Results 71 to 80 of about 4,446,831 (170)

Temporal Modulation Enhances Medial Olivocochlear Reflex Efficacy: A TEOAE Suppression Study With Amplitude‐Modulated Broadband Noise

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Introduction The medial olivocochlear reflex (MOCR), an efferent feedback pathway, modulates cochlear gain to enhance signal detection in noise. It is commonly assessed non‐invasively via contralateral suppression of transient‐evoked otoacoustic emissions (TEOAEs). While unmodulated noise is a standard elicitor, ecologically relevant amplitude‐
İrem Sendesen, İrem Karakuluk
wiley   +1 more source

Risk versus benefit: Who assesses this in the management of patients on ototoxic drugs?

Journal of Pharmacy and Bioallied Sciences, 2017
The current paper is an attempt at highlighting important strategic indicators, as well as important variables, that the audiology community needs to consider in order to play a more central role in pharmaco-vigilance as part of pharmaco-audiology ...
Katijah Khoza-Shangase
doaj   +1 more source

The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent Radiotherapy With Cetuximab due to Contraindications With Cisplatin

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Purpose Patients unable to receive cisplatin due to age, comorbidities, or reduced performance status are commonly treated with concurrent radiotherapy (RT) and cetuximab. This study evaluated the prognostic significance of the Geriatric 8 (G8) score and the Charlson Comorbidity Index (CCI) in predicting survival outcomes in this population ...
Esin Kiraz, Mete Gündoğ, Rıdvan Gönül, İrfan Kara, İmdat Yüce, Sedat Çağlı   +5 more
wiley   +1 more source

Otoacoustic Emissions for Monitoring Aminoglycoside-Induced Ototoxicity in Children With Cystic Fibrosis [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2002
To investigate whether transient-evoked and distortion-product (DP) otoacoustic emissions (OAEs) are more sensitive than pure-tone audiometry (PTA) in revealing gentamicin-induced ototoxicity in children with cystic fibrosis (CF).Prospective case-control study.Tertiary referral audiologic center in conjunction with an academic pediatric CF unit.The ...
Stavroulaki, P, Vossinakis, IC, Dinopoulou, D, Doudounakis, S, Adamopoulos, G, Apostolopoulos, N   +5 more
openaire   +3 more sources

Longitudinal Evaluation of Otoacoustic Emissions as a Screening Tool for High‐Frequency Hearing Loss in Adolescents

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 2, Page 480-486, August 2026.
Abstract Objective To investigate the association between distortion product otoacoustic emission (DPOAE) signal‐to‐noise ratios (SNRs) and pure‐tone audiometry (PTA) thresholds in adolescents, both cross‐sectionally at age 18 and longitudinally by evaluating whether DPOAE SNRs at age 13 predict high‐frequency hearing loss (HFHL) at age 18.
Stefanie N. H. Reijers, Angeline E. Meerkerk‐Meijer, Jantien L. Vroegop, Geert Geleijnse, Bernd Kremer, Marc P. van der Schroeff   +5 more
wiley   +1 more source

Cisplatin associated ototoxicity in patients receiving cancer chemotherapy in a tertiary care hospital

National Journal of Physiology, Pharmacy and Pharmacology, 2020
Background: Cisplatin-based treatment regimen has been a gold standard in the treatment of various solid tumors. Ototoxicity is a very serious adverse effect of cisplatin therapy in either high or low dose regimens.
Nalini R, Ezhilramya J, Arumugham R, Suresh Kumar R, Celiba G   +4 more
doaj   +1 more source

Selumetinib as a Target Therapy in Progressive Paediatric Low‐Grade Gliomas—Case Series (pLGG)

Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1499-1508, August 2026.
ABSTRACT Background Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1 (NF1). While smaller gliomas may be only monitored, the current standard of care for symptomatic ones relies on chemotherapy, most commonly carboplatin and vincristine.
Laura Trapani, Giulia Gortani, Andrea Magnolato, Flora Maria Murru, Elisabetta Cattaruzzi, Laura Diplotti, Paola Michieletto, Silvia Giganti, Davide Zanon, Alessandra Maestro, Valentina Kiren, Egidio Barbi, Irene Bruno   +12 more
wiley   +1 more source

Extended-Interval Dosing of Aminoglycosides in Pediatrics: A Narrative Review

Journal of Pediatrics Review, 2015
Aminoglycosides (AGs) are frequently used in pediatric settings, especially for empiric treatment of early-onset neonatal sepsis. Although AGs are used for several decades, the optimum method of administration and their dosing schemes needs more ...
Ebrahim Salehifar, Mohammad Reza Rafati
doaj   +2 more sources

Ototoxicity and otoprotection in the inner ear of guinea pigs using gentamicin and amikacin: ultrastructural and functional aspects

Brazilian Journal of Otorhinolaryngology, 2008
Summary: Ototoxicity is still a challenge to medicine. The discovery of self-protecting endogenous mechanisms of the outer hair cells associated with their functional and ultra-structural assessment methods has opened new horizons in the understanding ...
Thomaz José Marra de Aquino, José Antônio Apparecido de Oliveira, Maria Rossato   +2 more
doaj   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2028-2048, July 2026.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source