Results 221 to 230 of about 81,306 (284)

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Beyond the Monolayer: Leveraging 3D Culture Systems to Decode Mechanisms of Drug Resistance and Therapeutic Vulnerabilities in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Two‐dimensional (2D) monolayer cultures remain the workhorse of colorectal cancer (CRC) research and high‐throughput screening (HTS), yet they poorly recapitulate tissue architecture, extracellular matrix (ECM) cues, metabolic gradients, and multicellular heterogeneity that govern drug response in vivo. Over the past decade, three‐dimensional (
Sarah J. Harmych, Bhuminder Singh
wiley   +1 more source

Advances in therapeutic approaches to gastric cancer. [PDF]

CA Cancer J Clin
Wang F, Wang ZX, Zhang YJ, He Y, Ji JF, Li YF, Qu XJ, Ba Y, Yuan SQ, Xu RH.   +9 more
europepmc   +1 more source

Basal Marker ΔNp63α Is Enriched in Pancreatic Cancer Metastases but Not in Primary Tumors Post‐Chemotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer cells within a single pancreatic ductal adenocarcinoma (PDAC) are most often heterogeneous in their expression of the basal or classical transcriptional program. Predominance of the basal subtype has been associated with poorer patient outcomes and increased resistance to chemotherapy.
Daniel H. Ryan, Yuuki Ohara, Michael J. Kruhlak, Xianyu Zhang, Miao Lin, Chin‐Hsien Tai, Christine Alewine   +6 more
wiley   +1 more source

FOLFOX-based transarterial infusion chemotherapy for unresectable colorectal cancer: protocol of an open-label, multicentre, randomised, controlled, phase II trial. [PDF]

BMJ Open
Wang J, Sun Y, Chen L, Wang Z, Li K, Guo Y, Yao L, Duan L, Liu Q.   +8 more
europepmc   +1 more source

Real‐World Overall Survival With Abiraterone Acetate and Enzalutamide in Patients With Chemotherapy‐Naïve Metastatic Castration‐Resistant Prostate Cancer From the Flatiron Electronic Health Records Database

Cancer Medicine, Volume 15, Issue 10, October 2026.
This real‐world study of the Flatiron Health database found that first‐line treatment with abiraterone versus enzalutamide was associated with significantly shorter overall survival, treatment duration, and time to subsequent treatment in patients with chemotherapy‐ and androgen receptor pathway inhibitor‐naïve metastatic castration‐resistant prostate ...
Daniel J. George, Jasmina I. Ivanova, Maëlys Touya, Betty Thompson, Jonathan Assayag, Benjamin Li, Nikolaos Kountouris, Gordon Siu, Stephen J. Freedland   +8 more
wiley   +1 more source

PUM2 inhibits ferroptosis and enhances oxaliplatin resistance in COAD via the NEDD4L/NRF2 axis. [PDF]

Transl Oncol
Xie J, Dong K, Wu J, Cheng X, Wang S, Zhang H.   +5 more
europepmc   +1 more source

Increased Lymphocyte Proportions as a Candidate Biomarker for Immune‐Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitors and Chemotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Combination therapy comprising immune checkpoint inhibitors (ICIs) and chemotherapy is standard treatment for many cancer types. However, the management of adverse events (AEs) induced by combination therapy is more complicated than that of AEs induced by ICI monotherapy.
Nanami Ito, Yoshihiko Tasaki, Yosuke Sugiyama, Takehiro Uemura, Keisuke Yokota, Ryo Ogawa, Takaya Shimura, Daisuke Kawakita, Yumi Wanifuchi‐Endo, Yoshihisa Mimura, Moeko Iida, Kunihiro Odagiri, Yuka Kimura, Misato Tomita, Yuji Hotta, Tatsuya Toyama, Shinichi Iwasaki, Hiromi Kataoka, Shuji Takiguchi, Katsuhiro Okuda, Akio Niimi, Yoko Furukawa‐Hibi   +21 more
wiley   +1 more source

Concurrent Intestinal Tuberculosis and Colon Cancer in a Young Patient: A Diagnostic Challenge. [PDF]

ACG Case Rep J
A A, Kini R, Karunakaran PK.
europepmc   +1 more source

Artificial Intelligence in Gastric Cancer: Diagnostic, Prognostic, and Predictive Developments, Evidence Maturity, and Translational Challenges

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) remains a major global health burden characterized by substantial heterogeneity in diagnosis, prognosis, and treatment response. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has been increasingly investigated for the analysis of endoscopic images, radiological scans, whole‐
Chong Chen, Weisong Xu, Tong Wu, Junpeng Zhao, Xuebing Xu, Mingbing Xiao, Kang Xu   +6 more
wiley   +1 more source