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The consequence of PRELP overexpression on skin

Matrix Biology, 2007
PRELP is a member of the small leucine-rich repeat proteoglycan family that is abundantly expressed in many cartilages compared to other connective tissues. To study the consequence of PRELP overexpression in tissues where it is normally expressed at low abundance, transgenic mice were generated in which the human PRELP transgene was placed under ...
J, Grover +4 more
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N-MYC overexpression and neuroblastomas

Trends in Pharmacological Sciences, 2002
In the advanced stages of human neuroblastomas, amplification of the N-MYC oncogene is a frequent event and correlates with poor prognosis and enhanced neovascularization. N-MYC amplification results in high N-MYC protein levels that can perturb the finely tuned interplay of N-MYC and MAX and could eventually induce abnormal expression patterns of ...
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The Cellular Effects of E2F Overexpression

1996
The product of the retinoblastoma tumor-suppressor gene (RB) is a ubiquitously expressed, 105-kDa nuclear phosphoprotein (pRB). The pRB protein negatively regulates the cellular G1/S phase transition, and it is at this point in the cell cycle that it is thought to play its role as a tumor suppressor. The growth-inhibitory effects of pRB are exerted, at
P D, Adams, W G, Kaelin
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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.