Results 251 to 260 of about 623,592 (315)

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Intraovarian injection of securinine stimulates the growth of small ovarian follicles by reducing stromal suppression. [PDF]

Nat Commun
Zhao Y, Liu D, Lin Z, Deng S, Zhao X, Sun Y, Zhang Y, Zhang Q, Gu J, Xiao Y, Wang T, Lu H, Zhao J, Chan KKL, Li Y, Yeung WSB, Liu K.   +16 more
europepmc   +1 more source

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source

Queen Loss Remodels Brain Dopamine and Hormonal Pathways During Worker Ovary Activation in <i>Apis mellifera</i>. [PDF]

Insects
Zhao M, Wu J, Kang W, Wei Q, Xu S, Guo H, Han B.   +6 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Analysis of key regulatory genes for egg-laying performance in inner Mongolia bian chicken and prairie green chicken. [PDF]

Poult Sci
Chen Y, Ha D, Wu S, Zhang J, Li G, Zhang Y, Zhao X, Song K, Han Z, Du C.   +9 more
europepmc   +1 more source

Total Abdominal Hysterectomy in a Young Woman With Refractory Abnormal Uterine Bleeding of Multifactorial Etiology: A Case Report of an Incidental Hemorrhagic Ovarian Cyst in a Single Ovary. [PDF]

Cureus
de La Cruz TL, Mateus KP, Tawil AJ, Portilla RF, Valladares C.   +4 more
europepmc   +1 more source

A Narrative Review of Recent Insights on Nerve Growth Factor Signaling in Physiological and Pathological Ovarian Processes in Mammals. [PDF]

Biomolecules
Aloisi M, Rossi G, Cecconi S.
europepmc   +1 more source

Evaluation and management of worsening virilization in a postmenopausal woman diagnosed with PCOS. [PDF]

J Endocr Soc
Osborne MF, Horton WB, Pesch AJ, Santen RJ.   +3 more
europepmc   +1 more source

IMPLANTATION OF AN OVARY

Annals of Surgery, 1925
openaire   +3 more sources