Results 71 to 80 of about 2,606,163 (178)

A Population Pharmacokinetic Model of Gentamicin in Hospitalized Neonatal Foals

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Information on safe and effective gentamicin dosing in foals is limited. This study aimed to provide guidance regarding optimal dosing regimens by means of a population pharmacokinetic (popPK) model. Gentamicin plasma concentration of 290 samples from 72 hospitalized foals (≤ 14 days old), treated with intravenous (IV) gentamicin, was measured
Astrid J. van den Brom‐Spierenburg, Esther A. Winter, Mathijs J. P. Theelen, Ingeborg M. van Geijlswijk, Cornélie M. Westermann, Marianne M. Sloet van Oldruitenborgh‐Oosterbaan, Tim Florschütz, Johannes C. Vendrig, Esther W. Siegers, Kim de Graaf, Marc Cherlet, Mathias Devreese, Ronette Gehring   +12 more
wiley   +1 more source

Role of otoacoustic emissions in the early detection and prevention of ototoxicity

Journal of Marine Medical Society, 2018
Introduction: Evaluating Otoacoustic Emissions (OAEs) is one of the audiological methods for ototoxicity monitoring. The absence of OAEs indicates cochlear damage.
Anil Kaul, Tarun Malhotra, Shazia Khan
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Emerging Distortion Product Otoacoustic Emission Techniques to Identify Preclinical Warning Signs of Basal Cochlear Dysfunction Due to Ototoxicity

Applied Sciences, 2019
Hundreds of medications commonly prescribed for anticancer treatments and some infections are known to cause hearing damage, referred to as ototoxicity.
Gayla L. Poling, Brittany Vlosich, Laura E. Dreisbach   +2 more
doaj   +1 more source

Cisplatin-associated ototoxicity amongst cervical cancer patients: A prospective cohort study in south Africa.

PLoS ONE, 2023
BackgroundConcurrent chemoradiotherapy using weekly cisplatin remains standard of care for locally advanced cervical cancer in Sub-Saharan Africa. While cisplatin remains a popular cancer chemotherapeutic, it has an irreversible ototoxic effect on ...
Jessica Paken, Cyril Devadas Govender, Mershen Pillay, Merga Feyasa, Vikash Sewram   +4 more
doaj   +1 more source

Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]

, 2015
Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Paromita Majumder, Majumder, P, Duchen, MR, Jonathan E. Gale, Michael R. Duchen, Gale, JE   +5 more
core   +1 more source

Machine Learning‐Based Risk Stratification Tool for Hearing Loss in High‐Risk Neonates

The Laryngoscope, Volume 136, Issue 11, Page 4755-4764, November 2026.
Machine learning models, particularly XGBoost, provide robust risk stratification for neonatal hearing loss by capturing complex interactions among clinical risk factors such as NICU stay duration and family history. To translate these predictive capabilities into routine practice, an open‐access web‐based clinical decision support tool was developed ...
Sevgi Kutlu, Emre Söylemez, Betül Temir, Esranur Ulusoy, Zahide Çiler Büyükatalay   +4 more
wiley   +1 more source

Early Outer Hair Cell Dysfunction Associated With Educational Noise Exposure in Dental Students: Implications for Hearing Conservation in Dental Education

European Journal of Dental Education, Volume 30, Issue 4, Page 1869-1879, November 2026.
ABSTRACT Introduction Dental education involves continuous exposure to high‐frequency noise from clinical instruments, which may cause early outer hair cell damage even before professional practice begins. While noise‐induced hearing loss (NIHL) is a recognised occupational hazard among dentists, evidence regarding subclinical outer hair cell changes ...
Merve Yelken Kendirci, Mehtap Ungor, Handan Turan Dizdar, Ahmet Faruk Erturk, Ilknur Ozcan   +4 more
wiley   +1 more source

Otoacoustic Emissions for Monitoring Aminoglycoside-Induced Ototoxicity in Children With Cystic Fibrosis [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2002
To investigate whether transient-evoked and distortion-product (DP) otoacoustic emissions (OAEs) are more sensitive than pure-tone audiometry (PTA) in revealing gentamicin-induced ototoxicity in children with cystic fibrosis (CF).Prospective case-control study.Tertiary referral audiologic center in conjunction with an academic pediatric CF unit.The ...
Stavroulaki, P, Vossinakis, IC, Dinopoulou, D, Doudounakis, S, Adamopoulos, G, Apostolopoulos, N   +5 more
openaire   +3 more sources

Ototoxic drugs, diagnosis and monitoring

, 2019
Ototoxicity is a cochlear or vestibular dysfunction caused by chemical, physical or biological effects. It affects the internal ear and hearing nerve and might be reversible or irreversible.
Tan M., Toplu Y.
core   +1 more source