Results 41 to 50 of about 272,037 (262)

Promising Remission with Reduced Bevacizumab and Pembrolizumab Dosage in a Patient with AT-rich Interaction Domain 1A Mutated Ovarian Clear-cell Carcinoma Refractory to Chemotherapy

Journal of Cancer Research and Practice
Patients with ovarian clear-cell carcinoma have limited treatment choices, because they are resistant to the standard chemotherapeutic agents used in ovarian cancer. The phase II KEYNOTE-100 trial revealed that pembrolizumab monotherapy demonstrated a 15.
Cheng-Wei Huang, Ruo-Han Tseng
doaj   +1 more source

Clear-Cell Carcinoma of the Ovary with Bilateral Breast Metastases

Case Reports in Oncological Medicine, 2019
Ovarian clear-cell carcinoma is an uncommon subtype of epithelial ovarian carcinoma. It carries a generally poor prognosis because of its resistance to standard treatment and metastatic spread to vital organs.
Yehuda Galili, Meghan Lytle, Jonathan Bartolomei, Kataria Amandeep, Nichole Allen, S. J. Carlan, Mario Madruga   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

Journal of Ovarian Research, 2017
Background This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma.
Yu Zhao, Shu Wang, Yi-Min Qu, Yu-Ting Ji, Keng Shen, Jing He Lang   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

“The Long Road to a Rare Destination”: Ovarian Serous Carcinoma With Late Thymic Metastasis 25 Years After Diagnosis

Clinical Case Reports
We report a rare case of thymic metastasis of ovarian serous carcinoma. A 72‐year‐old woman who had undergone surgery for low‐grade serous carcinoma of the ovary and had been free of disease for 25 years was noted to have rising CA‐125 levels.
Nicole Fye, Nicholas D'Alonzo, Pauline H. Go, Sanica Bhele   +3 more
doaj   +1 more source

High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers. [PDF]

PLoS ONE, 2013
OBJECTIVES:To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
Zhenhua Hu, Jian Gao, Danye Zhang, Qing Liu, Limei Yan, Lili Gao, Juanjuan Liu, Dawo Liu, Shulan Zhang, Bei Lin   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The role of reactive oxygen species metabolism-related genes in mediating cisplatin resistance in ovarian clear cell carcinoma

Journal of the Pakistan Medical Association
Cisplatin resistance in ovarian cancer, particularly in ovarian clear cell carcinoma, involves intricate mechanisms related to oxidative stress, deoxyribonucleic acid repair, and cell cycle.
Wen Deng, Jingwu Wu, Xiaohui Wang, Na Zhao, Kai Hu, Minglei Fu   +5 more
doaj   +1 more source

KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis

Tumor Biology, 2017
This study aimed to determine whether serum karyopherin alpha 2 levels can be used as a diagnostic biomarker for epithelial ovarian carcinoma. Karyopherin alpha 2 protein was detected by enzyme-linked immunosorbent assay in serum samples from 162 ...
Long Huang, Yun Zhou, Xin-Ping Cao, Jia-Xin Lin, Lan Zhang, Shu-Ting Huang, Min Zheng   +6 more
doaj   +1 more source