Evaluation of the Antioxidant Activity of Cis/Trans-N-Phenyl-1,4,4a,5,8,8a-Hexahydro-3,1-Benzoxazin-2-Imines [PDF]
Antioxidants, 2019 The growing interest in the chemistry of unsaturated ring-fused 1,3-heterocycles, in this particular case 1,3-oxazines, arise in part from their versatile pharmacological applications.
Guadalupe Firpo +10 more
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Iodination of carbohydrate-derived 1,2-oxazines to enantiopure 5-iodo-3,6-dihydro-2H-1,2-oxazines and subsequent palladium-catalyzed cross-coupling reactions [PDF]
Beilstein Journal of Organic Chemistry, 2016 Iodination of carbohydrate-derived 3,6-dihydro-2H-1,2-oxazines of type 3 using iodine and pyridine in DMF furnished 5-iodo-substituted 1,2-oxazine derivatives 4 with high efficacy. The alkenyl iodide moiety of 1,2-oxazine derivatives syn-4 and anti-4 was
Michal Medvecký +4 more
doaj +3 more sources
Fast and Stable Photochromic Oxazines. [PDF]
The Journal of Organic Chemistry, 2006 We have designed and synthesized two photochromic compounds incorporating fused indoline and benzooxazine fragments. Variable-temperature 1H NMR spectroscopy demonstrates that their central [1,3]oxazine ring opens thermally with free energy barriers ranging from 14 to 19 kcal mol(-1).
Massimiliano Tomasulo +3 more
openalex +5 more sources
Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF-κB in Human Breast Cancer Cells. [PDF]
Biomedicines, 2023 Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Ravish A +10 more
europepmc +2 more sources
Cycloaddition of 4-Acyl-1H-pyrrole-2,3-diones Fused at [e]-Side and Cyanamides: Divergent Approach to 4H-1,3-Oxazines. [PDF]
Molecules, 2022 4-Acyl-1H-pyrrole-2,3-diones fused at [e]-side with a heterocyclic moiety are suitable platforms for the development of a hetero-Diels–Alder-reaction-based, diversity-oriented approaches to series of skeletally diverse heterocycles.
Khramtsova EE +3 more
europepmc +2 more sources
Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo [PDF]
PLoS ONE, 2016 Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis of several proinflammatory diseases including number of cancers and inflammatory bowel diseases.
Basappa +2 more
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One-pot synthesis of naphtho[1,2-e][1,3]oxazines in the presence of FNAOSiPAMP*/CuII as an almond shell based nanocatalyst. [PDF]
Sci Rep, 2022 In the present research work, a novel catalyst based on natural material, namely, Fe3O4@nano-almondshell@OSi(CH2)3/NHCH2pyridine/CuII abbreviated (FNAOSiPAMP/CuII) was designed and prepared.
Keihanfar M, Mirjalili BBF.
europepmc +2 more sources
Frontiers in Chemistry, 2018 The discovery of C-3 tethered 2-oxo-benzo[1,4]oxazines as potent antioxidants is disclosed. All the analogs 20a-20ab have been synthesized via “on water” ultrasound-assisted irradiation conditions in excellent yields (upto 98%).
Mukesh Saran +2 more
exaly +3 more sources
Metal-catalyzed Cyclizations to Pyran and Oxazine Derivatives [PDF]
Synthesis, 2016 NOTICE: This is the peer reviewed version of the following article: Varela, J. A., Saá, C. (2016). Metal-catalyzed Cyclizations to Pyran and Oxazine Derivatives. Synthesis, 48, 20, 3470-3478. [doi: 10.1055/s-0035-1562466].
Saá Rodríguez, Carlos +1 more
core +4 more sources
Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial inhibitors. [PDF]
Sci RepThe current study offers a metal-free, direct, and successful synthesis technique for a new series of quinolinone and benzo[d][1,3]oxazine, along with an assessment of their biological activities.
Elsayed DA +6 more
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