Results 81 to 90 of about 8,213 (210)

Ototoxicity and otoprotection in the inner ear of guinea pigs using gentamicin and amikacin: ultrastructural and functional aspects

Brazilian Journal of Otorhinolaryngology, 2008
Summary: Ototoxicity is still a challenge to medicine. The discovery of self-protecting endogenous mechanisms of the outer hair cells associated with their functional and ultra-structural assessment methods has opened new horizons in the understanding ...
Thomaz José Marra de Aquino, José Antônio Apparecido de Oliveira, Maria Rossato   +2 more
doaj   +1 more source

Vancomycin intoxication in a patient with inappropriate antidiuretic hormone syndrome and diarrhea [PDF]

Farmacia Hospitalaria, 2015
Vancomycin is an antibiotic used for infections by gram-positive bacteria with a two-compartment pharmacokinetic model. Its monitoring has an established therapeutic range (10-20 mg/L) to prevent nephrotoxicity and ototoxicity due to supratherapeutic ...
Patricia Hidalgo-Collazos, Cristina López González-Cobos, Paula Arrabal-Durán, María Sanjurjo-Sáez   +3 more
doaj   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1457-1472, May 2026.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Molecular Mechanisms of Resistance and Treatment Efficacy of Delamanid Against Mycobacterium tuberculosis: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug‐resistant tuberculosis (MDR‐TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug‐susceptible and drug‐resistant Mycobacterium tuberculosis (Mtb) strains.
Md. Mahmudul Islam, Md. Zahid Hasan, Md. Touki Tahamid Tusar, Md. Yeamin Hossain, Md. Motaher Hossain, Md. Abdulla Al Jubayed, Md. Jubaer‐Al‐Abedin, Sheikh Soikot, Shanzida Akther, Jahid Bhuyian, Hafizur Rahman Gazi, B. M. Mahmudul Hasan, Md. Shofiul Azam, Md. Enamul Haque, Abdullah‐Al‐Jubayer, Md. Faruk Hasan, F. M. Ali Haydar, Md. Khalekuzzaman, Md. Torequl Islam, Sohel Hasan   +19 more
wiley   +1 more source

Efficacy of the Speech Intelligibility Index as an intervention tool with pediatric cancer patients [PDF]

, 2010
This study evaluates the Speech Intelligibility Index (SII) as a tool to describe hearing loss and predict when hearing aids would be appropriate for pediatric oncology patients who have received or are currently receiving cisplatin.
Cahill, Megan
core   +1 more source

Highly active antiretroviral therapy: Does it Sound toxic?

Journal of Pharmacy and Bioallied Sciences, 2011
Objective : The main objective of the current study is to monitor the auditory status in a group of adults with AIDS, receiving Highly Active Antiretroviral Therapy (HAART) (3TC -lamivudine, D4T - stavudine, and efavirenz) in a hospital outpatient clinic
Katijah Khoza-Shangase
doaj   +1 more source

Rate of Hearing Loss in Platinum‐Naïve Patients Receiving Immune Checkpoint Inhibitors

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1289-1297, May 2026.
Abstract Objective Hearing loss from immune checkpoint inhibitors (ICIs) has been documented in case reports and case series. We present the largest retrospective study investigating the rate of ICI‐related ototoxicity in a monitored cohort of platinum‐naïve patients. Study Design Retrospective cohort study. Setting Tertiary‐care center.
Kaitlyn A. Brooks, Christopher G. Gidley, Olivia Grimley, Catherine Wang, Shirin Jivani, Dianna Roberts, Aung Naing, Jack Phan, Katherine Hutcheson, Xin Wang, Paul W. Gidley, Marc‐Elie Nader   +11 more
wiley   +1 more source

Ceruminolith removal and otitis externa in a 2‐year‐old male neutered red kangaroo (Osphranter rufus)

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 2‐year‐old, male, neutered red kangaroo (Osphranter rufus) presented for a 9‐month history of right‐sided otic pruritus, ear droop and otitis externa with suspected ceruminolith formation. At initial presentation, computed tomography of the skull was performed, which revealed a non‐contrast‐enhancing mass effect in the ear canal.
Christina Gentry, Alice Blue‐McLendon
wiley   +1 more source

Neuroauditory Toxicity of Artemisinin Combination Therapies—Have Safety Concerns Been Addressed? [PDF]

, 2014
Although artemisinin-based combination therapies (ACTs) are widely viewed as safe drugs with a wide therapeutic dose range, concerns about neuroauditory safety of artemisinins arose during their development.
Gonzalez, Carmen, Lalloo, David, Mackenzie, Ian, Pace, Cheryl, Ramos Martin, Virginia, Schmutzhard, Joachim, Terlouw, Anja   +6 more
core   +3 more sources

Otoacoustic Emissions for Monitoring Aminoglycoside-Induced Ototoxicity in Children With Cystic Fibrosis [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2002
To investigate whether transient-evoked and distortion-product (DP) otoacoustic emissions (OAEs) are more sensitive than pure-tone audiometry (PTA) in revealing gentamicin-induced ototoxicity in children with cystic fibrosis (CF).Prospective case-control study.Tertiary referral audiologic center in conjunction with an academic pediatric CF unit.The ...
Stavroulaki, P, Vossinakis, IC, Dinopoulou, D, Doudounakis, S, Adamopoulos, G, Apostolopoulos, N   +5 more
openaire   +3 more sources