Results 21 to 30 of about 755,388 (347)
Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. [PDF]
, 2020 Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers.
Axelrod, Joshua +14 more
core +1 more source
Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis
Journal of Ovarian Research, 2020 Background A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity.
Jeremi Laski +5 more
doaj +1 more source
L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary
Communications Biology, 2022 L1CAM is implicated as an important factor that enables early fallopian tube cancer precursors to seed the ovary by promoting cell survival through extracellular matrix signaling, thereby facilitating ovarian cancer growth.
Kai Doberstein +13 more
doaj +1 more source
BMC Cancer, 2017 Background Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies.
Jessica G. Tong +7 more
doaj +1 more source
Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems
Journal of Ovarian Research, 2023 Epithelial ovarian cancer (EOC) research has become more complex as researchers try to fully understand the metastatic process. Especially as we delve into the concept of tumour dormancy, where cells transition between proliferative and dormant states to
Emily Tomas, Trevor G. Shepherd
doaj +1 more source
HE4 in the differential diagnosis of ovarian masses [PDF]
, 2015 Ovarian masses, a common finding among pre- and post-menopausal women, can be benign or malignant. Ovarian cancer is the leading cause of death from gynecologic malignancy among women living in industrialized countries.
ANASTASI, Emanuela +5 more
core +1 more source
MET nucleotide variations and amplification in advanced ovarian cancer: characteristics and outcomes with c-Met inhibitors. [PDF]
, 2013 PurposeMET alterations including amplifications and nucleotide variations have been associated with resistance to therapy and aggressive clinical behavior.Experimental designThe medical records of patients presenting to the University of Texas MD ...
De Melo Galgiato, Debora +13 more
core +9 more sources
Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model [PDF]
, 2012 Ovarian cancer is the leading cause of cancer related deaths in women. Genetic alterations including overexpression of EGFR play a crucial role in ovarian carcinogenesis.
Joseph Alan Bauer +4 more
core +3 more sources
Acta Oncologica, 1996 This synthesis of the literature on radiotherapy for cancer originating in the ovaries is based on 74 scientific articles, including 12 randomized studies, 18 prospective studies, and 36 retrospective studies. These studies involve 6,140 patients. Treatment for patients at early stages of ovarian cancer (stages I and II) is surgery.
openaire +4 more sources
PLoS Medicine, 2012 BackgroundOnly about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent.
Collaborative Group on Epidemiological Studies of Ovarian Cancer
doaj +1 more source