Results 51 to 60 of about 8,213 (210)

Using tablet-based technology to deliver time-efficient ototoxicity monitoring [PDF]

International Journal of Audiology, 2017
The goal of this article is to highlight mobile technology that is not yet standard of care but could be considered for use in an ototoxicity monitoring programme (OMP) as an adjunct to traditional audiometric testing. Current guidelines for ototoxicity monitoring include extensive test protocols performed by an audiologist in an audiometric booth ...
Douglas, Brungart, Jaclyn, Schurman, Dawn, Konrad-Martin, Kelly, Watts, Jay, Buckey, Odile, Clavier, Peter G, Jacobs, Samuel, Gordon, Marilyn F, Dille   +8 more
openaire   +2 more sources

Healthcare professionals’ knowledge and practices in managing ototoxicity in children with cancer

South African Journal of Communication Disorders
Background: Platinum-based chemotherapy poses a risk of ototoxic hearing loss, the effects of which can be devastating in paediatrics with cancer. Childhood hearing loss significantly impacts speech and language acquisition, and educational, psychosocial
Kajal Ramnarian, Jessica Paken
doaj   +1 more source

Cisplatin-Associated Ototoxicity: A Review for the Health Professional

Journal of Toxicology, 2016
Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life.
Jessica Paken, Cyril D. Govender, Mershen Pillay, Vikash Sewram   +3 more
doaj   +1 more source

High incidence of cisplatin-induced ototoxicity in paediatric patients in the Western Cape, South Africa

South African Journal of Oncology, 2018
Background: Fourteen million new cancer cases are reported annually, and up to 10% of those involve children below 15 years. Cisplatin, a commonly used anti-cancer drug for its high success rate, is associated with ototoxicity.
Mukovhe Phanguphangu, Lebogang Ramma
doaj   +1 more source

Ototoxicidad en pacientes oncológicos: experiencia y propuesta de un protocolo de vigilancia

Anales de Pediatría, 2021
Resumen: Introducción: La ototoxicidad se presenta en diversos porcentajes según estudios tras el tratamiento con quimioterapia basada en platino y/o radioterapia craneal.
Mario Sánchez-Canteli, Faustino Núñez-Batalla, Patricia Martínez-González, Ana de Lucio-Delgado, José Antonio Villegas-Rubio, Justo Ramón Gómez-Martínez, José Luis Llorente-Pendás   +6 more
doaj   +1 more source

An overview of pharmacotherapy-induced ototoxicity

South African Family Practice, 2013
This article provides an overview of ototoxic medication, as well as different pharmacological and audiological monitoring strategies. Although ototoxic medications play an important role in modern medicine, they also have the capacity to do great harm ...
Natalie Schellack, Alida Naude
doaj   +1 more source

Cisplatin-associated ototoxicity amongst cervical cancer patients: A prospective cohort study in south Africa.

PLoS ONE, 2023
BackgroundConcurrent chemoradiotherapy using weekly cisplatin remains standard of care for locally advanced cervical cancer in Sub-Saharan Africa. While cisplatin remains a popular cancer chemotherapeutic, it has an irreversible ototoxic effect on ...
Jessica Paken, Cyril Devadas Govender, Mershen Pillay, Merga Feyasa, Vikash Sewram   +4 more
doaj   +1 more source

Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses [PDF]

, 2012
BACKGROUND AND PURPOSEExposure to an ototoxic level of an aminoglycoside can result in hearing loss. In this we study investigated the otoprotective efficacy of dexamethasone (DXM), melatonin (MLT) and tacrolimus (TCR) in gentamicin (GM)-treated animals ...
Bas, E, Dinh, J, Gupta, C, Láinez Andrés, José Miguel, Marco, J, Martínez-Soriano, F, Van De Water, TR, Vu, L   +7 more
core   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source