Results 111 to 120 of about 2,234,624 (258)

Induction of resistance to oxaliplatin in cancer by a microRNA/Fem1B/Gli1 pathway. [PDF]

, 2023
Colorectal cancer is among the most common cancers worldwide and a frequent cause of cancer related deaths. Oxaliplatin is the first line chemotherapeutics for treatment, but the development of resistance leads to recurrence of oxaliplatin insensitive ...
Huang, Chih-Yang, Seldin, Marcus, Kuo, Wei-Wen, Su, Yi-Chen, Bournique, Elodie, Vélez, Leandro, Kaiser, Peter, Buisson, Rémi, Metzen, Landon   +8 more
core  

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue

, 2009
Background: Oxaliplatin and related chemotherapeutic drugs cause painful chronic peripheral neuropathies in cancer patients. We investigated changes in neuronal size profiles and neurofilament immunoreactivity in L5 dorsal root ganglion (DRG) tissue of
Subramaniam, J (15583175), Jong, NN (15576410), McKeage, MJ (15576416), Johnson Liu (14742571), Jamieson, SMF (15583178), Connor, B (15583181)   +5 more
core  

Reduction Process of Pt(IV) Complexes With Axial Acetato Ligands by Ascorbic Acid; Comparison of Experimental and Computational Tools

Chemistry – A European Journal, EarlyView.
Comparison of experimental and calculated rate constants for reduction of selected Pt(IV) complexes by ascorbic acid (AA) in water solution at pH = 7. ABSTRACT In the present work, the reduction mechanism of several Pt(IV) complexes bearing two axial acetato ligands by ascorbic acid (AA) was investigated.
Ondřej Tichý, Patrick A. Yassemipour, Christian R. Kowol, Jaroslav V. Burda   +3 more
wiley   +1 more source

Early responses of the STAT3 pathway to platinum drugs are associated with cisplatin resistance in epithelial ovarian cancer

Brazilian Journal of Medical and Biological Research, 2013
Cisplatin resistance remains one of the major obstacles when treating epithelial ovarian cancer. Because oxaliplatin and nedaplatin are effective against cisplatin-resistant ovarian cancer in clinical trials and signal transducer and activator of ...
W.J. Sheng, H. Jiang, D.L. Wu, J.H. Zheng   +3 more
doaj   +1 more source

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]

Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators, GBD 2021 Antimicrobial Resistance Collaborators   +1 more
core   +1 more source

Unraveling the Multimodal Oncogenic Network of KITENIN: From Metabolic Reprogramming and Microenvironment Remodeling to Targeted Interventions

Cancer Nexus, EarlyView.
ABSTRACT KAI1 C‐terminal interacting tetraspanin (KITENIN) is an emerging oncogenic regulator associated with tumorigenesis, metastasis, therapeutic resistance, and poor clinical outcomes. Mechanistically, KITENIN promotes tumor cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) by activating oncogenic pathways ...
Niaz Mahmood Tanoy, Zarin Tasnim, Md Shiblee Sadik Sabuj, Tanvir Ahmed, Md Abdul Momin, Md Sadekuzzaman, Sumaia Islam Mow, Md Aktaruzzaman, Md Rashedunnabi Akanda   +8 more
wiley   +1 more source

The Role of Prostaglandin E2 Signaling in Acquired Oxaliplatin Resistance

, 2017
The platinum-base chemotherapeutic agent, oxaliplatin, is used to treat metastatic colorectal cancer (CRC). Unfortunately, nearly all patients develop acquired resistance to oxaliplatin after long-term use, limiting its therapeutic efficacy.
Huang, Huakang
core   +1 more source

Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116.

PLoS ONE, 2012
Combination treatment with endostar, a novel modified endostatin, and cytotoxic chemotherapies showed a survival benefit in Chinese clinical trials. However, the exact mechanism for this synergism remains unclear.
Fengyan Jin, Huifan Ji, Chunshu Jia, Ulf Brockmeier, Dirk M Hermann, Eric Metzen, Yingqiao Zhu, Baorong Chi   +7 more
doaj   +1 more source