Results 31 to 40 of about 2,441 (215)
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments
Chemistry – A European Journal, Volume 26, Issue 40, Page 8676-8688, July 17, 2020., 2020 There is an urgent clinical need for new agents to treat microbial infections and cancer, especially to combat resistance to current drugs. The successful strategy of conjugating existing drugs to organometallic fragments is illustrated with examples of conjugated organometallic metallocene sandwich and half‐sandwich complexes, especially ferrocene ...
Prinessa Chellan, Peter J. Sadler
wiley +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1993 Os autores relatam caso clínico de paciente com esquistossomose mansônica, tratado com oxamniquine oral em dose única de 15 mg/kg, que apresenta como efeito colateral um bloqueio átrio-ventricular incompleto tipo Mobitz I, com parada sinusal e escape ...
José Carlos dos Santos Guitti +2 more
doaj +1 more source
Tratamento da esquitossomose mansoni pela oxamniquine em dose única, pela via oral [PDF]
, 1976 A oxamniquine em cápsulas foi usada no tratamento de 132 doentes com esquistossomose mansoni crônica, sendo 129 com a forma hepato-intestinal e 3 com a forma hepato-esplênica.
Figueiredo, José Fernando M. +3 more
core +3 more sources
In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine [PDF]
, 2016 This is an open-access article distributed under the terms of the Creative Commons Attribution License.[Background]: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma.
Dakir, El Habib +5 more
core +5 more sources
, 2020 Schistosomiasis is a disease of poverty affecting millions of people. Praziquantel (PZQ), with its strengths and weaknesses, is the only treatment available.
Valentin Buchter +7 more
semanticscholar +1 more source
Acute schistosomiasis, a diagnostic and therapeutic challenge [PDF]
, 2010 In non-endemic countries, acute (invasive) schistosomiasis (AS) is typically seen in non-immune travellers, whereas chronic schistosomiasis is more frequently diagnosed in immigrants.
Jauréguiberry, S. +2 more
core +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1987 A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of ...
K. Zwingenberger +6 more
doaj +1 more source
Drug repositioning : a machine-learning approach through data integration [PDF]
, 2013 Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels.
D'Amato, Mauro +6 more
core +1 more source
A prospective, randomized therapeutic trial for schistosomal specific nephropathy [PDF]
, 1989 A prospective, randomized therapeutic trial for schistosomal specific nephropathy. In this work 26 patients with schistosomal specific nephropathy were randomly distributed among three groups. Group I cases were given anti-schistosomal drugs (oxamniquine
Deelder, Andre M. +5 more
core +1 more source
Rate of action of schistosomicides in mice infected with Schistosoma mansoni
Revista da Sociedade Brasileira de Medicina Tropical, 1989 Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel.
Naftale Katz +4 more
doaj +3 more sources