Results 1 to 10 of about 11,863 (256)

Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines [PDF]

Beilstein Journal of Organic Chemistry, 2009
A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted
Reinhold Zimmer, Elmar Schmidt, Michal Andrä, Marcel-Antoine Duhs, Igor Linder, Hans-Ulrich Reissig   +5 more
doaj   +2 more sources

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo. [PDF]

PLoS ONE, 2016
Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis of several proinflammatory diseases including number of cancers and inflammatory bowel diseases.
Anilkumar C Nirvanappa, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Hanumappa Ananda, Alexey Yu Sukhorukov, Muthu K Shanmugam, Mahalingam S Sundaram, Siddaiah Chandra Nayaka, Kesturu S Girish, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Gautam Sethi, Basappa, Kanchugarakoppal S Rangappa   +14 more
doaj   +2 more sources

Gold(I)-Catalyzed Synthesis of 4H‑Benzo[d][1,3]oxazines and Biological Evaluation of Activity in Breast Cancer Cells

ACS Omega, 2022
The first gold(I)-catalyzed cycloisomerization procedure applied to the synthesis of substituted 4H-benzo[d][1,3]oxazines has been developed starting from N-(2-alkynyl)aryl benzamides.
Luis A. Segura-Quezada, Karina R. Torres-Carbajal, Narendra Mali, Dipak B. Patil, Mauricio Luna-Chagolla, Rafael Ortiz-Alvarado, Melissa Tapia-Juárez, Ixamail Fraire-Soto, Jorge Gustavo Araujo-Huitrado, Angelica Judith Granados-López, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes-Estrada, Yamilé López-Hernández, Jesús Adrián López, Luis Chacón-García, César R. Solorio-Alvarado   +15 more
doaj   +2 more sources

Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines

Beilstein Journal of Organic Chemistry, 2014
Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization.
Alexander F. Khlebnikov, Mikhail S. Novikov, Yelizaveta G. Gorbunova, Ekaterina E. Galenko, Kirill I. Mikhailov, Viktoriia V. Pakalnis, Margarita S. Avdontceva   +6 more
doaj   +2 more sources

Azirinium ylides from α-diazoketones and 2H-azirines on the route to 2H-1,4-oxazines: three-membered ring opening vs 1,5-cyclization

Beilstein Journal of Organic Chemistry, 2015
Strained azirinium ylides derived from 2H-azirines and α-diazoketones under Rh(II)-catalysis can undergo either irreversible ring opening across the N–C2 bond to 2-azabuta-1,3-dienes that further cyclize to 2H-1,4-oxazines or reversibly undergo a 1,5 ...
Nikolai V. Rostovskii, Mikhail S. Novikov, Alexander F. Khlebnikov, Galina L. Starova, Margarita S. Avdontseva   +4 more
doaj   +2 more sources

Oxazines: A New Class of Second-Order Nonlinear Optical Switches

Journal of the American Chemical Society, 2016
A combined experimental-theoretical investigation has revealed that oxazine-based compounds are multiaddressable, multistate, and multifunctional molecular switches exhibiting contrasts of both linear and second-order nonlinear optical properties. The switching properties are particularly large when the substituent is a donor group.
Beaujean, Pierre, Bondu, Flavie, Plaquet, Aurélie, Garcia-Amoros, Jaume, Cusido, Janet, Raymo, Françiso M., Castet, Frédéric, Rodriguez, Vincent, Champagne, Benoît   +8 more
openaire   +3 more sources

Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial inhibitors [PDF]

Scientific Reports
The current study offers a metal-free, direct, and successful synthesis technique for a new series of quinolinone and benzo[d][1,3]oxazine, along with an assessment of their biological activities.
Doaa A. Elsayed, Mohamed E. Abdu, Mohammed A. Marzouk, Elsayed M. Mahmoud, Walaa H. El-Shwiniy, Andrew M. Spring, Wesam S. Shehab   +6 more
doaj   +2 more sources

Self-Organization in Dilute Aqueous Solutions of Thermoresponsive Star-Shaped Six-Arm Poly-2-Alkyl-2-Oxazines and Poly-2-Alkyl-2-Oxazolines

Polymers, 2021
The behavior of star-shaped six-arm poly-2-alkyl-2-oxazines and poly-2-alkyl-2-oxazolines in aqueous solutions on heating was studied by light scattering, turbidimetry and microcalorimetry.
T. Kirila, A. Smirnova, V. Aseyev, A. Tenkovtsev, H. Tenhu, A. Filippov   +5 more
semanticscholar   +1 more source

Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells

Biomedicines, 2023
Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +10 more
doaj   +1 more source

Cycloaddition of 4-Acyl-1H-pyrrole-2,3-diones Fused at [e]-Side and Cyanamides: Divergent Approach to 4H-1,3-Oxazines

Molecules, 2022
4-Acyl-1H-pyrrole-2,3-diones fused at [e]-side with a heterocyclic moiety are suitable platforms for the development of a hetero-Diels–Alder-reaction-based, diversity-oriented approaches to series of skeletally diverse heterocycles.
Ekaterina E. Khramtsova, Aleksandr D. Krainov, Maksim V. Dmitriev, Andrey N. Maslivets   +3 more
doaj   +1 more source