Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis. [PDF]
PLoS Pathog, 2023 AbstractHuman schistosomiasis is a neglected tropical disease caused bySchistosoma mansoni, S. haematobium,andS. japonicum.Praziquantel (PZQ) is the method of choice for treatment. Due to constant selection pressure, there is an urgent need for new therapies for schistosomiasis. Previous treatment ofS.
Alwan SN +5 more
europepmc +6 more sources
An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans. [PDF]
PLoS Neglected Tropical Diseases, 2020 Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals ...
Meghan A Guzman +11 more
doaj +4 more sources
Resistance of schistosomes to hycanthone and oxamniquine [PDF]
Memorias do Instituto Oswaldo Cruz, 1989 Genetic crosses between phenotypically resistant and sensitive schistosomes demonstrated that resistance to hycanthone and oxamniquine behaves like a recessive trait, thus suggesting that resistance is due to the lack of some factor. We hypothesized that,
Donato Cioli +2 more
doaj +6 more sources
Baixa eficácia da associação oxamniquine e praziquantel na cura da esquistossomose mansônica [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1986 Em uma área endêmica onde havia interrupção da transmissão, foram tratados 164 esquistossomóticos com a associação oxamniquine e praziquantel em doses reduzidas.
R. Dietze, A. Prata
doaj +4 more sources
Hycanthone e oxamniquine no tratamento de crianças portadoras de S. mansoni [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1976 Os autores apresentam resultado de tratamento com Hycanthone e com Oxamniquine efetuado em grupos de 36 crianças de 6 - 15 anos de idade, portadoras de S.
Maria Zelia Rouquayrol +5 more
doaj +4 more sources
The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites.
Livia Pica-Mattoccia +5 more
doaj +2 more sources
Comparação entre praziquantel e oxamniquine no tratamento da esquistossomose mansoni [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1983 Tratamos 120 pacientes masculinos com idade de 17 a 19 anos, portadores de esquistossomose mansoni nas formas intestinal e hepatointestinal, pareados de acordo com o número de ovos por grama de fezes.
Antônio Emanuel, Aluízio Prata
doaj +4 more sources
RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1997 A strain of Schistosoma mansoni (R1) was isolated from patient previously submitted to four treatments with oxamniquine, and to another one with praziquantel. The results obtained with chemotherapeutic test, by using oxamniquine in mice infected with the
M.Z. COELHO +2 more
doaj +2 more sources
Treatment of patients with Schistosomiasis mansoni: a double blind clinical trial comparing praziquantel with oxamniquine [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1986 A double-blind clinical trial involving 120 patients with chronic schistosomiasis was carried out to compare the tolerability and efficacy of praziquantel and oxamniquine. The patients were randomly allocated into two groups.
Luiz Caetano da Silva +7 more
doaj +2 more sources
Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma Species [PDF]
PharmaceuticsSchistosomiasis, a neglected tropical disease affecting over 250 million people worldwide, relies on praziquantel (PZQ) as its sole treatment. However, PZQ has significant limitations, including inactivity against juvenile worms, inability to prevent ...
Sevan N. Alwan +4 more
doaj +2 more sources