptoms, sexual dysfunction, accelerated bone loss, and potential long‐term ...
Agnaldo Lopes da Silva Filho, Giovanni Grandi, Teresa Lamaita Lopes, Matheus Eduardo Soares Pinhati, Angélica Nogueira Rodrigues, Fernando Cotait Maluf, Eduardo Batista Cândido, Rívia Mara Lamaita   +7 more
wiley   +1 more source