Results 91 to 100 of about 8,213 (210)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, Volume 20, Issue 4, Page 920-932, April 2026.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Optimized Antimicrobial Dosing Strategies: A Survey of Pediatric Hospitals [PDF]
, 2014 Background Extended-interval aminoglycoside (EIAG) and extended- and continuous-infusion β-lactam (EIBL and CIBL) dosing strategies are increasingly used in adults, but pediatric literature is limited.
Cox, Elaine G. +2 more
core +2 more sources
Advanced Sensor Research, Volume 5, Issue 4, April 2026.Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically examines current therapeutic strategies for sensorineural hearing loss, including traditional drug and physical therapies as well as emerging stem cell and gene therapies, providing a ...
Ruirui Chen +3 more
wiley +1 more source
Plasma concentration monitoring of aminoglycosides [PDF]
, 2017 A narrow therapeutic margin and poor predictability of plasma concentrations are the main reasons for drug level monitoring during aminoglycoside treatment.
Follath, F., Vozeh, S., Wenk, M.
core
Adverse drug reaction and toxicity caused by commonly used antimicrobials in canine practice [PDF]
, 2014 An adverse drug reaction (ADR) is a serious concern for practicing veterinarians and other health professionals, and refers to an unintended, undesired and unexpected response to a drug that negatively affects the patient's health.
Barranco +10 more
core +1 more source
Aggregate, Volume 7, Issue 4, April 2026.This review summarizes recent advances in integrated point‐of‐care testing (POCT) systems for public health, encompassing isothermal nucleic acid amplification, CRISPR‐based signal amplification, device integration, and chemometric/artificial intelligence‐assisted data interpretation, with applications in infectious disease surveillance, food and ...
Yan Du, Jiaqi Li, Jinghong Li
wiley +1 more source
Long-Term Effects of the Synergistic Interaction of Cisplatin and Noise [PDF]
, 2015 As cancer treatments advance, more patients survive each year. Of these survivors, many have experienced treatment with chemotherapeutic drugs like cisplatin that have aided in and enabled their recovery. Cisplatin, a chemotherapeutic drug used to combat
DeBacker, J. Riley
core
OtoID: New extended frequency, portable audiometer for ototoxicity monitoring
Journal of Rehabilitation Research and Development, 2013 Portability of equipment is an increasingly important component in the practice of audiology. We report on a new device, the OtoID, that supports evidence-based ototoxicity testing protocols, provides capability for hearing testing on the hospital treatment unit, and can automate patient self-testing.
Marilyn F, Dille +4 more
openaire +2 more sources
Human Brain Mapping, Volume 47, Issue 5, 1 April 2026.Long‐term hearing loss with cognitive decline shows altered brain gradients, enlarged choroid plexus, and ventricles. These are linked to transcriptomic changes in synaptic, metabolic, and neurodegenerative pathways. ABSTRACT Long‐term sensorineural hearing loss (SNHL) is a prevalent condition associated with an increased risk of cognitive impairment ...
Xiao‐Min Xu +8 more
wiley +1 more source
Finding ways to solve or prevent aminoglycoside-induced ototoxicity? [PDF]
, 2016 published_or_final_versio
Li, J, Woo, WHC
core +1 more source