Results 21 to 30 of about 2,441 (215)

Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni [PDF]

, 2015
Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple ...
Altamura, Sergio, Bresciani, Alberto, Gennari, Nadia, GUIDI, ALESSANDRA, LALLI, CRISTIANA, Ruberti, Giovina   +5 more
core   +17 more sources

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? [PDF]

Int J Parasitol Drugs Drug Resist, 2020
Anastasia Rugel, M. Guzman, Alexander B Taylor, Frédéric D. Chevalier, Reid S Tarpley, Stanton F. McHardy, Xiaohang Cao, S. Holloway, T. Anderson, P. Hart, P. LoVerde   +10 more
semanticscholar   +2 more sources

The role of the host gut microbiome in the pathophysiology of schistosomiasis

Parasite Immunology, Volume 45, Issue 4, April 2023., 2023
Abstract The pathophysiology of schistosomiasis is linked to the formation of fibrous granulomas around eggs that become trapped in host tissues, particularly the intestines and liver, during their migration to reach the lumen of the vertebrate gut. While the development of Schistosoma egg‐induced granulomas is the result of finely regulated crosstalk ...
Klara A. Stark, Gabriel Rinaldi, Alba Cortés, Alice Costain, Andrew S. MacDonald, Cinzia Cantacessi   +5 more
wiley   +1 more source

Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach**

ChemistryOpen, Volume 11, Issue 2, February 2022., 2022
Combined in silico machinery, consisting of long‐ and short‐range molecular interaction methods is capable of filtering large compound databases, yielding a good candidate for a receptor. The advantage of this approach is a fast assessment of a candidate, starting from basic information on both protein and small organic molecule – FASTA sequence and ...
Milan Sencanski, Vladimir Perovic, Jelena Milicevic, Tamara Todorovic, Radivoje Prodanovic, Veljko Veljkovic, Slobodan Paessler, Sanja Glisic   +7 more
wiley   +1 more source

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

Clinical Pharmacology &Therapeutics, Volume 109, Issue 4, Page 1136-1146, April 2021., 2021
The intestinal epithelium represents a natural barrier against harmful xenobiotics, while facilitating the uptake of nutrients and other substances. Understanding the interaction of chemicals with constituents of the intestinal epithelium and their fate in the body requires quantitative measurement of relevant proteins in in vitro systems and ...
Zubida M. Al‐Majdoub, Narciso Couto, Brahim Achour, Matthew D. Harwood, Gordon Carlson, Geoffrey Warhurst, Jill Barber, Amin Rostami‐Hodjegan   +7 more
wiley   +1 more source

Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni

bioRxiv, 2020
At least 250 million people worldwide suffer from schistosomiasis, caused by Schistosoma worms. Genome sequences for several Schistosoma species are available, including a high-quality annotated reference for Schistosoma mansoni. There is a pressing need
Geetha Sankaranarayanan, Avril Coghlan, P. Driguez, M. Lotkowska, M. Sanders, N. Holroyd, A. Tracey, M. Berriman, G. Rinaldi   +8 more
semanticscholar   +1 more source

Comparação entre praziquantel e oxamniquine no tratamento da esquistossomose mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1983
Tratamos 120 pacientes masculinos com idade de 17 a 19 anos, portadores de esquistossomose mansoni nas formas intestinal e hepatointestinal, pareados de acordo com o número de ovos por grama de fezes.
Antônio Emanuel, Aluízio Prata
doaj   +3 more sources

Hycanthone e oxamniquine no tratamento de crianças portadoras de S. mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1976
Os autores apresentam resultado de tratamento com Hycanthone e com Oxamniquine efetuado em grupos de 36 crianças de 6 - 15 anos de idade, portadoras de S.
Maria Zelia Rouquayrol, Y.M. Almeida, E.G. Oliveira, Z.F. Silva, V.A.M. Pinto, J.E. Alencar   +5 more
doaj   +3 more sources

Variation in response of Schistosoma mansoni strains to schistosomicides

Revista do Instituto de Medicina Tropical de São Paulo, 1988
The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is ...
Luiz Cândido de Souza Dias, John I. Bruce, Gerald C. Coles   +2 more
doaj   +1 more source

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]

, 2009
Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
A. MBAYE, Alonso, Baard, Barakat, Botros, Botros, Cioli, D. CIOLI, D. ENGELS, G. COLES, Keiser, L. A. TCHUEM TCHUENTÉ, L. PICA-MATTOCCIA, M. J. DOENHOFF, Mwanakasale, N'Goran, P. HAGAN, Pica-Mattoccia, S. BOTROS, Stohler, Utzinger, V. SOUTHGATE, Van Wyk   +22 more
core   +2 more sources