Results 251 to 260 of about 1,435,507 (315)

EXPRESSION OF CONCERN: Overexpression of TNKS1BP1 in Lung Cancers and Its Involvement in Homologous Recombination Pathway of DNA Double-Strand Breaks. [PDF]

Cancer Med
europepmc   +1 more source

Overexpression of sucrose-phosphate synthase in wheat

, 1999
Foyer, C. H., West, J. M., Sparks, C. A., Quick, W. P., Castleden, C. K.   +4 more
core  

HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials

Journal of Pathology, 2016
HER2 overexpression/amplification is linked to trastuzumab response in breast/gastric cancers. One suggested anti‐EGFR resistance mechanism in colorectal cancer (CRC) is aberrant MEK–AKT pathway activation through HER2 up‐regulation.
Susan D Richman, Philip Chambers, Morag Taylor   +2 more
exaly   +2 more sources

POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma

Cancers, 2019
DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs).
Kazuya Shinmura, Hisami Kato, Katsuhiro Yoshimura   +2 more
exaly   +2 more sources

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FOXG1 is overexpressed in hepatoblastoma

Human Pathology, 2007
Bacterial artificial chromosome array comparative genomic hybridization analysis of hepatoblastomas reveals a deletion in the 14q12 locus in 12 of 16 cases. A high frequency of copy gain is seen on chromosomes 1q, 2, 5p, 8, and 20. Frequent deletions are also seen at 6q, 17q, and 1p with less frequent gains on 4p, 6p, and 19p.
Adekunle Michael, Adesina, Yummy, Nguyen, Preethi, Guanaratne, Joseph, Pulliam, Dolores, Lopez-Terrada, Judy, Margolin, Milton, Finegold   +6 more
openaire   +2 more sources

The transience of transient overexpression

Nature Methods, 2013
Much of what is known about mammalian cell regulation has been achieved with the aid of transiently transfected cells. However, overexpression can violate balanced gene dosage, affecting protein folding, complex assembly and downstream regulation. To avoid these problems, genome engineering technologies now enable the generation of stable cell lines ...
Gibson, Toby J, Seiler, Markus, Veitia, Reiner A   +2 more
openaire   +3 more sources

Cad Overexpression in Mammalian Cells

Clinical Biochemistry, 1997
Hamster CAD is a multifunctional protein which catalyzes the first three enzymatic steps of de novo pyrimidine biosynthesis.1'2 The major catalytic domains of CAD are car-bamyl phosphate synthetase (CPSase) (EC 6.3.5.5), dihydroorotase (DHOase) (EC 3.5.2.3), and aspartate transcarbamylase (ATCase) (EC 2.1.3.2). The first enzyme of the pathway, carbamyl
Y, Qiu, J N, Davidson
openaire   +2 more sources