Results 231 to 240 of about 259,578 (273)

Autoantibodies to ox-LDL in Sjögren's syndrome: are they atheroprotective?

Clinical and experimental rheumatology, 2018
The higher incidence of atherosclerosis and cardiovascular disease (CVD) in patients with systemic autoimmune diseases cannot be attributed exclusively to traditional risk factors for CVD. Antibodies to oxidised Low Density Lipoprotein (ox-LDL) seem to have a crucial role in atherogenesis.Sera from 63 consecutive patients with primary Sjögren's ...
Ilir, Cinoku, Clio P, Mavragani, Costantinos C, Tellis, Adrianos, Nezos, Alexandros D, Tselepis, Haralampos M, Moutsopoulos   +5 more
openaire   +1 more source

PACS2 is required for ox‐LDL‐induced endothelial cell apoptosis by regulating mitochondria‐associated ER membrane formation and mitochondrial Ca2+ elevation

Experimental Cell Research, 2019
&NA; Oxidized low‐density lipoprotein (ox‐LDL)‐induced endothelial cell (EC) apoptosis is the initial step of atherogenesis and associated with Ca2+ overload.
Sanjiu Yu, Laiping Zhang, Chuan Liu, Jie Yang, Jihang Zhang, Lan Huang   +5 more
semanticscholar   +1 more source

Urolithin A attenuated ox-LDL-induced cholesterol accumulation in macrophages partly through regulating miR-33a and ERK/AMPK/SREBP1 signaling pathways.

Food & Function, 2020
Promoting cholesterol efflux from foam cells represents one of the therapeutic strategies for ameliorating atherosclerosis. Urolithin A (UA) has been shown before to attenuate ox-LDL induced endothelial dysfunction in endothelial cells with its anti ...
Qi-An Han, Dongfang Su, Chao Shi, Peifeng Liu, Yue Wang, B. Zhu, X. Xia   +6 more
semanticscholar   +1 more source

Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway

DNA and Cell Biology, 2020
Fibroblast growth factor 21 (FGF21) is a hormone-like member of the FGF family that is associated with cell death in atherosclerosis. However, its underlying mechanisms remain unclear. In this study, the effect of FGF21 on endothelial cell pyroptosis and
Jiao‐jiao Chen, J. Tao, Xiao-Lei Zhang, Linzhen Xia, Jun-fa Zeng, Hai Zhang, D. Wei, Y. Lv, Guohua Li, Zuo Wang   +9 more
semanticscholar   +1 more source

Circular RNA circ_0029589 regulates proliferation, migration, invasion, and apoptosis in ox-LDL-stimulated VSMCs by regulating miR-424-5p/IGF2 axis.

Vascular pharmacology, 2020
BACKGROUND Circular RNAs (circRNAs) have been identified to be critical mediators in the progression of atherosclerosis (AS). However, the exact roles and molecular mechanism of circ_0029589 in AS are far from understood. METHODS Vascular smooth muscle
Hui-peng Yu, Luosha Zhao, Yang Zhao, Jiayue Fei, Wenli Zhang   +4 more
semanticscholar   +1 more source

AB0948 Proinflammatory Cytokine and OX-LDL Levels in Fibromyalgia Patients

Annals of the Rheumatic Diseases, 2015
Background Although fibromyalgia (FM) is known a non-inflammatory condition, emerging data suggest that FM has an immunologic component. The levels of several inflammatory cytokines are abnormal in patients with FM and may play role in its pathogenesis.
Şenay Özdolap, F. Canpolat Kutu
openaire   +2 more sources

Cyclophilin A mediates the ox-LDL-induced activation and apoptosis of macrophages via autophagy

International Journal of Cardiology, 2017
Oxidized low-density lipoprotein (ox-LDL) is the most common inflammatory factor that mediates the activation and apoptosis of macrophages. Cyclophilin A (CyPA) is expressed following oxidative stress, hypoxia, and infection. However, the role of CyPA in the activation and apoptosis of macrophages is unclear.
Zhiqiang, Xue, Wei, Yuan, Jing, Li, Hong, Zhou, Lihua, Xu, Jiayi, Weng, Xiaoyang, Li, Xinru, Zhang, Zhongqun, Wang, Jinchuan, Yan   +9 more
openaire   +2 more sources

Antibodies against ox-LDL serum levels in patients with hepatocellular carcinoma.

Panminerva medica, 2003
Hepatocellular carcinoma (HCC) is a malignancy with high incidence worldwide. The related cachexia is induced by proinflammatory cytokines, responsible for a wide number of metabolic disorders, essentially including lipidic and oxidative metabolism.
MOTTA M, PISTONE G, FRANZONE AM, ROMEO MA, DI MAURO S, GIUGNO I, RUELLO P, MALAGUARNERA, Mariano   +7 more
openaire   +2 more sources

ox-LDL induces endothelial dysfunction by promoting Arp2/3 complex expression

Biochemical and Biophysical Research Communications, 2016
Oxidized low-density lipoproteins (ox-LDL) play a critical role in endothelial injury including cytoskeleton reorganization, which is closely related to actin-related protein 2/3 (Arp2/3) complex. The aim of this study was to investigate the role of Arp2/3 complex in ox-LDL-induced endothelial dysfunction.
Yao, Tang, Jianting, Zhao, Liming, Shen, Yiqi, Jin, Zhixuan, Zhang, Guoxiong, Xu, Xianchen, Huang   +6 more
openaire   +2 more sources

LncRNA H19/miR-let-7 axis participates in the regulation of ox-LDL-induced endothelial cell injury via targeting periostin.

International Immunopharmacology, 2019
Oxidized-low density lipoprotein (ox-LDL)-induced endothelial cell dysfunction is a crucial event in the pathogenesis of atherosclerosis (AS). Long noncoding RNAs (lncRNAs) have been shown to play important roles in this process.
Lei Cao, Zhe Zhang, Yong Li, Peiyong Zhao, Yuguo Chen   +4 more
semanticscholar   +1 more source