Results 31 to 40 of about 133,537 (299)

Oxaliplatin induces ferroptosis and oxidative stress in HT29 colorectal cancer cells by inhibiting the Nrf2 signaling pathway

Experimental and Therapeutic Medicine, 2022
Oxaliplatin is a third-generation platinum drug that is used as first-line chemotherapy for colorectal cancer (CRC). Ferroptosis has been demonstrated to induce cell death and oxidative stress in CRC.
Ben Liu, Hong Wang
semanticscholar   +1 more source

KIAA1199 promotes oxaliplatin resistance and epithelial mesenchymal transition of colorectal cancer via protein O-GlcNAcylation

Translational Oncology, 2023
Oxaliplatin is a commonly used platinum drug for colorectal cancer (CRC). However, the treatment of CRC by oxaliplatin usually fails because of drug resistance, which results in a huge challenge in the therapy of CRC.
Qingling Hua, Yuanyuan Lu, Dingxiang Wang, Jie Da, Wanren Peng, Guoping Sun, Kangsheng Gu, Hua Wang, Yanzhe Zhu   +8 more
doaj   +1 more source

Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis. [PDF]

, 2018
BackgroundContinuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel and oxaliplatin have been shown to be active in patients with pancreatic cancer.
Bedford, Rudolph, Donahue, Timothy, Hines, O Joe, Hoos, William, Isacoff, William H, Rahib, Lola, Reber, Howard A, Upfill-Brown, Alexander   +7 more
core   +1 more source

Predicting effects on oxaliplatin clearance: in vitro, kinetic and clinical studies of calcium- and magnesium-mediated oxaliplatin degradation

Scientific Reports, 2017
This study evaluated the impact of calcium and magnesium on the in vitro degradation and in vivo clearance of oxaliplatin. Intact oxaliplatin and Pt(DACH)Cl2 were measured in incubation solutions by HPLC-UV.
Catherine H. Han, Prashannata Khwaounjoo, Andrew G. Hill, Gordon M. Miskelly, Mark J. McKeage   +4 more
doaj   +1 more source

A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract [PDF]

, 2016
Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with ...
E. Soulis, F. Y. Coxon, J. S. Graham, K. Boyd, L. R. Wall, M. Highley, M. M. Eatock, P. Bützberger-Zimmerli, S. Harden, T. R. J. Evans, T. S. Maughan   +10 more
core   +1 more source

Hemoglobin, Body Mass Index, and Age as Risk Factors for Paclitaxel- and Oxaliplatin-Induced Peripheral Neuropathy

JAMA Network Open, 2021
Key Points Question Are pretreatment blood-based and clinical factors associated with chemotherapy-induced peripheral neuropathy (CIPN) persistence posttreatment in patients who have received paclitaxel or oxaliplatin?
D. Mizrahi, Susanna B. Park, Tiffany Li, H. Timmins, T. Trinh, K. Au, E. Battaglini, D. Wyld, R. Henderson, Peter Grimison, H. Ke, Peter Geelan-Small, J. Marker, B. Wall, D. Goldstein   +14 more
semanticscholar   +1 more source

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy [PDF]

, 2013
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer ...
Chan, Kiat-Hwa, Gopalan, Began, Hauser, Charlotte A. E., Joshi, Mangesh, Lakshmanan, Anupama, Lam, Dang Hoang, Mishra, Archana, Reithofer, Michael R., Wang, Shu   +8 more
core   +1 more source

A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance

Communications Chemistry, 2022
Clinical efficacy of oxaliplatin is frequently limited by severe adverse effects and therapy resistance. Acquired insensitivity to oxaliplatin is, at least in part, associated with elevated levels of glutathione (GSH).
Philipp Fronik, M. Gutmann, P. Vician, M. Stojanović, Alexander Kastner, P. Heffeter, C. Pirker, B. Keppler, W. Berger, C. Kowol   +9 more
semanticscholar   +1 more source

Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat

Journal of Pharmacological Sciences, 2014
.: The acute peripheral neuropathy induced by oxaliplatin treatment occurs very frequently and is aggravated by exposure to cold. Goshajinkigan (GJG), a traditional Japanese (kampo) medicine, was recently shown to be effective against oxaliplatin-induced
Keita Mizuno, Toru Kono, Yasuyuki Suzuki, Chika Miyagi, Yuji Omiya, Kanako Miyano, Yoshio Kase, Yasuhito Uezono   +7 more
doaj   +1 more source

Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin vs Sorafenib Alone for Hepatocellular Carcinoma With Portal Vein Invasion: A Randomized Clinical Trial.

JAMA Oncology, 2019
Importance Sorafenib is the first-line treatment for hepatocellular carcinoma with portal vein invasion; however, it has shown unsatisfactory survival benefit. Sorafenib plus hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, fluorouracil, and
M. He, Qi-Jiong Li, Ruhai Zou, Jingxian Shen, Wanqiang Fang, Guosheng Tan, Yuanmin Zhou, Xiaoping Wu, Li Xu, Wei Wei, Yong Le, Zhongguo Zhou, Ming Zhao, Ying Guo, R. Guo, Minshan Chen, M. Shi   +16 more
semanticscholar   +1 more source