Results 241 to 250 of about 618,347 (307)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Correction for Ganguly et al., The Nemp1-Nesprin complex mediates cellular responses to matrix mechanics. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Scaffold-based biomaterials in ovarian tissue engineering. [PDF]

RSC Adv
Di Berardino C, Liverani L, Boccaccini AR, Rojo-Fleming CC, Sacchetti G, Peserico A, Camerano Spelta Rapini C, Capacchietti G, Barboni B.   +8 more
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Unilateral vulvar hematoma after laparoscopic detorsion of the ipsilateral ovary following oocyte retrieval for IVF: A case report and review of anatomy and surgical planning. [PDF]

Case Rep Womens Health
Linfield R, Lipkin P, Reich J, Jain N, Blakemore J.   +4 more
europepmc   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Integrated network toxicology suggests potential mechanisms involving environmental flame retardant TDCPP in ovarian cancer progression via "liver-to-ovary crosstalk." [PDF]

Environ Health
Shi Z, Li Z, Li Y, Yang F.
europepmc   +1 more source

Mouse germline cysts contain a fusome-like structure that mediates oocyte development. [PDF]

Elife
Pathak M, Spradling AC.
europepmc   +1 more source

Diagnostic Challenges and Surgical Management of Ovarian Hydatid Cyst: A Case Report From an Endemic Region and Literature Review. [PDF]

Clin Case Rep
Asadi Kohbad F, Akbari R, Forouzin M, Nili F, Asadi L, Ghaemi M.   +5 more
europepmc   +1 more source

Primary Ovarian Leiomyoma in a 2-year-old Child: Youngest Worldwide and First Report from India with Review of Literature.

J Indian Assoc Pediatr Surg
Ahmad MF, Nahid E, Bano S, Mallya V, Batra R, Goswami D, Kumar P, Ratan SK, Gupta A, Kumar J.   +9 more
europepmc   +1 more source