Results 1 to 10 of about 758 (80)
PLoS Neglected Tropical Diseases, 2020 Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals ...
Meghan A Guzman +11 more
doaj +2 more sources
The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase
Memorias do Instituto Oswaldo Cruz, 2006 Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites.
Livia Pica-Mattoccia +5 more
doaj +2 more sources
Parasites & Vectors, 2018 Background Schistosomiasis is one of the most harmful parasitic diseases worldwide, praziquantel being the only drug in widespread use to treat it. We recently demonstrated that ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine (Fc-OXA, Rc ...
Valentin Buchter +3 more
doaj +2 more sources
Altered Response of Strain of Schistosoma mansoni to Oxamniquine and Praziquantel
Memorias do Instituto Oswaldo Cruz, 2002 The susceptibility of a fourth generation Ouh strain (Paranapanema Valley, São Paulo, Brazil) of Schistosoma mansoni to oxamniquine (OXA) and praziquantel (PZQ) was studied.
Patrícia Ivana Pires Bonesso-Sabadini +1 more
doaj +2 more sources
Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
Memorias do Instituto Oswaldo Cruz, 2008 The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni.
Neusa Araújo +4 more
doaj +2 more sources
Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
Memorias do Instituto Oswaldo Cruz, 2000 After three successive treatments with oxamniquine the continuing elimination of Schistosoma mansoni eggs was observed in patients, who came from various regions of Brazil, with different clinical forms of schistosomiasis.
Maria José Conceição +2 more
doaj +2 more sources
Association of oxamniquine praziquantel and clonazepam in experimental Schistosomiasis mansoni
Memorias do Instituto Oswaldo Cruz, 2008 The antischistosomal activity of clonazepam, when administered alone or in association with oxamniquine and praziquantel, was experimentally evaluated in mice infected with Schistosoma mansoni.
Neusa Araujo +3 more
doaj +2 more sources
Bulletin of the World Health Organization, 2003 OBJECTIVE: To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide drugs, and to compare the accuracy of faecal examination with the accuracy of oogram in testing for Schistosoma mansoni ...
Ferrari M.L.A. +4 more
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Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis
PLoS Pathogens, 2023 Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni, S. haematobium, and S. japonicum. Praziquantel (PZQ) is the method of choice for treatment. Due to constant selection pressure, there is an urgent need for new therapies
Sevan N. Alwan +5 more
semanticscholar +2 more sources
Baixa eficácia da associação oxamniquine e praziquantel na cura da esquistossomose mansônica
Revista da Sociedade Brasileira de Medicina Tropical, 1986 Em uma área endêmica onde havia interrupção da transmissão, foram tratados 164 esquistossomóticos com a associação oxamniquine e praziquantel em doses reduzidas.
R. Dietze, A. Prata
doaj +3 more sources