Results 51 to 60 of about 6,489,983 (282)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The economic performance of the New England states in 2004: an overview [PDF]

The year 2004 marked the beginning of New England’s economic turnaround. After three consecutive years of job losses — not to mention 86 years of World Series famine — the region emerged victorious.
Brad Hershbein, Eamon Aghdasi, Nelson Gerew, Nick Turner, Teferi Mergo, Tom DeCoff   +5 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Growing... but slowing? : an overview of New England's economic performance in 2006 [PDF]

New England’s economic performance was somewhat mixed during 2006. On one hand, all six states added jobs over the course of the year, and the region’s unemployment rate remained steady. The region as a whole picked up jobs in nearly all major industries.
Erin Langlois, Jessamyn Fleming, Joanna Helou, Matthew Nagowski, Nelson Gerew, Tom DeCoff   +5 more
core  

RHIC physics overview

, 2010
The results from data taken during the last several years at the Relativistic Heavy-Ion Collider (RHIC) will be reviewed in the paper. Several selected topics that further our understanding of constituent quark scaling, jet quenching and color screening ...
A. Adare, A. Adare, A. Adare, A. Adil, A. Barducci, A. Barducci, A. D. Frawley, A. H. Mueller, A. H. Mueller, A. Kovner, A. Stephanov, B. B. Back, B. B. Back, B. B. Back, B. B. Back, B. Biritz, B. Bonner, B. I. Abelev, B. I. Abelev, B. I. Abelev, B. I. Abelev, B. I. Abelev, B. I. Abelev, B. I. Abelev, B. I. Abelev, B. Mohanty, C. Adler, C. Perkins, D. E. Kharzeev, D. Kharzeev, D. Molnr, E. Iancu, E. Schnedermann, F. Karsch, G. David, H. Liu, H. Liu, H. Satz, H. V. Hess, I. Arsene, I. Arsene, I. Arsene, I. G. Bearden, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. Adams, J. C. Collins, J. C. Collins, J. Chen, J. Harris, J. Putschke, K. Adcox, K. Adcox, K. Adcox, K. Fukushima, L. Cormell, L. D. McLerran, L. Grandchamp, L. Ruan, Li-juan Ruan, M. Adamczyk, M. Asakawa, M. Asakawa, M. Asakawa, M. C. Abreu, M. Cheng, M. Cheng, M. I. Gorentein, M. Leitch, M. Ploskon, M. Shao, N. Armesto, N. Xu, P. Artoisenet, P. Braun-Munzinger, P. Braun-Munzinger, P. Braun-Munzinger, P. Braun-Munzinger, P. Huovinen, R. C. Hwa, R. J. Fries, R. L. Thews, R. Rapp, R. Vogt, S. Afanasiev, S. Albino, S. Datta, S. Ejiri, S. Huang, S. Huang, S. Kleinfelder, S. S. Adler, S. S. Adler, S. S. Adler, S. S. Adler, S. S. Adler, S. S. Adler, S. S. Adler, S. Sapeta, S. Shi, S. Wicks, T. Gunji, T. Matsui, T. Renk, T. Renk, T. Roser, V. Greco, W. Liu, W. Liu, X. Dong, X. N. Wang, X. N. Wang, X. Zhao, Y. Aoki, Y. Aoki, Y. L. Dokshitzer, Y. Xu, Z. B. Tang   +127 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

In the shadows of the national recovery: an overview of New England's economic performance in 2005 [PDF]

Annual review of the economic performance of the New England states.Economic conditions - New ...
Brad Hershbein, Jessamyn Fleming, Matthew Nagowski, Nelson Gerew, Tom DeCoff   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Sexual Assault Study: Overview [PDF]

, 2004
Poster originally presented to the Anchorage Police Department and the 2004 Alaska Summit on Violence Against Women.Anchorage Community Indicators is a public education project of the Justice Center aimed at providing information about various aspects of
Langworthy, Robert H., Rosay, André B.
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source