Results 241 to 250 of about 40,843 (302)

Bioisosterism: 1,2,4‐Oxadiazole Rings

ChemMedChem, 2023
AbstractAlthough studies in drug discovery have gained momentum in recent years, the conversion of drugs in use today into less toxic derivatives with pharmacologically superior properties is still of great importance in drug research. Bioisosterism facilitates the conversion of drugs into derivatives that present more positive pharmacological and ...
Merve Camci, Nilgün Karali
openaire   +3 more sources

Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.

Journal of Medicinal Chemistry, 2023
Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family mainly targeting cytosolic nonhistone substrates, such as α-tubulin, cortactin, and heat shock protein 90 to regulate cell proliferation, metastasis, invasion, and mitosis in tumors.
L. Ripa, Jenny Sandmark, Glyn Hughes, Igor Shamovsky, Anders Gunnarsson, Julia Johansson, A. Llinàs, Mia Collins, Bomi Jung, Anna Novén, Nils Pemberton, M. Mogemark, Yao Xiong, Qing Li, Stefan Tångefjord, M. Ek, Annika Åstrand   +16 more
semanticscholar   +1 more source

Oxadiazole: A highly versatile scaffold in drug discovery

Archiv der Pharmazie, 2022
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the problem associated with the confluence of many commercially available drugs with different pharmacological profiles.
N. Desai, Jahnvi D. Monapara, Aratiba M. Jethawa, V. Khedkar, B. Shingate   +4 more
semanticscholar   +1 more source

Unique Carbazole-Oxadiazole Derivatives as New Potential Antibiotics for Combating Gram-Positive and -Negative Bacteria.

Journal of Medicinal Chemistry, 2022
Novel carbazole-oxadiazoles were developed as new potential antibacterial agents to combat dreadful resistance. Some target compounds displayed predominant inhibitory effects on the tested Gram-positive and -negative bacteria, and carbazole-oxadiazoles ...
Yun-Peng Xie, Nagarajan Sangaraiah, J. Meng, Cheng‐He Zhou   +3 more
semanticscholar   +1 more source

Synthetic Transformation of 4-fluorobenzoic acid to 4-fluorobenzohydrazide Schiff Bases and 1,3,4-Oxadiazole Analogs having DPPH Radical Scavenging Potential

Letters in Drug Design & Discovery, 2022
Synthesis of 4-fluorobenzohydrazide Schiff bases and 1,3,4-oxadiazole analogs has DPPH radical scavenging potential. Synthetic antioxidants are widely used because they are effective and cheaper than natural antioxidants.
Momin Khan, Zala Fazal, Aftab Alam, M. Ibrahim, Tehseen Ali, Mahboob Ali, Hafiz Danyal Khan   +6 more
semanticscholar   +1 more source

Enhancement of Energetic Performance through the Construction of Trinitromethyl Substituted β-Bis(1,2,4-oxadiazole).

Journal of Physical Chemistry Letters, 2022
Halogen-free substitutions of ammonium perchlorate (AP), which meet the requirements of high density, high performance, and acceptable stability, have been a subject of scientific research for many years.
Jinya Zhang, Jinxiong Cai, Nihan Chen, Teng Fei, Chunlin He, S. Pang   +5 more
semanticscholar   +1 more source

Review of the biological activities of heterocyclic compounds comprising oxadiazole moieties.

Current Topics in Medicinal Chemistry, 2022
The oxadiazole core is considered as a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole.
B. Ruan, Qinglei Guo, Qingshan Li, Lu-Zhi Li, G. S. Deora, Ben-Guo Zhou   +5 more
semanticscholar   +1 more source