Results 221 to 230 of about 259,578 (273)

Zafirlukast prevented ox-LDL-induced formation of foam cells

Toxicology and Applied Pharmacology, 2020
Atherosclerosis (AS), a common arterial disease, is one of the main pathological roots of cardiovascular disease. The formation and accumulation of foam cells is an important event in early AS. An imbalance between cholesterol uptake and efflux is the primary cause of foam cell formation.
Qiang, Song, Zhi, Hu, Xinming, Xie, Hui, Cai   +3 more
openaire   +2 more sources

Sequencing Analysis of mRNA Profile in Endothelial Cells in Response to ox-LDL

Biochemical Genetics, 2021
The pathogenesis of atherosclerosis (AS) and abnormal endothelial cells apoptosis is a multifactorial biological process. Oxidized low density lipoprotein (ox-LDL) is a critical factor in the formation of AS. However, the exact mechanism is still not clear.
Dongmei Su, Li Yi, Lina Guan, Qian Li, Cuige Shi, Xu Ma   +5 more
openaire   +2 more sources

Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCs.

International Immunopharmacology, 2020
Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis.
Jinmeng Zhao, Xinyi Niu, Jinjin Yu, Xin Xiao, Wenqi Li, Lulu Zang, Zhen Hu, Paul Siu-Po Ip, Weifeng Li   +8 more
semanticscholar   +1 more source

The potentiation of ox-LDL induced apoptosis by inhibition of NF-κB

Life Sciences, 2000
We previously reported that oxidized low density lipoprotein (ox-LDL) induced apoptosis in vascular smooth muscle cells (VSMCs). However, the transcription factors important for apoptotic signalling have been little clarified. We investigated the involvement of nuclear factor-kappaB (NF-kappaB), by which apoptotic signalling is reported to be mediated,
E, Nishio, Y, Kanda, Y, Kuroki, Y, Watanabe   +3 more
openaire   +2 more sources

Tissue factor pathway inhibitor-2 is downregulated by ox-LDL and inhibits ox-LDL induced vascular smooth muscle cells proliferation and migration

Thrombosis Research, 2011
Tissue factor pathway inhibitor-2 (TFPI-2) is a member of the Kunitz-type family of serine protease inhibitors, which inhibits several matrix metalloproteinases activity involved in extracellular matrix degradation. Studies have shown low TFPI-2 expression in the shoulder regions of atherosclerotic plaques.
Bilian, Zhao, Xinping, Luo, Haiming, Shi, Duan, Ma   +3 more
openaire   +2 more sources

Anti-ox-LDL and Anticardiolipin Autoantibodies in Patients After Cardiac Transplantation

Transplantation Proceedings, 2007
Among cardiac transplantation (OHT) of coronary arterial disease, the pathogenesis can be associated with autoimmunologic effects due to oxidative lipoprotein modification and their change in antigenicity. These factors may lead to lipoprotein vascular changes observed in antiphospholipid syndrome or systemic lupus erythematosus.
M, Szewczyk, T, Wielkoszyński, M, Zakliczyński, M, Zembala, M, Szumska-Kostrzewska   +4 more
openaire   +2 more sources

miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL

Journal of Cellular Physiology, 2020
AbstractAtherosclerosis is one of the leading causes of morbidity and mortality, mainly due to the immune response triggered by the recruitment of monocytes/macrophages in the artery wall. Accumulating evidence have shown that matrix stiffness and oxidized low‐density lipoproteins (ox‐LDL) play important roles in atherosclerosis through modulating ...
Jing Li, Sufang Wang, Yuhui Li, Nu Zhang, Michael Gribskov, Xi Zhang, Min Lin, Dongyan Shao, Chen Zhang, Liangliang Dai, Chuanguang Qin, Xianglong Duan, Juntang Li, Feng Xu, Hui Yang   +14 more
openaire   +2 more sources

Effects of Ox‐LDL on Number and Activity of Circulating Endothelial Progenitor Cells

Drug and Chemical Toxicology, 2004
Endothelial dysfunction is thought to play a crucial role in the pathogenesis of atherosclerosis induced by ox-LDL. Recently, a variety of evidence suggested that endothelial progenitor cells (EPCs) participated in neovascularization and reendothelialization.
Xingxiang, Wang, Junzhu, Chen, Qianmin, Tao, Junhui, Zhu, Yunpeng, Shang   +4 more
openaire   +2 more sources

Subcellular localization of DAXX influence ox-LDL induced apoptosis in macrophages

Molecular Biology Reports, 2014
Here we aimed to evaluate the effects of DAXX subcellular localization on ox-LDL induced macrophages apoptosis. Cytoplasmic localization vector DAXX-W621A and nuclear localization vector DAXX-S667A were constructed by point mutation in DAXX. Blank vector, full length DAXX, DAXX-W621A, DAXX-S667A was transfect into RAW264.7 cells, respectively. Then the
Guozuo, Xiong, Lin, Li, Shaowei, Sun, Tianping, Li, Duanfang, Liao, Chang, Shu, Qinhui, Tuo   +6 more
openaire   +2 more sources

Gypenoside inhibits ox-LDL uptake and foam cell formation through enhancing Sirt1-FOXO1 mediated autophagy flux restoration.

Life Science, 2020
BACKGROUND Gypenoside (GP) is the major bioactive constituent of G. pentaphyllum, a traditional Chinese medicine. It has been reported that GP can affect autophagy and lipid metabolism in cultured cells.
Hui Bo, X. Hou, Ruhui Liu, Xiao-hong Liu, Zhaohui Hu   +4 more
semanticscholar   +1 more source