Results 61 to 70 of about 8,213 (210)

Gentamicin, genetic variation and deafness in preterm children. [PDF]

, 2014
Hearing loss in children born before 32 weeks of gestation is more prevalent than in full term infants. Aminoglycoside antibiotics are routinely used to treat bacterial infections in babies on neonatal intensive care units.
Bitner-Glindzicz, M, Chant, K, Marlow, N, Rahman, S   +3 more
core   +2 more sources

Role of otoacoustic emissions in the early detection and prevention of ototoxicity

Journal of Marine Medical Society, 2018
Introduction: Evaluating Otoacoustic Emissions (OAEs) is one of the audiological methods for ototoxicity monitoring. The absence of OAEs indicates cochlear damage.
Anil Kaul, Tarun Malhotra, Shazia Khan
doaj   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Systemic aminoglycosides-induced vestibulotoxicity in humans

, 2017
Objectives: This systematic review aimed to investigate the prevalence and characteristics of vestibular adverse effects of aminoglycoside (AG) therapy in humans and to analyze objective vestibular tests for the detection of AG-induced vestibulotoxicity.
Agrawal, Ahmed, Ahmed, Ahmed, Al-Malky, Ariano, Aust, Barza, Black, Black, Black, Caminero, Carey, Chen, Chiodo, Colebatch, Curthoys, Davis, Deka, Demer, Dobie, Elfving, Esterhai, Eviatar, Farzal, Fausti, Fee, Finitzo-Hieber, Forge, Fujimoto, Gendeh, Gendeh, Geyer, Gibson, Goldberg, Gonçalves, Govaerts, Grohskopf, Guinand, Hain, Halmagyi, Halmagyi, Hauch, Hermann, Hinshaw, Huizing, Ishiyama, Ishiyama, Kahlmeter, Kim, Landis, Lehmann, Leis, Lerner, Li, Liberati, Lindeman, Liu, Lucieer, Lue, Lyford-Pike, Maes, Maes, Matz, McCaslin, Mendel, Minor, Nakashima, Noone, Pedersen, Petersen, Pillers, Poirrier, Prayle, Price, Rizzi, Rogers, Rosengren, Rybak, Schacht, Schatz, Scheenstra, Selimoglu, Selimoğlu, Stavroulaki, Stevenson, Sun, Sun, Tange, Thomas, Tjernström, Tjernström, Tsuji, van de Berg, Vasquez, Venhovens, Ward, Weber, Winkel, Wuyts, Wuyts, Zagólski, Zingler   +102 more
core   +1 more source

Bayesian estimation of tobramycin exposure in cystic fibrosis [PDF]

, 2016
Fixed tobramycin (mg/kg) dosing is often inappropriate in patients with cystic fibrosis (CF), as pharmacokinetics are highly variable. The area under the concentration-time curve (AUC) is an exposure metric suited to monitoring in this population ...
Barras, Michael A., Hennig, Stefanie, Jess, Katrina, Norris, Ross L. G., Serisier, David   +4 more
core   +1 more source

Emerging Distortion Product Otoacoustic Emission Techniques to Identify Preclinical Warning Signs of Basal Cochlear Dysfunction Due to Ototoxicity

Applied Sciences, 2019
Hundreds of medications commonly prescribed for anticancer treatments and some infections are known to cause hearing damage, referred to as ototoxicity.
Gayla L. Poling, Brittany Vlosich, Laura E. Dreisbach   +2 more
doaj   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Impact of drug-resistant tuberculosis treatment on hearing function in South African adults: Bedaquiline versus kanamycin

South African Journal of Communication Disorders, 2021
Background: Ototoxicity linked to medications used to treat tuberculosis (TB) remains a global challenge. Objectives: The aim was to describe the audiological function in a group of adults with drug-resistant tuberculosis (DR-TB) on bedaquiline (G-BDQ ...
Katijah Khoza-Shangase, Marina Prodromos
doaj   +1 more source

Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim, Amy Thachil, Kelly McMahon, Ross T. Tsuyuki, S. Rod Rassekh, Lesley G. Mitchell, Prasad Devarajan, Cherry Mammen, Bruce C. Carleton, Geoffrey D. E. Cuvelier, Victor A. Lewis, Colin J. D. Ross, Alexandra P. Zorzi, Sylvain Baruchel, Raveena Ramphal, Eric Bouffet, Mathieu Lemaire, Tom D. Blydt‐Hansen, Brad L. Urquhart, The Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group, Tom Blydt‐Hansen, Bruce C. Carleton, Geoff D. E. Cuvelier, Sunil Desai, Prasad Devarajan, Conrad Fernandez, Adam Fleming, Paul Gibson, Caroline Laverdiere, Victor Lewis, Mary L. McBride, Bruno Michon, Shahrad Rod Rassekh, Colin J. D. Ross, Christine Sabapathy, Kirk R. Schultz, Michael Zappitelli, Alexandra Zorzi   +37 more
wiley   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen, Irvine, Sharon C., Jones, Brian L., Ritchie, Neil D., Robb, Fiona, Seaton, R. Andrew   +5 more
core   +1 more source