Results 61 to 70 of about 162,214 (300)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dinoroseobacter shibae Outer Membrane Vesicles Are Enriched for the Chromosome Dimer Resolution Site dif

mSystems, 2021
Outer membrane vesicles (OMVs) are universally produced by prokaryotes and play important roles in symbiotic and pathogenic interactions. They often contain DNA, but a mechanism for its incorporation is lacking. Here, we show that Dinoroseobacter shibae,
Hui Wang, Nicole Beier, Christian Boedeker, Helena Sztajer, Petra Henke, Meina Neumann-Schaal, Johannes Mansky, Manfred Rohde, Jörg Overmann, Jörn Petersen, Frank Klawonn, Martin Kucklick, Susanne Engelmann, Jürgen Tomasch, Irene Wagner-Döbler   +14 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

ATP-dependent phosphatidylcholine translocation in rat liver canalicular plasma membrane vesicles

Journal of Lipid Research, 1996
Phosphatidylcholine (PC) translocation was studied in rat liver canalicular plasma membrane vesicles using a fluorescent PC analogue that permitted the quantitation of asymmetric PC distribution in the outer and inner leaflet of the vesicles.
A T Nies, Z Gatmaitan, I M Arias
doaj   +1 more source

Immunohistochemical detection of macrophage migration inhibitory factor in fetal and adult bovine epididymis: Release by the apocrine secretion mode? [PDF]

, 2006
Originally defined as a lymphokine inhibiting the random migration of macrophages, the macrophage migration inhibitory factor (MIF) is an important mediator of the host response to infection.
Agarwal A., Agrawal Y., Aumuller G., Bacher M., Bacher M., Bernhagen J., Bloom B.R., Bove S.E., Bronson R.A., Calandra T., Calandra T., Calandra T., Calne R.Y., Choufani G., Cooper T.G., Cropp C.S., David J.R., Eickhoff R., Eickhoff R., F. Sinowatz, Frenette G., Frenette G., Frenette G., G. Hoffbauer, G. Jennemann, Goyal H.O., H. Kaltner, H.-J. Gabius, Hoffer A.P., Howards S.S., Hudson J.D., J. Seitz, Kaltner H., Kaunisto K., Kirchhoff C., Kirchhoff C., Kleemann R., Legendre H., M.-P. Schüring, Manin M., Meinertz H., Meinhardt A., Meinhardt A., R. Eickhoff, Rosengren E., Seitz J., Steinhoff M., Sullivan R., Sun H.W., Suzuki M., Wada S., Wada S., Waeber G., Weiser W.Y., Wilhelm B., Zeng F.Y., Zeng F.Y., Zeng F.Y.   +57 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Preparation of Outer Membrane Vesicle from Escherichia coli

Bio-Protocol, 2013
Outer membrane vesicles (OMVs) are spherical bilayered phospholipids of 20-200 nm in size produced from all Gram-negative bacteria and Gram-positive bacteria investigated to date.
Oh Kim, Bok Hong, Kyong-Su Park, Yae Yoon, Seng Choi, Won Lee, Tae-Young Roh, Yoon-Keun Kim, Yong Gho   +8 more
doaj   +1 more source

GMMA from genetically-engineered meningococcus as vaccine for Africa [PDF]

, 2015
Gram-negative bacteria naturally shed outer membrane vesicles (OMVs). Structural changes in bacterial outer membrane lead to GMMA, Generalized Modules for Membrane Antigens: outer membrane vesicles to use as vaccine. They are safe, cheap to produce, and
Marini, Arianna
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Characterization of the Inflammatory Response Evoked by Bacterial Membrane Vesicles in Intestinal Cells Reveals an RIPK2-Dependent Activation by Enterotoxigenic Escherichia coli Vesicles

Microbiology Spectrum, 2023
Although the immunomodulatory potency of bacterial membrane vesicles (MVs) is widely acknowledged, their interactions with host cells and the underlying signaling pathways have not been well studied.
Himadri B. Thapa, Paul Kohl, Franz G. Zingl, Dominik Fleischhacker, Heimo Wolinski, Thomas A. Kufer, Stefan Schild   +6 more
doaj   +1 more source