Results 21 to 30 of about 445,411 (307)
MS: Wip1 suppresses angiogenesis through the STAT3-VEGF signalling pathway in serous ovarian cancer
Journal of Ovarian Research, 2022 Multifaceted functions of the so-called “oncogene” Wip1 have been reported in a previous study, while its actual role remains to be explored in serous ovarian cancer (SOC).
Sheng Yin +3 more
doaj +1 more source
Generation of endogenously tagged E-cadherin cells using gene editing via non-homologous end joining
STAR Protocols, 2023 Summary: We provide a protocol using non-homologous end joining to integrate an oligonucleotide sequence of a fluorescence protein at the CDH1 locus encoding for the epithelial glycoprotein E-cadherin.
Natalie Rimmer +4 more
doaj +1 more source
Ovarian cancer screening [PDF]
Cancer, 1991 Ovarian cancer will kill more women this year than cancer of the uterine corpus and cervix combined. Outcome is stage dependent. At stage IV, the five year survival rate is about 4.5%, but at stage I it may be well over 90%. Overall, regardless of stage, about 30% of women with ovarian cancer will be alive five years after its diagnosis.
T H, Bourne, K, Reynolds, S, Campbell
openaire +5 more sources
Nature Communications, 2019 OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute ...
James R. Birtley +17 more
doaj +1 more source
Epithelial ovarian cancer [PDF]
The Lancet, 2019 Epithelial ovarian cancer generally presents at an advanced stage and is the most common cause of gynaecological cancer death. Treatment requires expert multidisciplinary care. Population-based screening has been ineffective, but new approaches for early diagnosis and prevention that leverage molecular genomics are in development.
S, Lheureux +3 more
openaire +3 more sources
Whole Tumor Antigen Vaccines: Where Are We?
Vaccines, 2015 With its vast amount of uncharacterized and characterized T cell epitopes available for activating CD4+ T helper and CD8+ cytotoxic lymphocytes simultaneously, whole tumor antigen represents an attractive alternative source of antigens as compared to ...
Cheryl Lai-Lai Chiang +2 more
doaj +1 more source
Scientific Reports, 2023 Low grade serous ovarian carcinoma (LGSOC) demonstrates unique clinical and molecular features compared to other ovarian cancer types. The relationship between common histological features of LGSOC and molecular events, such as hormone receptor ...
Robert L. Hollis +17 more
doaj +1 more source
Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells
Journal of Hematology & Oncology, 2018 Background Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tumor microenvironments, providing ...
Yali Han +3 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source