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Advances in Materials, 2021
The checkpoint inhibitor therapy that blocks programmed death‐1 (PD‐1) and its major ligand PD‐L1 has achieved encouraging clinical efficacy in certain cancers.
Jingmei Pan +6 more
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The checkpoint inhibitor therapy that blocks programmed death‐1 (PD‐1) and its major ligand PD‐L1 has achieved encouraging clinical efficacy in certain cancers.
Jingmei Pan +6 more
semanticscholar +1 more source
Bordetella pertussis and outer membrane vesicles
Pathogens and Global Health, 2022Bordetella pertussis is the causative agent of a respiratory infection called pertussis (whooping cough) that can be fatal in newborns and infants. The pathogen produces a variety of antigenic compounds which alone or simultaneously can damage various host cells.
Çiğdem Yılmaz Çolak +1 more
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Outer Membrane Vesicles: Biogenesis, Functions, and Issues
Microbiology and Molecular Biology Reviews, 2022This review focuses on nonlytic outer membrane vesicles (OMVs), a subtype of bacterial extracellular vesicles (BEVs) produced by Gram-negative organisms focusing on the mechanisms of their biogenesis, cargo, and function. Throughout, we highlight issues concerning the characterization of OMVs and distinguishing them from other types of BEVs.
Rokas Juodeikis, Simon R. Carding
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EcoSal Plus, 2005
Outer membrane vesicles (blebs) are produced by Escherichia coli , Salmonella , and all other gram-negative bacteria both in vitro and in vivo. Most of the research in the field has focused on the properties of vesicles derived from pathogenic bacteria and their interactions with eukaryotic ...
Amanda J, McBroom, Meta J, Kuehn
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Outer membrane vesicles (blebs) are produced by Escherichia coli , Salmonella , and all other gram-negative bacteria both in vitro and in vivo. Most of the research in the field has focused on the properties of vesicles derived from pathogenic bacteria and their interactions with eukaryotic ...
Amanda J, McBroom, Meta J, Kuehn
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Biological activities of outer membrane vesicles
Canadian Journal of Microbiology, 1989Article de synthese sur les vesicules extracellulaires (vesicules de la membrane externe) des bacteries gram negatif avec mise en relief des especes bacteriennes de la cavite buccale: conditions de formation, methodes d'isolement, composition et activites biologiques (capacite de fixation, activite bacteriocine, activites enzymatiques, activite toxique,
D, Mayrand, D, Grenier
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Development of novel nanoantibiotics using an outer membrane vesicle-based drug efflux mechanism.
Journal of Controlled Release, 2019Conventionally used antibiotics are present in low concentrations at the infection site and require multiple administrations to sustain a continuous bactericidal effect, which not only increases their systemic toxicity but also results in bacterial drug ...
Weiwei Huang +8 more
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LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2019Outer membrane vesicles (OMVs) are secreted by Gram-negative bacteria and induce a stronger inflammatory response than pure LPS. After endocytosis of OMVs by macrophages, lipopolysaccharide (LPS) is released from early endosomes to activate its ...
Anja Pfalzgraff +8 more
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Immune modulation by bacterial outer membrane vesicles
Nature Reviews Immunology, 2015Gram-negative bacteria shed extracellular outer membrane vesicles (OMVs) during their normal growth both in vitro and in vivo. OMVs are spherical, bilayered membrane nanostructures that contain many components found within the parent bacterium. Until recently, OMVs were dismissed as a by-product of bacterial growth; however, findings within the past ...
Maria, Kaparakis-Liaskos +1 more
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Neutralization of Neisseria meningitidis outer membrane vesicles
Inflammation Research, 2011We aimed to determine the neutralization of Neisseria meningitidis outer membrane vesicles (blebs) by humoral and cellular elements of whole blood.The interaction of FITC-labeled blebs with monocytes was studied by spectrofluorometry. Blebs are able to induce an oxidative burst in neutrophils, and we evaluated the inhibitory effect of plasma on this ...
András, Vida +7 more
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Bacteria‐Derived Outer‐Membrane Vesicles Hitchhike Neutrophils to Enhance Ischemic Stroke Therapy
Advances in Materials, 2023The treatment of reperfusion injury after ischemic stroke remains unsatisfactory since the blood‐brain barrier (BBB) prevents most neuroprotective agents from entering the brain.
Jingmei Pan +6 more
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