Results 71 to 80 of about 5,337,795 (240)

Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance

Cancer Research, 2020
Ovarian cancer metastatic progression can be restricted by targeting a critical regulator of lipid responses, FABP4. Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic changes initiated by this interaction are ...
A. Mukherjee, Chun-Yi Chiang, H. Daifotis, K. Nieman, Johannes F. Fahrmann, R. Lastra, Iris L. Romero, O. Fiehn, E. Lengyel   +8 more
semanticscholar   +1 more source

MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. [PDF]

, 2015
Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic.
Amiji, Mansoor M, Choy, Edwin, Duan, Zhenfeng, Hornicek, Francis J, Iyer, Arun K, Singh, Amit, Yang, Xiaoqian   +6 more
core   +1 more source

Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C

Cells, 2020
Ovarian clear cell carcinoma (OCCC) is a rare subtype of gynecological cancer for which well-characterized and authenticated model systems are scarce. We provide an extensive characterization of ‘105C’, a cell line generated from an adenocarcinoma of the
Bart Kolendowski, Yudith Ramos Valdes, Hal Hirte, Hiroaki Itamochi, Wonjae Lee, Mark Carey, Trevor G. Shepherd, Gabriel E. DiMattia   +7 more
doaj   +1 more source

Deciphering the Importance of Glycosphingolipids on Cellular and Molecular Mechanisms Associated with Epithelial-to-Mesenchymal Transition in Cancer

Biomolecules, 2021
Every living cell is covered with a dense and complex layer of glycans on the cell surface, which have important functions in the interaction between cells and their environment.
Cécile Cumin, Yen-Lin Huang, Arun Everest-Dass, Francis Jacob   +3 more
doaj   +1 more source

Niraparib in ovarian cancer. results to date and clinical potential [PDF]

, 2017
Ovarian cancer is the first cause of death from gynaecological malignancy. Germline mutation in BRCA1 and 2, two genes involved in the mechanisms of reparation of DNA damage, are showed to be related with the incidence of breast and ovarian cancer, both ...
Benedetti Panici, Pierluigi, Caruso, Davide, Papa, Anselmo, Tomao, Federica, Tomao, Silverio, Vici, Patrizia   +5 more
core   +1 more source

Ovarian cancer in the world: epidemiology and risk factors

International Journal of Women's Health, 2019
Aim: Ovarian cancer is one of the most common gynecologic cancers that has the highest mortality rate. Considering the fact that knowledge on the incidence, mortality of ovarian cancer, as well as its risk factors is necessary for planning and preventing
Z. Momenimovahed, A. Tiznobaik, S. Taheri, H. Salehiniya   +3 more
semanticscholar   +1 more source

BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases

Journal of Ovarian Research, 2020
It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes.
M. Suszyńska, M. Ratajska, P. Kozłowski   +2 more
semanticscholar   +1 more source

Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis

Cells
Epithelial ovarian cancer (EOC) exhibits a unique mode of metastasis, involving spheroid formation in the peritoneum. Our research on EOC spheroid cell biology has provided valuable insights into the signaling plasticity associated with metastasis.
Emily J. Tomas, Yudith Ramos Valdes, Jennifer Davis, Bart Kolendowski, Adrian Buensuceso, Gabriel E. DiMattia, Trevor G. Shepherd   +6 more
doaj   +1 more source

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

Journal of Hematology & Oncology, 2016
Background The poor prognosis and the limited efficacy of targeted therapy in patients with triple-negative breast cancer (TNBC) have raised the need for alternative therapies.
De-Gang Song, Qunrui Ye, Mathilde Poussin, Jessica A. Chacon, Mariangela Figini, Daniel J. Powell   +5 more
doaj   +1 more source

Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients. [PDF]

, 2017
PurposeMany women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing.
Adams, Sophie B, Chan, Salina, Crawford, Beth, Gil, Elad, Leitner, Ofri, Ryan, Lauren, Sittler, Taylor, van 't Veer, Laura, van den Akker, Jeroen   +8 more
core   +1 more source