Results 81 to 90 of about 4,708 (180)
Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.We investigated the role of a continuous, quantitative intraoperative monitoring system in surgeries for facial nerve schwannomas, a rare tumor associated with a high risk of facial nerve dysfunction. By continuously stimulating the facial nerve and recording electromyographic responses in real time, the system enabled surgeons to detect subtle or ...
Makoto Hosoya +7 more
wiley +1 more source
Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.ABSTRACT Purpose Treatment adherence is a key determinant of outcomes in cancer patients and is influenced by multiple clinical and social factors. Hearing loss (HL) may contribute to communication barriers and treatment disruption. This study aimed to evaluate the relationship between HL and treatment adherence.
Bilgeşah Kılıçtaş +8 more
wiley +1 more source
Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang +6 more
wiley +1 more source
AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model
Sensory Neuroscience, Volume 2, Issue 2, June 2026.Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou +6 more
wiley +1 more source
Audiologic monitoring of ototoxicity
, 2005 Ototoksisite, çe.itli terapötik ajanların veya kimyasal maddelerin iç kulak yapılarında veya fonksiyonlarında hasar yaratma etkisi olarak tanımlanabilir. Etkilenen kısım koklea, vestibül veya her ikisi olabilir. Ototoksisitenin başlıca semptomları işitme
Yağız, Recep, Taş, Abdullah
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Hearing loss amongst DR-TB patients that have received extended high-frequency pure tone audiometry monitoring (KUDUwave) at three DR-TB decentralized sites in Kwazulu Natal [PDF]
, 2018 Magister Public Health - MPHOtotoxic induced hearing loss is a common adverse event related to aminoglycosides used in Multi Drug Resistant -Tuberculosis treatment. Exposure to ototoxic drugs damages the structures of the inner ear.
Rudolph-Claasen, Zerilda Suzette
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Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, Volume 13, Issue 29, 22 May 2026.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
Ototoxicity management and cystic fibrosis (Garinis et al., 2021)
, 2021 Purpose: Specific classes of antibiotics, such as aminoglycosides, have well-established adverse events producing permanent hearing loss, tinnitus, and balance and/or vestibular problems (i.e., ototoxicity). Although these antibiotics are frequently used
Peter S. Steyger (11437436) +20 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1457-1472, May 2026.Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo +10 more
wiley +1 more source
Ototoxic drugs, diagnosis and monitoring
, 2019 Ototoxicity is a cochlear or vestibular dysfunction caused by chemical, physical or biological effects. It affects the internal ear and hearing nerve and might be reversible or irreversible.
Tan M., Toplu Y.
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