Results 61 to 70 of about 11,863 (256)

Copper Catalyzed Inverse Electron Demand [4+2] Cycloaddition for the Synthesis of Oxazines [PDF]

open access: gold, 2022
Weiguang Yang   +7 more
openalex   +1 more source

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non‐Human Primates

open access: yesPROTEOMICS, Volume 26, Issue 1, Page 100-107, January 2026.
ABSTRACT The β‐secretase BACE1 (β‐site amyloid precursor (APP) cleaving enzyme 1) is a major drug target for Alzheimer's disease (AD), as it catalyzes the first step in amyloid β (Aβ) generation, but has additional substrates and functions, in particular in the brain.
Sarah K. Tschirner   +7 more
wiley   +1 more source

Synthesis of Substituted Pyrido-oxazine through Tandem SN2 and SNAr Reaction

open access: yesSynOpen, 2018
Pyrido-oxazine derivatives have been synthesized by employing tandem SN2 and SNAr reaction between 2,4,6-tribromo-3-(2-bromoethoxy)pyridine or 2,4,6-tribromo-3-(3-bromopropoxy)pyridine and a variety of primary amines. Moderate to good regioselectivity in
Mosim Amin Pathan, Faiz Ahmed Khan
doaj   +1 more source

Catalytic Strategies for Amide‐Based Michael Additions: Advances and Perspectives

open access: yesJournal of Chemistry, Volume 2026, Issue 1, 2026.
The Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β‐unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α,β‐unsaturated amides remain underutilized due to their strong resonance stabilization and low ...
Muhammad Naufal   +6 more
wiley   +1 more source

Transition Metal-Free Cascade Cyclization of Epoxy-Ynamides: To Go for 1,3-Oxazines or 1,4-Oxazines?

open access: yesOrganic Letters, 2016
An approach to both 1,3- and 1,4-oxazines is developed by the cascade cyclization of epoxy ynamides under transition metal-free conditions. Thus, while 1,3-oxazines are obtained in a regio- and stereoselective manner by using base, cyclization of epoxy ...
A. Siva Kumari, A. Siva Reddy, K. Swamy
semanticscholar   +1 more source

Characterisation of Volatile Compounds Associated With the Flavour of Flatbreads: Effect of Sorghum, Cassava and Whole or Dehulled Red and White Cowpea Flours

open access: yesLegume Science, Volume 7, Issue 4, December 2025.
ABSTRACT This study characterised the volatile compounds in flatbreads prepared from red non‐tannin sorghum flour, cassava starch, whole and dehulled red and white cowpea flours and composite flours (30% cowpea flour and varying combinations of cassava starch and sorghum flour).
Rita Dankwa   +5 more
wiley   +1 more source

Microwave-assisted one-pot efficient synthesis of functionalized 2-oxo-2-phenylethylidenes-linked 2-oxo-benzo[1,4]oxazines and 2-oxo-quino[1,4]oxalines: Synthetic Applications, Antioxidant activity, SAR and Cytotoxic Studies

open access: yesActa Chimica Slovenica, 2017
A microwave-assisted, environmentally benign green protocol for the synthesis of functionalized (Z)-3-(2-oxo-2-phenylethylidene)-3, 4-dihydro-2H-benzo[b][1,4]oxazin-2-ones 11a-n in excellent yields (upto 97%) and (Z)-3-(2-oxo-2-phenylethylidene)-3,4 ...
Vashundhra Sharma   +8 more
doaj   +1 more source

Synthesis and HPLC-ECD Study of Cytostatic Condensed O,N-Heterocycles Obtained from 3-Aminoflavanones

open access: yesBiomolecules, 2020
Racemic chiral O,N-heterocycles containing 2-arylchroman or 2-aryl-2H-chromene subunit condensed with morpholine, thiazole, or pyrrole moieties at the C-3-C-4 bond were synthesized with various substitution patterns of the aryl group by the cyclization ...
Ádám Szappanos   +10 more
doaj   +1 more source

Development of High‐Performance Ablative Composites: Synergistic Effects of Alumina Particles and Silica Fabric in the Polybenzoxazine Matrix

open access: yesPolymer Composites, Volume 46, Issue 16, Page 14849-14861, 10 November 2025.
The illustration depicts the improvement in the mechanical and ablative properties of polybenzoxazine composites according to their alumina particle content. ABSTRACT The aerospace industry is seeking a replacement of toxic phenolics to use in ablative materials. One of the most promising candidates is polybenzoxazine materials because of their extreme
İ. Egemen Küçük   +2 more
wiley   +1 more source

Applications of QSPR and Machine Learning in Molecular Photonics

open access: yesAdvanced Optical Materials, Volume 13, Issue 33, November 25, 2025.
Quantitative structureproperty relationships (QSPR) and machine learning (ML) are transforming photochemistry by enabling pre‐synthetic screening of photoactive molecules. This review outlines advances in data‐driven discovery of optical materials and functional dyes, identifies effective descriptors and models for photophysical processes, and provides
Andrey A. Buglak   +2 more
wiley   +1 more source

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