HiST, a multiscale deep learning framework, reconstructs spatially resolved gene expression profiles directly from histological images. It accurately identifies tumor regions, captures intratumoral heterogeneity, and predicts patient prognosis and immunotherapy response.
Wei Li +8 more
wiley +1 more source
The DEAD-box RNA helicase eIF4A is a crucial factor for stem-cell activity and reproduction of the parasite <i>Schistosoma mansoni</i>. [PDF]
Welsch S +6 more
europepmc +1 more source
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang +10 more
wiley +1 more source
GPER1 activation regulates renal purinergic P2Y<sub>2</sub> receptor natriuretic pathway. [PDF]
Kulthinee S +3 more
europepmc +1 more source
HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong +14 more
wiley +1 more source
Computed Tomography Angiography-Assisted Ovarian Vein Sampling for Diagnosing an Androgen-Producing Leydig Cell Tumor: A Case Report. [PDF]
Tomotsune K +11 more
europepmc +1 more source
A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo +12 more
wiley +1 more source
Morphological and histochemical examination of male and female gonads in Homarus gammarus (L. 1758)
Erkan Melike, Ayun Yasemin
doaj +1 more source
Modified Transabdominal Oocyte Retrieval Guided by Vaginal Ultrasound Probe: A Case Report and Literature Review. [PDF]
Yang G +5 more
europepmc +1 more source

