Results 31 to 40 of about 81,306 (284)

Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord

Journal of Pharmacological Sciences, 2016
Oxaliplatin is a chemotherapeutic agent that is effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia is a serious side effect of oxaliplatin treatment.
Ken Yamamoto, Mayuko Tsuboi, Toshie Kambe, Kenji Abe, Yoshihiko Nakatani, Kazuyoshi Kawakami, Iku Utsunomiya, Kyoji Taguchi   +7 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

The Role and Mechanism of Innate Immune Regulation in Overcoming Oxaliplatin Resistance and Enhancing Anti-Tumor Efficacy in Colorectal Cancer

Pharmaceuticals
Background/Objectives: The reversal effect of cGAMP, as a STING pathway regulator, on oxaliplatin resistance in colorectal cancer was investigated, and its mechanism was proposed.
Xiaoqing Wang, Meili Xi, Xing Lu, Xiangshi Tan   +3 more
doaj   +1 more source

Maintenance of stemness in oxaliplatin-resistant hepatocellular carcinoma is associated with increased autocrine of IGF1.

PLoS ONE, 2014
BackgroundEvidence suggests that many types of cancers are composed of different cell types, including cancer stem cells (CSCs). We have previously shown that the chemotherapeutic agent oxaliplatin induced epithelial-mesenchymal transition, which is ...
Yang Bu, Qing-An Jia, Zheng-Gang Ren, Ju-Bo Zhang, Xue-Mei Jiang, Lei Liang, Tong-Chun Xue, Quan-Bao Zhang, Yan-Hong Wang, Lan Zhang, Xiao-Ying Xie, Zhao-You Tang   +11 more
doaj   +1 more source

Hypersensitivity reaction and acute immune-mediated thrombocytopenia from oxaliplatin: two case reports and a review of the literature

Journal of Hematology & Oncology, 2010
Background Oxaliplatin is a platinum compound used in the treatment of gastrointestinal malignancies, including colorectal cancer. The incidence of hypersensitivity reaction in patients receiving oxaliplatin is approximately 15%, with severe reaction ...
Aster Richard H, Curtis Brian R, Chen Chien-Shing, Stevens W, Bautista Marnelli A, Hsueh Chung-Tsen   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Genetic polymorphisms of SCN9A are associated with oxaliplatin-induced neuropathy [PDF]

, 2017
Background Oxaliplatin is a chemotherapy agent active against digestive tumors. Peripheral neuropathy is one of the most important dose-limiting toxicity of this drug.
Zambrana Tébar, Francisco, Rodriguez Antona, Cristina, María Apellániz-Ruiz, Sereno, Mar\ueda, Sánchez-Barroso, Lara, Francisco Zambrana Tébar, Rodriguez-Salas, Nuria, Gutiérrez Gutiérrez, Gerardo, Gómez Raposo, César, Apellániz Ruiz, María, Falagan, Sandra, G\uf3mez-Raposo, C\ue9sar, L\uf3pez-G\uf3mez, Miriam, María Sereno, Lara Sánchez-Barroso, Nuria Rodriguez-Salas, Tébar, Francisco Zambrana, Rubio, Juan Moreno, María Merino, Gerardo Gutiérrez-Gutiérrez, Cristina Rodríguez-Antona, Miriam López-Gómez, Casado, Enrique, Gutiérrez-Gutiérrez, Gerardo, López Gómez, Miriam, Juan Moreno Rubio, Rodr\uedguez-Antona, Cristina, Moreno Rubio, Juan, Apellániz-Ruiz, María, Sánchez Barroso, Lara, Merino, Mar\ueda, T\ue9bar, Francisco, Sandra Falagan, Rodríguez Salas, Nuria, S\ue1nchez-Barroso, Lara, César Gómez-Raposo, Merino, María, Gómez-Raposo, César, Enrique Casado, Guti\ue9rrez-Guti\ue9rrez, Gerardo, Apell\ue1niz-Ruiz, Mar\ueda, Rodríguez-Antona, Cristina, Sereno, María, Rubio, Juan, López-Gómez, Miriam   +44 more
core   +1 more source

Influence of ring modifications on nucleolar stress caused by oxaliplatin-like compounds [PDF]

, 2022
Oxaliplatin, a platinum compound in broad clinical use, can induce cell death through a nucleolar stress pathway rather than the canonical DNA damage response studied for other Pt(II) compounds.
Haley, Smith, Christine, McDevitt, Andres, Guerrero, Victoria, DeRose   +3 more
core   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Preventive effect of PC-SOD on oxaliplatin-induced peripheral neuropathy in rats

BMC Neuroscience
Background Oxaliplatin is widely used as a chemotherapeutic agent for treating various cancers, including colorectal cancer. However, oxaliplatin-induced peripheral neuropathy diminishes the quality of life of patients.
Zhiwei Qiao, Yuki Uchihara, Naohiro Tsukiyama, Shota Akimoto, Noriko Kaji, Koichiro Fukuda, Tohru Mizushima   +6 more
doaj   +1 more source