Results 121 to 130 of about 24,125 (306)

On the Synthesis of [1,3]Azaphospholo[4,5‐f]quino(xa)lines and 2,3‐Dihydro‐[1,3]azaphospholo[4,5‐f]quino(xa)line 1‐oxides

European Journal of Organic Chemistry, Volume 28, Issue 17, May 21, 2025.
Syntheses of quinoline and quinoxaline derivatives fused with phosphacycles were developed from commercially available quinolin‐6‐amine and quinoxalin‐6‐amine. Abstract Despite their potential in areas such as medicinal chemistry and organic materials, scaffolds in which quinoline and quinoxaline are fused to phosphacycles such as 1,3‐oxaphosphole, 1,3‐
Mohamed Ali Dridi, Mohamed Hasyeoui, Frédéric Lassagne, William Erb, Charline Piroud, Thomas Robert, Stéphane Bach, Ali Samarat, Soufiane Touil, Florence Mongin   +9 more
wiley   +1 more source

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality [PDF]

, 2013
A significant challenge in chemistry is to rationally reproduce the functional potency of a protein in a small molecule, which is cheaper to manufacture, non-immunogenic, and also both stable and bioavailable.
A Ghassemian, A Jacob, A Sonesson, AS Kirshenbaum, BL Wu, BN Bullock, CC Scully, D Seebach, DP Fairlie, EB Grant, F Denonne, F Denonne, G Bajic, G Ruiz-Gomez, H Takematsu, H Yin, H-C Wilken, J Kildsgaard, J Lim, J Venkatraman, JA Ember, JDA Tyndall, JM Scholtz, JZ Sun, KD Stigers, L Dreier, LM Proctor, M Pasupuleti, MN Munkonda, N Mizutani, NP Gerard, P Hutamekalin, P-J Haas, PF Zipfel, R Huber, RS Ames, SL Masters, TE Hugli, TE Hugli, TH Chao, VA Bokisch, WF DeGrado, Y Fukuoka, Y Mamane, Z Tang   +44 more
core   +1 more source

Identification and synthesis of metabolites of the new antiglaucoma drug

Research Results in Pharmacology
Introduction: The determination of biotransformation products is an essential part of the preclinical trial of original medicines. These studies have not been conducted before for the new drug 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide.
Alexander L. Khokhlov, Ilya I. Yaichkov, Anton А. Shetnev, Sergey A. Ivanovsky, Mikhail K. Korsakov, Mikhail A. Alexeev, Olga A. Gasilina, Nikita N. Volkhin, Sergey S. Petukhov   +8 more
doaj   +1 more source

(E)-4-(3-Phenylisoxazol-5-yl)but-3-en-2-one

Molbank, 2019
(E)-4-(3-Phenylisoxazol-5-yl)but-3-en-2-one was synthesized via the oxidative ring opening reaction of 2-(5-methylfuran-2-yl)-1-phenylethanone oxime, followed by the iodine mediated isomerization.
Nattawut Sawengngen, Alexandra A. Kolodina, Olga V. Serdyuk   +2 more
doaj   +1 more source

Synthetic utility and reactivity of N-alkynylazoles [PDF]

, 2015
textThe chemistry of N-alkynylazoles is a newly emerging area of chemistry with particular interest in heterocycle synthesis. Synthetic preparations of this class of molecule have shown an increasing presence in literature, however, the synthetic ...
Gilbreath, Bradford Lynd
core  

A cooperative Pd-Cu system for direct C-H bond arylation [PDF]

, 2014
The authors are grateful to the Royal Society (University Research Fellowship to CSJC) for financial support.A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed.
Cazin, Catherine S. J., Lazreg, Faima, Lesieur, Mathieu   +2 more
core   +1 more source

Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin. [PDF]

, 2015
Conglobatin is an unusual C2-symmetrical macrodiolide from the bacterium Streptomyces conglobatus with promising antitumor activity. Insights into the genes and enzymes that govern both the assembly-line production of the conglobatin polyketide and its ...
Dias, Luiz Carlos, Leadlay, Peter F, Murphy, Annabel C, Prediger, Patricia, Samborskyy, Markiyan, Zhou, Yongjun   +5 more
core   +2 more sources

Oxazole Dyes With Potential For Photoluminescence Bioprobes: A Two-Photon Absorption Study

, 2018
In this work, six π-conjugated oxazole compounds dissolved in dichloromethane were characterized with linear and nonlinear optical measurements. Z-scan with femtosecond laser pulses was employed to determine the two-photon absorption (TPA) spectra. Other
L. Abegão, R. D. Fonseca, Tárcius N. Ramos, F. Mahuteau-Betzer, S. Piguel, R. J. Joatan, C. Mendonca, S. Canuto, D. L. Silva, L. Boni   +9 more
semanticscholar   +1 more source

Sir John Cornforth AC CBE FRS: his synthetic work [PDF]

, 2015
Sir John Cornforth’s work on the synthesis of cholesterol and penicillamine, on the chemistry of oxazoles, the stereochemistry of the synthesis of alkenes, the synthesis of abscisic acid and of dibenzophospholes as mimics of enzyme action, is ...
Abraham E.P., Abraham E.P., Abraham E.P., Callow R.K., Cardwell H.M.E., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., James R. Hanson, Rupert Purchase   +15 more
core   +1 more source

Crystal structure and Hirshfeld surface analysis of 5-[(5-nitro-1H-indazol-1-yl)methyl]-3-phenyl-4,5-dihydroisoxazole

Acta Crystallographica Section E: Crystallographic Communications, 2019
In the title compound, C17H14N4O3, the indazole unit is planar to within 0.0171 (10) Å and makes dihedral angles of 6.50 (6) and 6.79 (4)°, respectively, with the nitro and pendant phenyl groups.
Mohammed Boulhaoua, Sevgi Kansiz, Mohamed El Hafi, Sanae Lahmidi, Necmi Dege, Mohammed Benchidmi, Joel T. Mague   +6 more
doaj   +1 more source