The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions. [PDF]
, 2014 A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor ...
Battilocchio, Claudio +6 more
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Total synthesis of the azolemycins [PDF]
, 2015 The first total syntheses of newly isolated polyazole natural products azolemycins A–D, along with the synthesis of the tetra-oxazole non-natural analogue, are ...
Anderson, Zoe J., Fox, David J.
core
Oxazoline Promoted Rh-Catalyzed C-H Amidation of Benzene Derivatives with Sulfonamides and Trifluoroacetamide. A Comparative Study. [PDF]
, 2016 A Rh-catalyzed ortho-amidation of 2-aryloxazolines offers an efficient and direct route to a range of sulfonamides. The scope of the reaction is very broad with respect to sulfonamide substrate, but the position and electronic nature of the substituents ...
Harrity, J.P. +3 more
core +3 more sources
Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily. [PDF]
, 2017 Insight regarding how diverse enzymatic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and for the exploitation of enzymes for biotechnology.
Akiva, Eyal +3 more
core +1 more source
Preparation of (S)-tert-ButylPHOX (Oxazole, 4-(1,1-dimethylethyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro- (4S)-) [PDF]
, 2009 [No ...
Krout, Michael R. +3 more
core +1 more source
Identification and synthesis of metabolites of the new antiglaucoma drug
Research Results in PharmacologyIntroduction: The determination of biotransformation products is an essential part of the preclinical trial of original medicines. These studies have not been conducted before for the new drug 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide.
Alexander L. Khokhlov +8 more
doaj +1 more source
Total Synthesis of Bacterial 5-(3-Indolyl)oxazole Alkaloids: Pimprinols A–C
SynOpen, 2019 Pimprinols A, B, and C are bacterial 5-(3-indolyl)oxazole alkaloids that have been isolated from Streptomyces sp. Lv3–13. In this paper, we report a new synthesis of pimprinol A and the first total synthesis of pimprinol B and pimprinol C.
Tímea Szabó +4 more
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2019 In the title compound, C17H14N4O3, the indazole unit is planar to within 0.0171 (10) Å and makes dihedral angles of 6.50 (6) and 6.79 (4)°, respectively, with the nitro and pendant phenyl groups.
Mohammed Boulhaoua +6 more
doaj +1 more source
The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators. [PDF]
, 2019 Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated ...
Brown, Brandon M +6 more
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Beilstein Journal of Organic ChemistryThe N,O-acetal derived from diethyl mesoxalate (DEMO) undergoes elimination of acetic acid upon treatment with a base, leading to the formation of N-acylimine in situ.
Kento Iwai +5 more
doaj +1 more source