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Dose-banding studies on oxaliplatin [PDF]
, 2016 Oxaliplatin is an anticancer drug widely used in cancer chemotherapy. This thesis evaluates whether a specific dose-banding scheme for oxaliplatin could replace the individual dosing method that is currently used in the oxaliplatin administration.
Xiaoqing, Liu
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, 2017 755 Background: Oxaliplatin-based chemotherapy is commonly used chemotherapy in the adjuvant setting for colorectal cancer patients. In clinical practice, those patients may be retreated with oxaliplatin after relapse.
Minkyu Jung +3 more
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Oxaliplatin treatment in vivo experiments.
, 2014 (A) Oxaliplatin treatment significantly inhibited the MHCC97H cells s.c. tumor. (B) GS-treated MHCC97H cells s.c. tumors were orthotopically transplanted into livers of other mice, and oxaliplatin treatment of these mice still produced significant ...
Ju-Bo Zhang (390858) +11 more
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Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons
Molecular Pain, 2010 Background Oxaliplatin chemotherapy induced neuropathy is a dose related cumulative toxicity that manifests as tingling, numbness, and chronic pain, compromising the quality of life and leading to discontinued chemotherapy.
Anand Praveen, Otto William R, Anand Uma
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton +8 more
wiley +1 more source
, 2015 Mitsukuni Suenaga,1 Nobuyuki Mizunuma,1 Satoshi Matsusaka,1 Eiji Shinozaki,1 Masato Ozaka,1 Mariko Ogura,1 Toshiharu Yamaguchi21Department of Gastroenterology, 2Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation ...
Shinozaki E +6 more
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu +3 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward oxaliplatin due to yet-unknown ...
Huei-Yu Chen +5 more
doaj +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Increase in spleen volume as a predictor of oxaliplatin toxicity
, 2018 Alissar El Chediak,1 Ali A Haydar,2 Ayman Hakim,1 Sarah Abdel Massih,1 Lara Hilal,3 Deborah Mukherji,1 Sally Temraz,1 Ali Shamseddine1 1Department of Internal Medicine, Division of Hematology-Oncology, American University of Beirut-Medical Center ...
Mukherji D +7 more
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