Results 31 to 40 of about 1,042 (183)
Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis. [PDF]
ChemMedChemNovel organometallic derivatives of niridazole are designed, synthesized, and tested against Schistosoma mansoni. Schistosomiasis affects hundreds of millions of people worldwide, yet its chemotherapeutic treatment is based on the only drug available‐praziquantel (PZQ).
Karpstein T +10 more
europepmc +2 more sources
Activity of oxamniquine at skin, pulmonary and sexual maturation phases, on a Schistosoma mansoni strain (R1) previously reported as resistant at the adult phase [PDF]
Memorias do Instituto Oswaldo Cruz, 1998 Paulo Marcos Z Coelho +4 more
doaj +2 more sources
The role of the host gut microbiome in the pathophysiology of schistosomiasis
Parasite Immunology, Volume 45, Issue 4, April 2023., 2023 Abstract The pathophysiology of schistosomiasis is linked to the formation of fibrous granulomas around eggs that become trapped in host tissues, particularly the intestines and liver, during their migration to reach the lumen of the vertebrate gut. While the development of Schistosoma egg‐induced granulomas is the result of finely regulated crosstalk ...
Klara A. Stark +5 more
wiley +1 more source
ChemistryOpen, Volume 11, Issue 2, February 2022., 2022 Combined in silico machinery, consisting of long‐ and short‐range molecular interaction methods is capable of filtering large compound databases, yielding a good candidate for a receptor. The advantage of this approach is a fast assessment of a candidate, starting from basic information on both protein and small organic molecule – FASTA sequence and ...
Milan Sencanski +7 more
wiley +1 more source
Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics
Clinical Pharmacology &Therapeutics, Volume 109, Issue 4, Page 1136-1146, April 2021., 2021 The intestinal epithelium represents a natural barrier against harmful xenobiotics, while facilitating the uptake of nutrients and other substances. Understanding the interaction of chemicals with constituents of the intestinal epithelium and their fate in the body requires quantitative measurement of relevant proteins in in vitro systems and ...
Zubida M. Al‐Majdoub +7 more
wiley +1 more source
Variation in response of Schistosoma mansoni strains to schistosomicides
Revista do Instituto de Medicina Tropical de São Paulo, 1988 The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is ...
Luiz Cândido de Souza Dias +2 more
doaj +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1985 A random, double-blind, parallel group clinical trial program was carried out to compare praziquantel, a recently developed anti-helmintic drug, and oxamniquine, an already established agent for treating mansoni schistosomiasis.
Getúlio Leonel de Rezende
doaj +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1993 Os autores relatam caso clínico de paciente com esquistossomose mansônica, tratado com oxamniquine oral em dose única de 15 mg/kg, que apresenta como efeito colateral um bloqueio átrio-ventricular incompleto tipo Mobitz I, com parada sinusal e escape ...
José Carlos dos Santos Guitti +2 more
doaj +1 more source
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments
Chemistry – A European Journal, Volume 26, Issue 40, Page 8676-8688, July 17, 2020., 2020 There is an urgent clinical need for new agents to treat microbial infections and cancer, especially to combat resistance to current drugs. The successful strategy of conjugating existing drugs to organometallic fragments is illustrated with examples of conjugated organometallic metallocene sandwich and half‐sandwich complexes, especially ferrocene ...
Prinessa Chellan, Peter J. Sadler
wiley +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1987 A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of ...
K. Zwingenberger +6 more
doaj +1 more source