Results 111 to 120 of about 8,213 (210)

In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish

Frontiers in Pharmacology
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions.
Ethan Bustad, Emma Mudrock, Elizabeth M. Nilles, Andrea Mcquate, Andrea Mcquate, Andrea Mcquate, Monica Bergado, Alden Gu, Louie Galitan, Natalie Gleason, Henry C. Ou, Henry C. Ou, David W. Raible, David W. Raible, David W. Raible, Rafael E. Hernandez, Rafael E. Hernandez, Shuyi Ma, Shuyi Ma, Shuyi Ma, Shuyi Ma   +20 more
doaj   +1 more source

The audiogram: Detection of pure-tone stimuli in ototoxicity monitoring and assessments of investigational medicines for the inner ear. [PDF]

J Acoust Soc Am, 2022
Le Prell CG, Brewer CC, Campbell KCM.
europepmc   +1 more source

Development of a high-frequency hearing loss questionnaire for children [PDF]

, 2007
The Pediatric Assessment of Hearing questionnaire was developed to evaluate how children with high-frequency hearing loss perform in various listening ...
Baum, Jamie M.
core   +1 more source

Impact of Cisplatin on Hearing: Analysis Using PTA, High‐Frequency Audiometry, DPOAE, and Speech‐in‐Noise Test

OTO Open
Objective To assess hearing loss in patients with cancer receiving cisplatin‐based chemotherapy using high‐frequency pure tone average (HFPTA), distortion product otoacoustic emissions (DPOAEs), and the speech‐in‐noise (SPIN) test, and to identify ...
Juhi Irfana Basheer, Ramaswamy Balakrishnan, Poorvi V. Sharma, Madikeri Mohan Kishan, Karthik Udupa   +4 more
doaj   +1 more source

Determinants of efficacy and toxicity of aminoglycosides [PDF]

, 2017
The relative efficacy of different aminoglycosides or of different dosage schedules of the same aminoglycoside should be quantitated and related to relative toxicity.
Craig, W. A., Mattie, H., Pechèré, J. C.   +2 more
core  

The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals : 125. Toluene [PDF]

, 2000
The major route of toluene exposure is inhalation. Toluene is to a large extent metabolised in the liver and excreted in urine as hippuric acid. Toluene has a low acute toxicity. Toluene vapours causes complaints of eye irritation, headache and dizziness.
Östergaard, Grete
core  

Hearing thresholds at high frequency in patients with cystic fibrosis: a systematic review

Brazilian Journal of Otorhinolaryngology
Introduction: High-frequency audiometry may contribute to the early detection of hearing loss caused by ototoxic medications. Many ototoxic drugs are widely used in the treatment of patients with cystic fibrosis.
Debora T.M. Caumo, Lúcia B. Geyer, Adriane R. Teixeira, Sérgio S.M. Barreto   +3 more
doaj   +1 more source

Long-Term Variability of Distortion-Product Otoacoustic Emissions in Infants and Children and Its Relation to Pediatric Ototoxicity Monitoring. [PDF]

Ear Hear, 2020
Konrad-Martin D, Knight K, McMillan GP, Dreisbach LE, Nelson E, Dille M.   +5 more
europepmc   +1 more source

Ototoxicity: a high risk to auditory function that needs to be monitored in drug development

Frontiers in Molecular Neuroscience
Hearing loss constitutes a major global health concern impacting approximately 1.5 billion people worldwide. Its incidence is undergoing a substantial surge with some projecting that by 2050, a quarter of the global population will experience varying ...
Marie-Pierre Pasdelou, Lise Byelyayeva, Susanna Malmström, Sylvie Pucheu, Marie Peytavy, Hugo Laullier, Donald B. Hodges, Abraham R. Tzafriri, Gaëlle Naert   +8 more
doaj   +1 more source

Frequency, management and impact of adverse events on treatment outcomes in patients with multidrug resistant tuberculosis in Balochistan, Pakistan

Journal of Pharmaceutical Policy and Practice
Background: Early detection, monitoring, and managing adverse events (AEs) are crucial in optimising treatment for multidrug-resistant tuberculosis (MDR-TB) patients.Objectives: To investigate the incidence, factors, management, and impact of AEs on ...
Sara Rafique, Nafees Ahmad, Shereen Khan, Amjad Khan, Muhammad Atif, Abdul Wahid, Asad Khan, Hira Waheed   +7 more
doaj   +1 more source