Results 211 to 220 of about 259,578 (273)
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Effects of NIX‐mediated mitophagy on ox‐LDL‐induced macrophage pyroptosis in atherosclerosis

Cell Biology International, 2020
Pyroptosis is a form of cell death that is uniquely dependent on caspase‐1. Pyroptosis involved in oxidized low‐density lipoprotein (ox‐LDL)‐induced human macrophage death through the promotion of caspase‐1 activation is important for the formation of ...
Xue Peng   +5 more
semanticscholar   +3 more sources

Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation.

Free Radical Biology & Medicine, 2023
Oxidized low-density lipoprotein (OX-LDL)-induced inflammation and autophagy dysregulation are important events in the progression of atherosclerosis.
Tingting Hao   +9 more
semanticscholar   +1 more source

Electrochemical sensor based on micromotor technology for detection of Ox-LDL in whole blood.

Biosensors & bioelectronics, 2022
Detecting the concentration of oxidized low-density lipoprotein (Ox-LDL) in whole blood is of great significance for monitoring the development of atherosclerosis. In order to simplify the complex processing steps of blood sample before the detection, an
Dan Fang   +6 more
semanticscholar   +1 more source

Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.

Biochemical Pharmacology, 2021
Sirtuin3 (SIRT3) is involved in reactive oxygen species (ROS), cell metabolism, apoptosis and inflammation. However, the exact role of SIRT3 in macrophages during pathophysiological process of atherosclerosis remains unclear.
Yue Ding   +7 more
semanticscholar   +1 more source

Oxidized Low-Density Lipoprotein (ox-LDL) to LDL Ratio (ox-LDL/LDL) and ox-LDL to High-Density Lipoprotein Ratio (ox-LDL/HDL):

Clinical Laboratory, 2016
Oxidized low-density lipoprotein (ox-LDL) plays a principal role in diabetes complications, though ox-LDL concentrations and its functions are dependents of other oxidative and anti-oxidative particles. The oxLDL to low-density lipoprotein ratio (ox-LDL/LDL) and ox-LDL to high-density lipoprotein ratio (ox-LDL/HDL) as new lipid biomarkers may serve as ...
Mahtab, Motamed   +5 more
openaire   +2 more sources

LncRNA PVT1 knockdown alleviated ox-LDL-induced vascular endothelial cell injury and atherosclerosis by miR-153-3p/GRB2 axis via ERK/p38 pathway.

NMCD. Nutrition Metabolism and Cardiovascular Diseases, 2021
BACKGROUND AND AIMS LncRNA plasmacytoma variant translocation 1 (PVT1) plays a regulatory role in some cardiovascular diseases, but its role in atherosclerosis (AS) remains barely explored.
Junxia Guo   +8 more
semanticscholar   +1 more source

PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages

open access: yesCardiovascular Research, 2018
Abstract Aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to influence macrophage biology and modulate atherogenesis. We conducted this study to examine the regulation of scavenger receptors (SRs) (LOX-1, SRA, and CD36) and oxidized liporoptein cholesterol (ox-LDL) uptake in ...
Zufeng Ding   +7 more
semanticscholar   +3 more sources

LncRNA TUG1 regulates proliferation and apoptosis by regulating miR-148b/IGF2 axis in ox-LDL-stimulated VSMC and HUVEC.

Life Science, 2020
Vascular smooth muscle cell (VSMC) accumulation and endothelial cell dysfunction are associated with pathogenesis of atherosclerosis. Long noncoding RNA taurine up-regulated gene 1 (TUG1) has been reported to play an important role in cardiovascular ...
Xiaoguang Wu   +4 more
semanticscholar   +1 more source

Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway.

Toxicology and Applied Pharmacology, 2021
The formation of fat-laden foam cells plays an important role in the initiation and progression of atherosclerosis (AS). Amentoflavone (AF) is found in various traditional Chinese medicines, such as , which are used to treat cardiovascular diseases (CVDs)
Jialing Zhuang   +6 more
semanticscholar   +1 more source

Determination of Oxidized Low‐Density Lipoproteins (ox‐LDL) versus ox‐LDL/β2GPI Complexes for the Assessment of Autoimmune‐Mediated Atherosclerosis

Annals of the New York Academy of Sciences, 2007
Abstract:  The immunolocalization of oxidized low‐density lipoproteins (ox‐LDL), β2‐glycoprotein I (β2GPI), CD4+/CD8+ immunoreactive lymphocytes, and immunoglobulins in atherosclerotic lesions strongly suggested an active participation of the immune system in atherogenesis.
Luis R, Lopez   +4 more
openaire   +2 more sources

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