Results 61 to 70 of about 4,446,831 (170)

Cisplatin-associated ototoxicity amongst cervical cancer patients: A prospective cohort study in south Africa.

PLoS ONE, 2023
BackgroundConcurrent chemoradiotherapy using weekly cisplatin remains standard of care for locally advanced cervical cancer in Sub-Saharan Africa. While cisplatin remains a popular cancer chemotherapeutic, it has an irreversible ototoxic effect on ...
Jessica Paken, Cyril Devadas Govender, Mershen Pillay, Merga Feyasa, Vikash Sewram   +4 more
doaj   +1 more source

Ototoxicidad en pacientes oncológicos: experiencia y propuesta de un protocolo de vigilancia

Anales de Pediatría, 2021
Resumen: Introducción: La ototoxicidad se presenta en diversos porcentajes según estudios tras el tratamiento con quimioterapia basada en platino y/o radioterapia craneal.
Mario Sánchez-Canteli, Faustino Núñez-Batalla, Patricia Martínez-González, Ana de Lucio-Delgado, José Antonio Villegas-Rubio, Justo Ramón Gómez-Martínez, José Luis Llorente-Pendás   +6 more
doaj   +1 more source

Ménière's Disease: A Tri‐Decade Scoping Review of Treatment Trends and Evidence Quality

The Laryngoscope, EarlyView.
This tri‐decade scoping review of Ménière's disease literature reveals a significant increase in high‐level evidence and a clinical pivot toward hearing‐preserving interventions, such as intratympanic steroids and cochlear implants. However, a significant quality paradox has emerged, where adherence to standardized AAO‐HNS reporting and diagnostic ...
Ofir Zavdy, Teeraya Piyajarawong, Seamus Boyle, Ross O'Shea, John Rutka   +4 more
wiley   +1 more source

Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa

Frontiers in Neurology
BackgroundAminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity.
Adebolajo A. Adeyemo, Adebolajo A. Adeyemo, Babatunde Adedokun, Josephine Adeolu, Joshua O. Akinyemi, Olayemi O. Omotade, Odunayo M. Oluwatosin   +6 more
doaj   +1 more source

Emerging Distortion Product Otoacoustic Emission Techniques to Identify Preclinical Warning Signs of Basal Cochlear Dysfunction Due to Ototoxicity

Applied Sciences, 2019
Hundreds of medications commonly prescribed for anticancer treatments and some infections are known to cause hearing damage, referred to as ototoxicity.
Gayla L. Poling, Brittany Vlosich, Laura E. Dreisbach   +2 more
doaj   +1 more source

A Systematic Review of Topical and Systemic Gentamicin for Wound Healing in Patients With Junctional and Dystrophic Epidermolysis Bullosa

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Epidermolysis bullosa (EB) is an inherited mechanobullous genodermatosis caused by a mutation in genes encoding proteins integral to skin integrity. Premature termination codon readthrough therapies, such as gentamicin, have promise in facilitating full‐length protein expression in patients with EB.
Kelvin Truong, Joseph Joseph, Deborah Poh, Orli Wargon, Artiene Tatian   +4 more
wiley   +1 more source

Monitoring Ototoxicity through Otoacoustic Emissions. Present, COVID-19, and Future Related Insights

, 2020
The administration of certain drugs is directly related to inner ear damage. Due to the potential of these elements and their usage, more extensive monitoring of adverse effects should be implemented. That is why, baseline evaluation for ototoxicity must
G. Panagiotopoulos
semanticscholar   +1 more source

Advances in the treatment of systemic lupus erythematosus: Biologicals, small‐molecular agents, and cell‐depleting therapies coming to the clinic

Journal of Internal Medicine, EarlyView.
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2834-2852, August 2026.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Distortion-Product Otoacoustic Emission Test Performance for Ototoxicity Monitoring [PDF]

Ear & Hearing, 2011
A nonbehavioral method for monitoring ototoxicity in patients treated with cisplatin is needed because patients enduring chemotherapy may not be well or cooperative enough to undergo repeated hearing tests. Distortion-product otoacoustic emissions (DPOAEs) provide a nonbehavioral measure of auditory function that is sensitive to cisplatin exposure ...
Kelly M, Reavis, Garnett, McMillan, Donald, Austin, Frederick, Gallun, Stephen A, Fausti, Jane S, Gordon, Wendy J, Helt, Dawn, Konrad-Martin   +7 more
openaire   +2 more sources