Results 101 to 110 of about 146,710 (261)

Systematic reviews: a brief overview

Jornal Brasileiro de Pneumologia, 2020
Natalia Causada Calo, Juliana Carvalho Ferreira, Cecilia Maria Patino   +2 more
openaire   +3 more sources

Ginger for health care: An overview of systematic reviews

Complementary Therapies in Medicine, 2019
To summarize the evidence from systematic reviews (SRs) and meta-analyses that evaluated the efficacy of ginger in treating any conditions and critically assess the quality of these evidence.A systematic search of the literature was conducted from inception until February 28, 2019 using the PubMed, EMBASE, Web of science, Cochrane library, and four ...
Huijuan, Li, Yanan, Liu, Dan, Luo, Yuzhen, Ma, Jie, Zhang, Meixuan, Li, Liang, Yao, Xiue, Shi, Xingrong, Liu, Kehu, Yang   +9 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Diagnostic accuracy of 18F Prostate Specific Membrane Antigen (PSMA) PET-CT radiotracers in staging and restaging of high-risk prostate cancer patients and patients with biochemical recurrence: protocol for an overview of reviews [version 2; peer review: 2 approved]

HRB Open Research
Background Correct staging and risk stratification is essential in ensuring prostate cancer patients are offered the most appropriate treatment. Interest has been growing in the use of radiotracers targeting prostate specific membrane antigen (PSMA ...
Susan Ahern, Kieran A. Walsh, Lydia O'Sullivan, Andrew Dullea, Máirín Ryan, Kirsty O'Brien, Patricia Harrington, Susan M. Smith, Marie Carrigan, Maeve McGarry   +9 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Overviews of systematic reviews: great promise, greater challenge

Systematic Reviews, 2017
The proliferation of systematic reviews and escalating demand from policy makers has driven a newer form of evidence synthesis—overviews of systematic reviews.
Joanne E. McKenzie, Sue E. Brennan
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Comparative efficacy and safety of intravenous versus nebulized magnesium sulfate for acute asthma exacerbations: an overview of systematic reviews and meta-analyses

Frontiers in Medicine
ObjectiveThis study aimed to conduct an umbrella review comparing intravenous versus nebulized magnesium sulfate for acute asthma exacerbations, providing evidence to guide route selection and clinical decision-making.MethodsWe systematically searched ...
Yongji Wang, Yongji Wang, Zhuang Wang, Shengtao Cui, Lijie Hou, Bing Tian, Xiaofei Xie, Yongfu Song, Shulei Liu, Ying Wang   +9 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source