Results 41 to 50 of about 284,749 (288)
Engineering Planar Gram-Negative Outer Membrane Mimics Using Bacterial Outer Membrane Vesicles
Langmuir, 2023 AbstractAntibiotic resistance is a major challenge in modern medicine. The unique double membrane structure of gram-negative bacteria limits the efficacy of many existing antibiotics and adds complexity to antibiotic development by limiting transport of antibiotics to the bacterial cytosol. New methods to mimic this barrier would enable high-throughput
Aarshi N. Singh +4 more
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Advanced Science, 2022 The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding to and invasion of BBB endothelial cells in bacterial ...
Haiyan Chen +10 more
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Outer membrane vesicles as platform vaccine technology [PDF]
Biotechnology Journal, 2015 AbstractOuter membrane vesicles (OMVs) are released spontaneously during growth by many Gram‐negative bacteria. They present a range of surface antigens in a native conformation and have natural properties like immunogenicity, self‐adjuvation and uptake by immune cells which make them attractive for application as vaccines against pathogenic bacteria ...
van der Pol, Leo +2 more
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Journal of Immunology Research, 2019 Acinetobacter baumannii, as a nonfermentation Gram-negative bacterium, mainly cause nosocomial infections in critically ill patients. With the widespread of multidrug-resistant Acinetobacter baumannii, the urgency of developing effective therapy options ...
Wei Cai +9 more
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Production of Outer Membrane Vesicles and Outer Membrane Tubes by Francisella novicida [PDF]
Journal of Bacteriology, 2012 Francisella spp. are highly infectious and virulent bacteria that cause the zoonotic disease tularemia. Knowledge is lacking for the virulence factors expressed by Francisella and how these factors are secreted and delivered to host cells. Gram-negative bacteria constitutively release outer membrane vesicles (OMV), which may function in the delivery of
William D, McCaig +2 more
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Vesicular Nucleo-Cytoplasmic Transport—Herpesviruses as Pioneers in Cell Biology
Viruses, 2016 Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm.
Thomas C. Mettenleiter
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Outer membrane vesicle-mediated serum protection in Aggregatibacter actinomycetemcomitans
Journal of Oral Microbiology, 2020 Aggregatibacter actinomycetemcomitans belongs to the HACEK group of fastidious Gram-negative organisms, a recognized cause of infective endocarditis. A. actinomycetemcomitans is also implicated in periodontitis, with rapid progress in adolescents.
Mark Lindholm +3 more
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Preparation of Outer Membrane Vesicle from Escherichia coli
Bio-Protocol, 2013 Outer membrane vesicles (OMVs) are spherical bilayered phospholipids of 20-200 nm in size produced from all Gram-negative bacteria and Gram-positive bacteria investigated to date.
Oh Kim +8 more
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Vaccines, 2020 The limited protective immunity induced by acellular pertussis vaccines demands development of novel vaccines that induce broader and longer-lived immunity.
René H. M. Raeven +11 more
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PLoS Pathogens, 2017 Outer membrane vesicles are nano-sized microvesicles shed from the outer membrane of Gram-negative bacteria and play important roles in immune priming and disease pathogenesis.
Eloise J O'Donoghue +8 more
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