Results 241 to 250 of about 1,435,507 (315)

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

KLF9 Aggravates Doxorubicin-Induced Cardiotoxicity by Regulating the ROS/p53 Signalling Pathway. [PDF]

Cardiovasc Toxicol
Peng J, Wang J, Feng H, Zhou B, Zhou H, Li F.   +5 more
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

GLIS3 drives epithelial-mesenchymal transition and cancer stem-like traits in stomach adenocarcinoma via TGFBR3-Hedgehog signaling. [PDF]

Front Oncol
Xiao Q, Deng H, Li J, Zheng Y, Zhang Y.
europepmc   +1 more source

HER2 Overexpression in Invasive Breast Carcinoma in the Democratic Republic of Congo and its Association with Selected Clinicopathological Characteristics. [PDF]

Breast Cancer (Dove Med Press)
Ilunga Nday G, Ilunga Banza M, Umpungu AN, Kabamba Nzaji M, Moyambe JNT.   +4 more
europepmc   +1 more source

Lipid droplet associated protein HILPDA promotes hypoxia-induced ferroptosis by driving LPCAT3-mediated polyunsaturated phospholipids enrichment. [PDF]

PLoS One
Song Z, Li W, Zeng J, Wang X, Wang D, Liao X.   +5 more
europepmc   +1 more source

DKK1 Suppresses Hippo Signaling via PIP₃-OGT-LRP6 <i>O</i>-GlcNAcylation in Hepatocellular Carcinoma. [PDF]

Cancer Commun (Lond)
Lee U, Eun JW, Kim T, Shim H, Choi Y, Jung H, Mo J, Kim SS, Baek GO, Yoon MG, Lee H, Lee W, Kim W, Kim J, Yi EC, Kim SU, Cheong JY, Jho EH.   +17 more
europepmc   +1 more source

PAFAH2 deficiency drives sepsis-induced vascular leakage by promoting ECHS1-mediated suppression of protein crotonylation and mitochondrial dysfunction. [PDF]

Inflamm Regen
Yang R, Zhang Y, Wu Y, Li W, Zhang Y, Bao D, Ran X, Zhang J, Ren Y, She H, Zuo D, Wang Y, Hu Y, Mao Q.   +13 more
europepmc   +1 more source

Super-enhancer-driven KIAA1522 upregulation suppresses ferroptosis in hepatocellular carcinoma. [PDF]

Clin Transl Med
Li X, Hu S, Shi H, Bian P, Wang Z, Sun J.   +5 more
europepmc   +1 more source