Results 31 to 40 of about 445,411 (307)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Advancing Research Alongside Patient Partners: Next-Generation Best Practices for Effective Collaboration in Health Research

Current Oncology
Ovarian Cancer Canada’s Patient Partners in Research (PPiR) is a national volunteer-based program that trains and connects individuals with lived ovarian cancer (OC) experience to diverse research opportunities, to maximize the clinical relevance and ...
Ally C. Farrell, Jessica A. Lawson, Ovarian Cancer Canada’s Patient Partners in Research Team, Alison Ross, Alicia A. Tone   +4 more
doaj   +1 more source

Prerequisites to improve surgical cytoreduction in FIGO stage III/IV epithelial ovarian cancer and subsequent clinical ramifications

Journal of Ovarian Research, 2023
Background No residual disease (CC 0) following cytoreductive surgery is pivotal for the prognosis of women with advanced stage epithelial ovarian cancer (EOC).
Diederick de Jong, Amudha Thangavelu, Timothy Broadhead, Inga Chen, Dermot Burke, Richard Hutson, Racheal Johnson, Angelika Kaufmann, Peter Lodge, David Nugent, Aaron Quyn, Georgios Theophilou, Alexandros Laios   +12 more
doaj   +1 more source

Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention

Biomolecules & Biomedicine, 2022
Endometrial cancer is the second gynecological cancer with the highest global incidence. Among many associated risk factors, metabolic syndrome is an important and preventable one.
Alejandra Rocío Pérez-Martín, Denisse Castro-Eguiluz , Lucely Cetina-Pérez, Yadira Velasco-Torres, Antonio Bahena-González, Edgar Montes-Servín, Ernesto González-Ibarra, Raquel Espinosa-Romero, Dolores Gallardo-Rincón   +8 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities

Cells
Cancer cell spheroids autonomously form in the ascites fluid and are considered a conduit for epithelial ovarian cancer metastasis within the peritoneal cavity. Spheroids are homotypic, avascular 3D structures that acquire resistance to anoikis to remain
Bart Kolendowski, Sylvia Cheng, Yudith Ramos Valdes, Trevor G. Shepherd, Gabriel E. DiMattia   +4 more
doaj   +1 more source

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

Journal of Hematology & Oncology, 2016
Background The poor prognosis and the limited efficacy of targeted therapy in patients with triple-negative breast cancer (TNBC) have raised the need for alternative therapies.
De-Gang Song, Qunrui Ye, Mathilde Poussin, Jessica A. Chacon, Mariangela Figini, Daniel J. Powell   +5 more
doaj   +1 more source

LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma

Scientific Reports, 2023
Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC).
Sho Sato, Michael Gillette, Pamela R. de Santiago, Eric Kuhn, Michael Burgess, Kristen Doucette, Yi Feng, Carlos Mendez-Dorantes, Paul J. Ippoliti, Sara Hobday, Marilyn A. Mitchell, Kai Doberstein, Stefan M. Gysler, Michelle S. Hirsch, Lauren Schwartz, Michael J. Birrer, Steven J. Skates, Kathleen H. Burns, Steven A. Carr, Ronny Drapkin   +19 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo

Scientific Reports
Epithelial ovarian cancer (EOC) metastasizes predominantly through multicellular aggregates known as spheroids, which disseminate within the peritoneal cavity and initiate secondary disease upon reattachment at distant sites.
Matthew J. Borrelli, Adrian Buensuceso, Yudith Ramos Valdes, Tiffany P.A. Johnston, Jacob Haagsma, Trevor G. Shepherd   +5 more
doaj   +1 more source