Results 1 to 10 of about 11,541 (257)

Fast and Stable Photochromic Oxazines. [PDF]

The Journal of Organic Chemistry, 2005
We have designed and synthesized two photochromic compounds incorporating fused indoline and benzooxazine fragments. Variable-temperature 1H NMR spectroscopy demonstrates that their central [1,3]oxazine ring opens thermally with free energy barriers ranging from 14 to 19 kcal mol(-1).
Tomasulo M, SORTINO, Salvatore, White AJP, Raymo FM   +3 more
openaire   +5 more sources

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo. [PDF]

PLoS ONE, 2016
Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis of several proinflammatory diseases including number of cancers and inflammatory bowel diseases.
Anilkumar C Nirvanappa, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Hanumappa Ananda, Alexey Yu Sukhorukov, Muthu K Shanmugam, Mahalingam S Sundaram, Siddaiah Chandra Nayaka, Kesturu S Girish, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Gautam Sethi, Basappa, Kanchugarakoppal S Rangappa   +14 more
doaj   +2 more sources

Gold(I)-Catalyzed Synthesis of 4H‑Benzo[d][1,3]oxazines and Biological Evaluation of Activity in Breast Cancer Cells

ACS Omega, 2022
The first gold(I)-catalyzed cycloisomerization procedure applied to the synthesis of substituted 4H-benzo[d][1,3]oxazines has been developed starting from N-(2-alkynyl)aryl benzamides.
Luis A. Segura-Quezada, Karina R. Torres-Carbajal, Narendra Mali, Dipak B. Patil, Mauricio Luna-Chagolla, Rafael Ortiz-Alvarado, Melissa Tapia-Juárez, Ixamail Fraire-Soto, Jorge Gustavo Araujo-Huitrado, Angelica Judith Granados-López, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes-Estrada, Yamilé López-Hernández, Jesús Adrián López, Luis Chacón-García, César R. Solorio-Alvarado   +15 more
doaj   +2 more sources

Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells [PDF]

Biomedicines, 2023
Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +10 more
doaj   +2 more sources

Discovery of C-3 Tethered 2-oxo-benzo[1,4]oxazines as Potent Antioxidants: Bio-Inspired Based Design, Synthesis, Biological Evaluation, Cytotoxic, and in Silico Molecular Docking Studies

Frontiers in Chemistry, 2018
The discovery of C-3 tethered 2-oxo-benzo[1,4]oxazines as potent antioxidants is disclosed. All the analogs 20a-20ab have been synthesized via “on water” ultrasound-assisted irradiation conditions in excellent yields (upto 98%).
Vashundhra Sharma, Pradeep K. Jaiswal, Mukesh Saran, Dharmendra Kumar Yadav, Saloni, Manas Mathur, Ajit K. Swami, Sanjeev Misra, Mi-hyun Kim, Sandeep Chaudhary   +9 more
doaj   +2 more sources

One-pot synthesis of naphtho[1,2-e][1,3]oxazines in the presence of FNAOSiPAMP*/CuII as an almond shell based nanocatalyst [PDF]

Scientific Reports, 2022
In the present research work, a novel catalyst based on natural material, namely, Fe3O4@nano-almondshell@OSi(CH2)3/NHCH2pyridine/CuII abbreviated (FNAOSiPAMP/CuII) was designed and prepared.
Mina Keihanfar, Bi Bi Fatemeh Mirjalili
doaj   +2 more sources

Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines

Beilstein Journal of Organic Chemistry, 2014
Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization.
Alexander F. Khlebnikov, Mikhail S. Novikov, Yelizaveta G. Gorbunova, Ekaterina E. Galenko, Kirill I. Mikhailov, Viktoriia V. Pakalnis, Margarita S. Avdontceva   +6 more
doaj   +2 more sources

Azirinium ylides from α-diazoketones and 2H-azirines on the route to 2H-1,4-oxazines: three-membered ring opening vs 1,5-cyclization

Beilstein Journal of Organic Chemistry, 2015
Strained azirinium ylides derived from 2H-azirines and α-diazoketones under Rh(II)-catalysis can undergo either irreversible ring opening across the N–C2 bond to 2-azabuta-1,3-dienes that further cyclize to 2H-1,4-oxazines or reversibly undergo a 1,5 ...
Nikolai V. Rostovskii, Mikhail S. Novikov, Alexander F. Khlebnikov, Galina L. Starova, Margarita S. Avdontseva   +4 more
doaj   +2 more sources

Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial inhibitors [PDF]

Scientific Reports
The current study offers a metal-free, direct, and successful synthesis technique for a new series of quinolinone and benzo[d][1,3]oxazine, along with an assessment of their biological activities.
Doaa A. Elsayed, Mohamed E. Abdu, Mohammed A. Marzouk, Elsayed M. Mahmoud, Walaa H. El-Shwiniy, Andrew M. Spring, Wesam S. Shehab   +6 more
doaj   +2 more sources

7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis

Journal of Medicinal Chemistry, 2017
Within a backup program for the clinical investigational agent pretomanid (PA-824), scaffold hopping from delamanid inspired the discovery of a novel class of potent antitubercular agents that unexpectedly possessed notable utility against the ...
A. M. Thompson, Patrick D. O’Connor, A. J. Marshall, V. Yardley, L. Maes, Suman Gupta, D. Launay, S. Braillard, E. Chatelain, S. Franzblau, Baojie Wan, Yuehong Wang, Zhenkun Ma, Christopher B. Cooper, W. Denny   +14 more
semanticscholar   +2 more sources