Results 111 to 120 of about 935,224 (290)

Dressings for treating foot ulcers in people with diabetes: an overview of systematic reviews [PDF]

, 2015
Background: Foot ulcers in people with diabetes mellitus are a common and serious global health issue. Dressings form a key part of ulcer treatment, with clinicians and patients having many different types to choose from.
Abbott, Ahroni, Apelqvist, Apelqvist, Ashton, Atkins, Bergin, Blackman, Boateng, Bradley, Braun, Brimson, Cardinal, D'Hemecourt, Donaghue, Dorresteijn, Dumville, Dumville, Dumville, Dumville, Dumville, Eddy, Edmonds, Edwards, Fiskin, Foster, Game, Gils, Greer, Heyer, Hinchliffe, Hinchliffe, Holmes, Ince, Jadad, Jeffcoate, Jensen, Jones, Jude, Jull, Karthikesalingam, Kumar, Lalau, Lewis, Margolis, Mason, Mason, Meara, Morris, Nabuurs-Franssen, Nelson, Oyibo, Pecoraro, Piaggesi, Pound, Price, Reiber, Reiber, Ribu, Roberts, Schaper, Shea, Singh, Steed, Storm-Versloot, Tian, Vandamme, Veves, Voigt, Wagner, Wang, Ware, Wild, Winter, Wrobel   +74 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Population-level interventions to reduce alcohol-related harm: an overview of systematic reviews.

, 2013
OBJECTIVE: To analyse available review-level evidence on the effectiveness of population-level interventions in non-clinical settings to reduce alcohol consumption or related health or social harm.
Lock, Karen, Lorenc, Theo, Martineau, Fred, Petticrew, Mark, Tyner, Elizabeth   +4 more
core   +1 more source

Introductory programming: a systematic literature review [PDF]

, 2018
As computing becomes a mainstream discipline embedded in the school curriculum and acts as an enabler for an increasing range of academic disciplines in higher education, the literature on introductory programming is growing.
Abu Naser Samy S., Agarwal Achla, Ahmed, Ahren T. C., Al-Jarrah Ahmad, Alammary Ali, Annamalai Subashini, Ayub Mewati, Badri Suzan, Bai Yu, Baird Bridget, Bandura Albert, Barlow-Jones Glenda, Bayliss Jessica D., Ben-Ari Mordechai, Bennedsen Jens, Bennett Chris, Berglund Anders, Berland Matthew, Briggs Tom, Bumbacher Engin, Burch Carl, Carbonaro Antonella, Carbone Angela, Cardell-Oliver Rachel, Chad Lane H, Char Bruce, Charalampos Spyropoulos, Charles Therese, Chinn Donald, Chinn Donald, Corney Malcolm, Coull Natalie J, Crawford Stewart, Cruz Gilbert, de Raadt Michael, de Raadt Michael, de Raadt Michael, de Raadt Michael, de Raadt Michael, Devey Adrian, Dickson Paul E., Dillon Edward, Doherty Liam, Durrheim Mark S., D’Souza Daryl, Eagly Alice H, Edgcomb Alex, Edwards Stephen H., Falkner Katrina, Firmalo Fabic Geela Venise, Fonseca Fred, Fürst Luka, Garner Stuart, Goadrich Mark, Gonzalez Gracielo, Gudmundsen Dee, Haghighi Pari Delir, Hare Brian K, Heliotis James, Hooshyar Danial, Hovemeyer David, Hu Minjie, Hu Minjie, Hu Yun-Jen, Huang Chenn-Jung, Jacqueline, Jayal Ambikesh, Jurado Francisco, Kanaparan Geetha, Kasto Nadia, Kiran L., Kirby Stephen, Kitchenham Barbara, Kouznetsova Svetlana, Kölling Michael, LeJeune Noel, Leska Chuck, Lipman Derrell, Lister Raymond, Lister Raymond, Lister Raymond, Lopez Mike, Lulis Evelyn, Luoma Harri, Major L., McKeown Jim, McWhorter William Isaac, Medley M. Dee, Mentis Alexander, Menyhárt László, Mullins Paul, Munson Jonathan P., Muntha Surya, Murphy Laurie, Neto Vicente Lustosa, Nguyen Thuy-Linh, Okada Ken, Orehovački Tihomir, Orehovački Tihomir, Palmer James Dean, Park Myung Ah, Parsons Dale, Paul Jody, Peachock Patrick, Pearce Janice L., Pero Štefan, Price Kellie, Quintin, Rajala Teemu, Ramli R.Z., Ray Andrew, Rodrigo Maria Mercedes T, Roels Reinout, Rountree Janet, Russo Mark F., Sanou Loé, Schoeffel Pablo, Schramm Joachim, Shabalina Olga, Sharp Jason H, Sheard Judy, Sheard Judy, Shuhidan Shuhaida, Sindre Guttorm, Skudder Ben, Song Hosung, Sorva Juha, Sung Kelvin, Takemura Yasuhiro, Teague D., Teague Donna, Teague Donna, Teague Donna, Teague Donna, Thompson Errol, Torrey Lisa, Truong Nghi, Vincenti Giovanni, Wang Hong, Watkins Kera Z. B., Weragama Dinesha, Whalley Jacqueline, Whalley Jacqueline, Whalley Jacqueline, Whittall S. J., Whittinghill David, Wiebe E, Wood Krissi, Yoo Jungsoon P, Yusri Nurliana   +150 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluation of AMSTAR to assess the methodological quality of systematic reviews in overviews of reviews of healthcare interventions

BMC Medical Research Methodology, 2017
Background Overviews of reviews (overviews) compile information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making.
Michelle Pollock, Ricardo M. Fernandes, Lisa Hartling   +2 more
doaj   +1 more source

Berberine and health outcomes: an overview of systematic reviews. [PDF]

BMC Complement Med Ther
Berberine is an isoquinoline alkaloid isolated from Chinese herb coptis chinensis and other berberis plants which can be used to treat a wide range of chronic diseases. However, the current research evidence on the therapeutic effects of berberine has not been summarized.
Shi L, Wang W, Jing C, Hu J, Liao X.
europepmc   +4 more sources

Non-pharmacological management interventions for COPD: An overview of Cochrane systematic reviews [PDF]

, 2013
© 2013 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd. This is the protocol for a review and there is no abstract. The objectives are as follows: To a) summarise the evidence, b) identify gaps in the evidence base and c) describe elements
Davidson, PM, Disler, RT, Inglis, SC
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source