Results 131 to 140 of about 6,197 (174)

Oxazolidinones: a novel class of antibiotics

Cellular and Molecular Life Sciences (CMLS), 1999
Oxazolidinones are a novel class of synthetic antimicrobial agents which have now entered phase III clinical trials. The most promising feature of these compounds is their oral activity against multidrug-resistant Gram-positive bacteria which have created tremendous therapeutic problems in recent years.
M, Müller, K L, Schimz
openaire   +2 more sources

Oxazolidinones: New antibacterial agents

Trends in Microbiology, 1997
The oxazolidinones are a new chemical class of synthetic antibacterial agents that are active orally or intravenously against multidrug-resistant Gram-positive bacteria. Their unique mechanism of action and activity against bacteria that pose therapeutic problems in hospital and community treatments make them promising candidates for antimicrobial ...
C W, Ford, J C, Hamel, D, Stapert, J K, Moerman, D K, Hutchinson, M R, Barbachyn, G E, Zurenko   +6 more
openaire   +2 more sources

Tedizolid: A new oxazolidinone antimicrobial

American Journal of Health-System Pharmacy, 2014
The mechanism of action, pharmacokinetics, pharmacodynamics, and clinical efficacy and safety of an investigational second-generation oxazolidinone are reviewed.Tedizolid is a protein synthesis inhibitor in clinical development for the treatment of gram-positive infections.
Kisgen, Jamie J., Mansour, Hanine, Unger, Nathan R., Childs, Lindsay M   +3 more
openaire   +3 more sources

Oxazolidinones: a new class of antibacterials

Current Opinion in Pharmacology, 2001
The oxazolidinones represent the first truly new class of antibacterial agents to reach the marketplace in several decades. They have a unique mechanism of action involving inhibition of the initiation step of protein synthesis and are not cross-resistant to other classes of antibiotics. The first marketed member of that class, linezolid (Zyvox), shows
G E, Zurenko, J K, Gibson, D L, Shinabarger, P A, Aristoff, C W, Ford, W G, Tarpley   +5 more
openaire   +2 more sources

Linezolid: an oxazolidinone antimicrobial agent

Clinical Therapeutics, 2001
Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium ...
H B, Fung, H L, Kirschenbaum, B O, Ojofeitimi   +2 more
openaire   +2 more sources

The oxazolidinones: past, present, and future

Annals of the New York Academy of Sciences, 2011
The success of linezolid stimulated significant efforts to discover new agents in the oxazolidinone class. Over a dozen oxazolidinones have reached the clinic, but many were discontinued due to lack of differentiated potency, inadequate pharmacokinetics, and safety risks that included myelosuppression.
Karen Joy, Shaw, Michael R, Barbachyn
openaire   +2 more sources

Antimycobacterial Activities of Oxazolidinones: A Review

Infectious Disorders - Drug Targets, 2006
Oxazolidinones are a new class of totally synthetic antibacterial agents with wide spectrum of activity against a variety of clinically significant susceptible and resistant bacteria. These compounds have been shown to inhibit translation at the initiation phase of protein synthesis.
R, Sood, T, Bhadauriya, M, Rao, R, Gautam, S, Malhotra, T K, Barman, D J, Upadhyay, A, Rattan   +7 more
openaire   +2 more sources

Linezolid - a review of the first oxazolidinone

Expert Opinion on Pharmacotherapy, 2001
Linezolid is the first of a truly new class of antibiotics, the oxazolidinones. It acts as an inhibitor of bacterial protein synthesis by blocking the formation of the 70S ribosomal initiation complex. Its activity is bacteriostatic against some species (e.g., enterococci) and bactericidal against others (e.g., pneumococci).
openaire   +2 more sources

Linezolid: An oxazolidinone antimicrobial agent

American Journal of Health-System Pharmacy, 2002
The pharmacology, antimicrobial activity, pharmacokinetics, clinical efficacy, and adverse effects of linezolid are reviewed. Linezolid, the only oxazolidinone antimicrobial approved for use in the United States, has significant activity against gram-positive bacteria, including penicillin-, cephalosporin-, and vancomycin-resistant species.
openaire   +2 more sources

Oxazolidinones

2006
  +5 more sources