Ototoxicity Associated with Antineoplastic Agents in the Pediatric Population: An Evidence-Based Review of Auditory Monitoring Strategies and Contemporary Diagnostic Frameworks—Narrative Review [PDF]
DiagnosticsOtotoxicity represents a clinically significant complication of anticancer therapy in pediatric patients. Cytotoxic agents used in oncology, particularly platinum-based chemotherapy, may induce damage to the auditory and vestibular systems, resulting in ...
Aleksandra Wojno +4 more
doaj +2 more sources
Evaluation of Audiometric Threshold Shift Criteria for Ototoxicity Monitoring [PDF]
Journal of the American Academy of Audiology, 2010 Background:There is disagreement about ototoxicity monitoring methods. Controversy exists about what audiometric threshold shift criteria should be used, which frequencies should be tested, and with what step size. An evaluation of the test performance achieved using various criteria and methods for ototoxicity monitoring may help resolve these issues.
Dawn, Konrad-Martin +6 more
openaire +3 more sources
Healthcare professionals’ knowledge and practices in managing ototoxicity in children with cancer
South African Journal of Communication DisordersBackground: Platinum-based chemotherapy poses a risk of ototoxic hearing loss, the effects of which can be devastating in paediatrics with cancer. Childhood hearing loss significantly impacts speech and language acquisition, and educational, psychosocial
Kajal Ramnarian, Jessica Paken
doaj +3 more sources
Research protocol: Cisplatin-associated ototoxicity amongst patients receiving cancer chemotherapy and the feasibility of an audiological monitoring program [PDF]
BMC Women's Health, 2017 Background Cisplatin is an anti-cancer chemotherapy drug classified as an alkylating agent. It is used for the treatment of a variety of cancers such as cervical, breast, stomach, prostate, bladder and oesophageal, to name a few.
J. Paken, C. D. Govender, V. Sewram
doaj +2 more sources
Contemporary OncologyPlatinum-based compounds used for treating hematologic malignancies can lead to various side effects. One such side effect is ototoxicity, which is characterized by permanent bilateral sensorineural hearing loss or tinnitus.
Aleksandra Janowiak-Majeranowska +3 more
doaj +2 more sources
Establishing a pharmacotherapy induced ototoxicity programme within a service-learning approach
South African Journal of Communication Disorders, 2015 Pharmacotherapy-induced ototoxicity is growing, especially in developing countries such as South Africa. This highlights the importance of ototoxicity monitoring and management of hearing loss.
Natalie Schellack +4 more
doaj +3 more sources
Cisplatin-Associated Ototoxicity: A Review for the Health Professional [PDF]
Journal of Toxicology, 2016 Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life.
Jessica Paken +3 more
doaj +2 more sources
An overview of pharmacotherapy-induced ototoxicity
South African Family Practice, 2013 This article provides an overview of ototoxic medication, as well as different pharmacological and audiological monitoring strategies. Although ototoxic medications play an important role in modern medicine, they also have the capacity to do great harm ...
Natalie Schellack, Alida Naude
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Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa [PDF]
Frontiers in NeurologyBackgroundAminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity.
Adebolajo A. Adeyemo +6 more
doaj +2 more sources
Applying U.S. national guidelines for ototoxicity monitoring in adult patients: perspectives on patient populations, service gaps, barriers and solutions [PDF]
International Journal of Audiology, 2018 Dawn Konrad-Martin +2 more
exaly +2 more sources