Results 61 to 70 of about 2,606,163 (178)

Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim, Amy Thachil, Kelly McMahon, Ross T. Tsuyuki, S. Rod Rassekh, Lesley G. Mitchell, Prasad Devarajan, Cherry Mammen, Bruce C. Carleton, Geoffrey D. E. Cuvelier, Victor A. Lewis, Colin J. D. Ross, Alexandra P. Zorzi, Sylvain Baruchel, Raveena Ramphal, Eric Bouffet, Mathieu Lemaire, Tom D. Blydt‐Hansen, Brad L. Urquhart, The Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group, Tom Blydt‐Hansen, Bruce C. Carleton, Geoff D. E. Cuvelier, Sunil Desai, Prasad Devarajan, Conrad Fernandez, Adam Fleming, Paul Gibson, Caroline Laverdiere, Victor Lewis, Mary L. McBride, Bruno Michon, Shahrad Rod Rassekh, Colin J. D. Ross, Christine Sabapathy, Kirk R. Schultz, Michael Zappitelli, Alexandra Zorzi   +37 more
wiley   +1 more source

Standardizing Aminoglycoside Induced Ototoxicity Monitoring

, 2019
Aminoglycoside (AG) antibiotics are essential for the treatment of cystic fibrosis (CF) lung infections. Pseudomonas aeruginosa. Nontuberculous mycobacteria. Monitoring is critical secondary to potential nephrotoxicity and ototoxicity.
Meier, Ellen, Duehlmeyer, Stephanie, Oermann, Christopher M, Elson, Claire   +3 more
core   +1 more source

Standardizing ototoxicity monitoring for children treated with cisplatin: an urgent call to action

Frontiers in Oncology
Over the past 25 years, considerable progress has been made in identifying the prevalence, risk factors, functional impacts, and protective strategies for cisplatin-induced ototoxicity.
Kristin Knight, Milanka Drenovak, Thorsten Langer, Nienke Streefkerk, Tri Juda Airlangga, Murti Andriastuti, Asmarinah, Deborah Berndtson, Adwina Nurlita Kusuma Wardhani Hartantyo, Alexander E. Hoetink, Alexander E. Hoetink, Kim E. de Jager, Dawn Konrad Martin, Dawn Konrad Martin, Cimi Ilmiawati, M. Tayyar Kalcioglu, Ika Dewi Mayangsari, Nyilo Purnami, Shally Adhina Putri, Haldun Oguz, Irene Schmid, Rasjid Soeparwata, Helen Spoudeas, Anna-Katharina Rohlfs, Kaukab Rajput, Penelope Brock, Marry M. van den Heuvel-Eibrink, Antoinette am Zehnhoff-Dinnesen   +27 more
doaj   +1 more source

Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity

, 2015
OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity.
Demir, Mehmet Gökhan, Sedat Aydin, Kayhan Basak, BASAK, Kayhan, Aydin, Sedat, Niyazi Altintoprak, Ebru Kosemihal, Kosemihal, Ebru, ALTINTOPRAK, Niyazi, Mehmet Gokhan Demir   +9 more
core   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Early detection of platinum-induced ototoxicity in adults

B-ENT, 2017
Early detection of platinum-induced ototoxicity in adults. Problems/objectives: Multiple toxicities, including ototoxicity, have been reported for patients treated with the widely used, anti-solid tumour agent, cisplatin.
E. D’heygere, R. Kuhweide, H. Pottel, L. Mus, T. Vauterin, Bob Lerut   +5 more
doaj   +2 more sources

A Systematic Review of Topical and Systemic Gentamicin for Wound Healing in Patients With Junctional and Dystrophic Epidermolysis Bullosa

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Epidermolysis bullosa (EB) is an inherited mechanobullous genodermatosis caused by a mutation in genes encoding proteins integral to skin integrity. Premature termination codon readthrough therapies, such as gentamicin, have promise in facilitating full‐length protein expression in patients with EB.
Kelvin Truong, Joseph Joseph, Deborah Poh, Orli Wargon, Artiene Tatian   +4 more
wiley   +1 more source

Distortion-Product Otoacoustic Emission Test Performance for Ototoxicity Monitoring [PDF]

Ear & Hearing, 2011
A nonbehavioral method for monitoring ototoxicity in patients treated with cisplatin is needed because patients enduring chemotherapy may not be well or cooperative enough to undergo repeated hearing tests. Distortion-product otoacoustic emissions (DPOAEs) provide a nonbehavioral measure of auditory function that is sensitive to cisplatin exposure ...
Kelly M, Reavis, Garnett, McMillan, Donald, Austin, Frederick, Gallun, Stephen A, Fausti, Jane S, Gordon, Wendy J, Helt, Dawn, Konrad-Martin   +7 more
openaire   +2 more sources