Results 41 to 50 of about 4,446,831 (170)

Audiological Monitoring of Patients Receiving Ototoxic Drugs [PDF]

Perspectives on Hearing and Hearing Disorders Research and Diagnostics, 2005
Over 200 medications commonly prescribed for the treatment of cancers and some infections can cause inner ear damage, or ototoxicity (ASHA, 2004). Ototoxicity can result in auditory and/or vestibular dysfunction, and the effects can be temporary, but are often permanent.
Dawn Konrad-Martin, Jane S. Gordon, Kelly M. Reavis, Debra J. Wilmington, Wendy J. Helt, Stephen A. Fausti   +5 more
openaire   +1 more source

Medical management of Pseudomonas aeruginosa endocarditis: A case report

Journal of Microbiology and Infectious Diseases, 2023
Background: Pseudomonas aeruginosa is a rare cause of infective endocarditis. There is no standard treatment regimen for the management of infective endocarditis caused by this organism. Pseudomonas aeruginosa produces biofilm on the endocardial surface
Sameer Abdul Samad, Priya T. Nair, Abeed Hussain, Amal Byju, Shafeeq Mattummal, Ravi Arodiyil   +5 more
doaj   +1 more source

Healthcare professionals’ knowledge and practices in managing ototoxicity in children with cancer

South African Journal of Communication Disorders
Background: Platinum-based chemotherapy poses a risk of ototoxic hearing loss, the effects of which can be devastating in paediatrics with cancer. Childhood hearing loss significantly impacts speech and language acquisition, and educational, psychosocial
Kajal Ramnarian, Jessica Paken
doaj   +1 more source

EFFICIENCY OF DISTORTION PRODUCT OTOACOUSTIC EMISSIONS AS A METHOD FOR OTOTOXICITY MONITORING

Journal of hearing science, 2020
Objective: The purpose of this study is to describe hearing and auditory functional changes in patients receiving platinum-based treatments and to estimate the capacity of DPOAE and pure tone audiometry in evaluating ototoxicity as well as evaluating the
G. Sargsyan, V. Bakhshinyan, A. Nazanyan, A. Vardanyan, Naira Hovhannesyan, L. Badalyan, Gnel Ananyan, Arthur Shukuryan   +7 more
semanticscholar   +1 more source

Baseline audiological profiling of South African females with cervical cancer: an important attribute for assessing cisplatin-associated ototoxicity

BMC Women's Health, 2021
Background Cisplatin is a popular antineoplastic agent used to treat cervical cancer in women from low and middle-income countries. Cisplatin treatment is associated with ototoxicity, often resulting in hearing loss.
Jessica Paken, Cyril D. Govender, Mershen Pillay, Birhanu T. Ayele, Vikash Sewram   +4 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Cisplatin-Associated Ototoxicity: A Review for the Health Professional

Journal of Toxicology, 2016
Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life.
Jessica Paken, Cyril D. Govender, Mershen Pillay, Vikash Sewram   +3 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source