Results 41 to 50 of about 5,108,464 (344)

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers [PDF]

open access: yes, 2016
Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer.
Agnarsson, Bjarni A.   +252 more
core   +1 more source

Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer.

open access: yesNew England Journal of Medicine, 2019
BACKGROUND Olaparib has shown significant clinical benefit as maintenance therapy in women with newly diagnosed advanced ovarian cancer with a BRCA mutation.
I. Ray-Coquard   +29 more
semanticscholar   +1 more source

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

open access: yesNucleic Acids Research, 2020
N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis.
Tao Liu   +17 more
semanticscholar   +1 more source

The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. [PDF]

open access: yes, 2011
The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death.
Anish Bali   +6 more
core   +5 more sources

Treatment of epithelial ovarian cancer

open access: yesBritish medical journal, 2020
Ovarian cancer is the third most common gynecologic malignancy worldwide but accounts for the highest mortality rate among these cancers. A stepwise approach to assessment, diagnosis, and treatment is vital to appropriate management of this disease ...
L. Kuroki, S. Guntupalli
semanticscholar   +1 more source

Generation of endogenously tagged E-cadherin cells using gene editing via non-homologous end joining

open access: yesSTAR Protocols, 2023
Summary: We provide a protocol using non-homologous end joining to integrate an oligonucleotide sequence of a fluorescence protein at the CDH1 locus encoding for the epithelial glycoprotein E-cadherin.
Natalie Rimmer   +4 more
doaj   +1 more source

In Vitro Chemosensitivity Using the Histoculture Drug Response Assay in Human Epithelial Ovarian Cancer [PDF]

open access: yes, 2012
The choice of chemotherapeutic drugs to treat patients with epithelial ovarian cancer has not depended on individual patient characteristics. We have investigated the correlation between in vitro chemosensitivity, as determined by the histoculture drug ...
Kim, Dae-Yeon   +6 more
core   +1 more source

Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy [PDF]

open access: yes, 2009
Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer.
B Stordal   +7 more
core   +2 more sources

CA125 and Ovarian Cancer: A Comprehensive Review

open access: yesCancers, 2020
Simple Summary CA125 has been the most promising biomarker for screening ovarian cancer; however, it still does not have an acceptable accuracy in population-based screening for ovarian cancer.
Parsa Charkhchi   +5 more
semanticscholar   +1 more source

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]

open access: yes, 2016
The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J.   +3 more
core   +1 more source

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